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• W1819750950 endingPage "540" @default.
• W1819750950 startingPage "527" @default.
• W1819750950 abstract "The 5-HT3 receptor is a neurotransmitter-gated ion channel. It is a member of the Cys-loop family of receptors, which also includes nicotinic acetylcholine, glycine and GABAA receptors. Each member of the family consists of an arrangement of five subunits surrounding a central ion-conducting pore. The 5-HT3 receptor binding site is composed of six loops from two adjacent subunits, and the critical ligand binding residues within these loops are well documented. There are a range of 5-HT3 receptor agonists and competitive antagonists, but it is the antagonists that dominate their clinical use. Studies have proposed a range of disease symptoms that might be amenable to 5-HT3 receptor selective compounds; however, so far only the treatment of emesis and irritable bowel syndrome have been fully realised. In this review, the authors look at the structure, function and distribution of 5-HT3 receptors and how this may influence their role in disease. The authors also describe the existing clinical applications of 5-HT3 antagonists and the future potential of these drugs." @default.
• W1819750950 created "2016-06-24" @default.
• W1819750950 creator A5047202581 @default.
• W1819750950 creator A5051760158 @default.
• W1819750950 date "2007-03-20" @default.
• W1819750950 modified "2023-10-18" @default.
• W1819750950 title "The 5-HT₃receptor as a therapeutic target" @default.
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