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• W181979430 abstract "This chapter discusses the systemic activation of macrophages by liposomes containing synthetic immunomodulators for the treatment of metastatic disease. Macrophages are an active component of the immune response that are responsible for identifying and phagocytosing micro-organisms, foreign material, and cellular debris, as well as for the recognition of self versus altered self, e.g., neoplastic cells. If macrophages could be activated to their tumoricidal state, they would make an ideal modality for the treatment of metastatic disease that is resistant to other forms of therapy. Because macrophages are phagocytic, the problem of rapid clearance of systemically administered cytokines and other immunomodulators can be overcome by encapsulating the activating agents into muti-lamellar vesicles (MLV) or liposomes composed of phospholipids. Macrophages can be activated to become tumoricidal by two major pathways in vivo . The first is by interaction with microorganisms or their products, such as bacterial cell wall components or endotoxins, and second by interaction with various cytokines or macrophage-activating factors, such as interferon-γ. However, systemic administration of cytokines showed a similar deficiency in the ability to activate tumoricidal activity of macrophages. This chapter explains about the in vitro activation of human monocytes by liposomes containing N-acetyl muramyl- L -alanyl- D -isoglutamyl- L -alanyl-2-(l', 2' dipalmitoyl)-sn-glycero-3'-phosphorylethylamide (MTP-PE), and clinical trials with lipid bilayer of liposomes (L-MTP-PE)." @default.
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• W181979430 date "1998-01-01" @default.
• W181979430 modified "2023-09-25" @default.
• W181979430 title "Systemic activation of macrophages by liposomes containing synthetic immunomodulators for treatment of metastatic disease" @default.
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• W181979430 doi "https://doi.org/10.1016/b978-044482917-7/50005-3" @default.
• W181979430 hasPublicationYear "1998" @default.
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