FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1819974901> ?p ?o ?g. }

• W1819974901 endingPage "9" @default.
• W1819974901 startingPage "1261" @default.
• W1819974901 abstract "The hematopoietic system is controlled by growth factors (cytokines) which can influence cell survival, proliferation, differentiation and functional activation. The study of cytokine receptor expression by flow cytometry could allow us to differentiate between normal and tumoral cells.We analyzed the expression of the interleukin-3 (IL-3) receptor a chain (CD123) in 22 normal samples and in a wide panel of hematologic malignancies using flow cytometry. We found that CD123 was expressed in the myeloid progenitor subpopulation but in contrast, normal lymphoid progenitors lacked CD123. We analyzed the CD123 expression pattern in 64 patients with acute leukemia, 45 with acute myeloid leukemia (AML) and 19 with acute lymphocytic leukemia (ALL) (13 B-cell lineage ALL and 6 T-cell lineage ALL).All the AML cases except two patients with M7 and all the B-cell lineage ALL patients were CD123 positive. In contrast, all the T-cell lineage ALL cases tested were CD123 negative. We also studied the CD123 expression pattern in 122 patients with a B-cell chronic lymphoproliferative disease (B-CLPD). CD123 was positive in three situations: 1) typical cases of hairy cell leukemia showed a specific, strong CD123 expression, 2) a subgroup of atypical chronic lymphocytic leukemia with a marked CD11c expression was also CD123 positive, and finally 3) transformed B-CLPD showed the phenomenon of transition from CD123 negativity to CD123 positivity simultaneuosly with morphologic changes.In summary, our data show high expression of IL-3 receptor a chain in hematologic malignancies. Given the high frequency of CD123 reactivity in blast cells in contrast to in normal precursors, this antigen could be applied to the study of minimal residual disease in acute leukemia. CD123 is expressed with a characteristic pattern in cases of hairy cell leukemia." @default.
• W1819974901 created "2016-06-24" @default.
• W1819974901 creator A5006173909 @default.
• W1819974901 creator A5021939016 @default.
• W1819974901 creator A5025894116 @default.
• W1819974901 creator A5027357638 @default.
• W1819974901 creator A5033210828 @default.
• W1819974901 creator A5059808568 @default.
• W1819974901 creator A5062339161 @default.
• W1819974901 creator A5069257338 @default.
• W1819974901 date "2001-12-01" @default.
• W1819974901 modified "2023-10-06" @default.
• W1819974901 title "Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies." @default.
• W1819974901 cites W138285015 @default.
• W1819974901 cites W1526134400 @default.
• W1819974901 cites W1549389405 @default.
• W1819974901 cites W1554380543 @default.
• W1819974901 cites W1974607640 @default.
• W1819974901 cites W1975316089 @default.
• W1819974901 cites W1994886387 @default.
• W1819974901 cites W2057151285 @default.
• W1819974901 cites W2092210520 @default.
• W1819974901 cites W2095499709 @default.
• W1819974901 cites W2098717581 @default.
• W1819974901 cites W2098740686 @default.
• W1819974901 cites W2107202569 @default.
• W1819974901 cites W2131080367 @default.
• W1819974901 cites W2150113701 @default.
• W1819974901 cites W2159619345 @default.
• W1819974901 cites W2178809712 @default.
• W1819974901 cites W2307732956 @default.
• W1819974901 cites W2329654917 @default.
• W1819974901 cites W2337195173 @default.
• W1819974901 cites W2395914225 @default.
• W1819974901 cites W2414753427 @default.
• W1819974901 cites W2416896529 @default.
• W1819974901 cites W2417396324 @default.
• W1819974901 cites W2436272293 @default.
• W1819974901 cites W2437351780 @default.
• W1819974901 cites W2442004163 @default.
• W1819974901 cites W66436105 @default.
• W1819974901 cites W2409862460 @default.
• W1819974901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11726317" @default.
• W1819974901 hasPublicationYear "2001" @default.
• W1819974901 type Work @default.
• W1819974901 sameAs 1819974901 @default.
• W1819974901 citedByCount "112" @default.
• W1819974901 countsByYear W18199749012012 @default.
• W1819974901 countsByYear W18199749012014 @default.
• W1819974901 countsByYear W18199749012015 @default.
• W1819974901 countsByYear W18199749012016 @default.
• W1819974901 countsByYear W18199749012017 @default.
• W1819974901 countsByYear W18199749012018 @default.
• W1819974901 countsByYear W18199749012019 @default.
• W1819974901 countsByYear W18199749012020 @default.
• W1819974901 countsByYear W18199749012021 @default.
• W1819974901 countsByYear W18199749012022 @default.
• W1819974901 countsByYear W18199749012023 @default.
• W1819974901 crossrefType "journal-article" @default.
• W1819974901 hasAuthorship W1819974901A5006173909 @default.
• W1819974901 hasAuthorship W1819974901A5021939016 @default.
• W1819974901 hasAuthorship W1819974901A5025894116 @default.
• W1819974901 hasAuthorship W1819974901A5027357638 @default.
• W1819974901 hasAuthorship W1819974901A5033210828 @default.
• W1819974901 hasAuthorship W1819974901A5059808568 @default.
• W1819974901 hasAuthorship W1819974901A5062339161 @default.
• W1819974901 hasAuthorship W1819974901A5069257338 @default.
• W1819974901 hasConcept C109159458 @default.
• W1819974901 hasConcept C203014093 @default.
• W1819974901 hasConcept C2777938653 @default.
• W1819974901 hasConcept C2778461978 @default.
• W1819974901 hasConcept C2778729363 @default.
• W1819974901 hasConcept C2779282312 @default.
• W1819974901 hasConcept C28328180 @default.
• W1819974901 hasConcept C502942594 @default.
• W1819974901 hasConcept C553184892 @default.
• W1819974901 hasConcept C71924100 @default.
• W1819974901 hasConcept C83396363 @default.
• W1819974901 hasConcept C86803240 @default.
• W1819974901 hasConcept C95444343 @default.
• W1819974901 hasConceptScore W1819974901C109159458 @default.
• W1819974901 hasConceptScore W1819974901C203014093 @default.
• W1819974901 hasConceptScore W1819974901C2777938653 @default.
• W1819974901 hasConceptScore W1819974901C2778461978 @default.
• W1819974901 hasConceptScore W1819974901C2778729363 @default.
• W1819974901 hasConceptScore W1819974901C2779282312 @default.
• W1819974901 hasConceptScore W1819974901C28328180 @default.
• W1819974901 hasConceptScore W1819974901C502942594 @default.
• W1819974901 hasConceptScore W1819974901C553184892 @default.
• W1819974901 hasConceptScore W1819974901C71924100 @default.
• W1819974901 hasConceptScore W1819974901C83396363 @default.
• W1819974901 hasConceptScore W1819974901C86803240 @default.
• W1819974901 hasConceptScore W1819974901C95444343 @default.
• W1819974901 hasIssue "12" @default.
• W1819974901 hasLocation W18199749011 @default.
• W1819974901 hasOpenAccess W1819974901 @default.
• W1819974901 hasPrimaryLocation W18199749011 @default.
• W1819974901 hasRelatedWork W1981120003 @default.

• next