Matches in SemOpenAlex for { <https://semopenalex.org/work/W1819581615> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W1819581615 endingPage "7" @default.
- W1819581615 startingPage "5634" @default.
- W1819581615 abstract "The DNA-damaging effects of 2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone (AZQ) in Chinese hamster ovary cells were investigated. As determined by alkaline elution, DNA strand breaks were observed in cells treated with 50 microM AZQ for 2 hr. The single-strand break frequency was 31.3 +/- 5.3 (S.D.) rad equivalents. Strand breaks could also be detected at lower drug concentration if proteinase K treatment was included before DNA elution. In comparison, DNA cross-links were apparent in cells treated with as low as 6.25 microM AZQ. The cross-linking frequencies were 39.7, 124.3, 230.3, and 625.1 rad-equivalents for 6.25, 12.5, 25, and 50 microM AZQ, respectively. Both DNA-DNA and DNA-protein cross-links in AZQ-treated cells were revealed by the proteinase K assay. The DNA strand breaks induced by AZQ were rapidly rejoined within 1 hr after drug removal. DNA interstrand cross-links increased within the first 6 hr of postincubation and then slightly decreased by 12 hr, and most of the cross-links disappeared after cells were allowed to recover for 24 hr. DNA-protein cross-links were immediately formed during the drug treatment period and were gradually decreased after drug removal." @default.
- W1819581615 created "2016-06-24" @default.
- W1819581615 creator A5002666791 @default.
- W1819581615 creator A5030273536 @default.
- W1819581615 creator A5073876235 @default.
- W1819581615 date "1984-12-01" @default.
- W1819581615 modified "2023-09-23" @default.
- W1819581615 title "Induction of DNA strand breaks and cross-links by 2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone in Chinese hamster ovary cells." @default.
- W1819581615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6498824" @default.
- W1819581615 hasPublicationYear "1984" @default.
- W1819581615 type Work @default.
- W1819581615 sameAs 1819581615 @default.
- W1819581615 citedByCount "11" @default.
- W1819581615 crossrefType "journal-article" @default.
- W1819581615 hasAuthorship W1819581615A5002666791 @default.
- W1819581615 hasAuthorship W1819581615A5030273536 @default.
- W1819581615 hasAuthorship W1819581615A5073876235 @default.
- W1819581615 hasConcept C153911025 @default.
- W1819581615 hasConcept C175656101 @default.
- W1819581615 hasConcept C185581394 @default.
- W1819581615 hasConcept C185592680 @default.
- W1819581615 hasConcept C54355233 @default.
- W1819581615 hasConcept C552990157 @default.
- W1819581615 hasConcept C55493867 @default.
- W1819581615 hasConcept C81885089 @default.
- W1819581615 hasConcept C86803240 @default.
- W1819581615 hasConceptScore W1819581615C153911025 @default.
- W1819581615 hasConceptScore W1819581615C175656101 @default.
- W1819581615 hasConceptScore W1819581615C185581394 @default.
- W1819581615 hasConceptScore W1819581615C185592680 @default.
- W1819581615 hasConceptScore W1819581615C54355233 @default.
- W1819581615 hasConceptScore W1819581615C552990157 @default.
- W1819581615 hasConceptScore W1819581615C55493867 @default.
- W1819581615 hasConceptScore W1819581615C81885089 @default.
- W1819581615 hasConceptScore W1819581615C86803240 @default.
- W1819581615 hasIssue "12 Pt 1" @default.
- W1819581615 hasLocation W18195816151 @default.
- W1819581615 hasOpenAccess W1819581615 @default.
- W1819581615 hasPrimaryLocation W18195816151 @default.
- W1819581615 hasRelatedWork W1507865690 @default.
- W1819581615 hasRelatedWork W1551148190 @default.
- W1819581615 hasRelatedWork W1819581615 @default.
- W1819581615 hasRelatedWork W1858358649 @default.
- W1819581615 hasRelatedWork W2038796800 @default.
- W1819581615 hasRelatedWork W2047512715 @default.
- W1819581615 hasRelatedWork W2085119499 @default.
- W1819581615 hasRelatedWork W2106740562 @default.
- W1819581615 hasRelatedWork W2317009758 @default.
- W1819581615 hasRelatedWork W4249613248 @default.
- W1819581615 hasVolume "44" @default.
- W1819581615 isParatext "false" @default.
- W1819581615 isRetracted "false" @default.
- W1819581615 magId "1819581615" @default.
- W1819581615 workType "article" @default.