FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1820022443> ?p ?o ?g. }

• W1820022443 endingPage "131" @default.
• W1820022443 startingPage "124" @default.
• W1820022443 abstract "Pretransplant exposure to donor antigen is known to modulate recipient alloimmunity, and frequently results in sensitization. However, donor-specific transfusion (DST) can have a protolerant effect that is dependent on route, dose and coadministered immunosuppression. Rodent studies have shown in some strain combinations that portal venous (PV) DST alone can induce tolerance, and uncontrolled clinical use of PVDST has been reported. In order to determine if pretransplant PVDST has a clinically relevant salutary effect, we studied it and the influence of concomitant immunosuppression in rhesus monkeys undergoing renal allotransplantation. Animals received PVDST with unfractionated bone marrow and/or tacrolimus or sirolimus 1 week prior to transplantation. Graft survival was assessed without any posttransplant immunosuppression. PVDST alone or in combination with tacrolimus was ineffective. However, PVDST in combination with sirolimus significantly prolonged renal allograft survival to a mean of 24 days. Preoperative sirolimus alone had no effect, and peripheral DST with sirolimus prolonged graft survival in 2/4 animals, but resulted in accelerated rejection in 2/4 animals. These data demonstrate that PVDST in combination with sirolimus delays rejection in a modest but measurable way in a rigorous model. It may thus be a preferable method for donor antigen administration." @default.
• W1820022443 created "2016-06-24" @default.
• W1820022443 creator A5003099842 @default.
• W1820022443 creator A5027966692 @default.
• W1820022443 creator A5049239788 @default.
• W1820022443 creator A5052066520 @default.
• W1820022443 creator A5056389032 @default.
• W1820022443 creator A5066614686 @default.
• W1820022443 creator A5069136593 @default.
• W1820022443 creator A5073028134 @default.
• W1820022443 date "2009-01-01" @default.
• W1820022443 modified "2023-10-12" @default.
• W1820022443 title "Portal Venous Donor-Specific Transfusion in Conjunction with Sirolimus Prolongs Renal Allograft Survival in Nonhuman Primates" @default.
• W1820022443 cites W1555557841 @default.
• W1820022443 cites W1577618761 @default.
• W1820022443 cites W1581554632 @default.
• W1820022443 cites W1582941402 @default.
• W1820022443 cites W1764434452 @default.
• W1820022443 cites W1965994170 @default.
• W1820022443 cites W1971895216 @default.
• W1820022443 cites W1978313736 @default.
• W1820022443 cites W1985550983 @default.
• W1820022443 cites W2000000588 @default.
• W1820022443 cites W2001906428 @default.
• W1820022443 cites W2002196256 @default.
• W1820022443 cites W2008381728 @default.
• W1820022443 cites W2019291297 @default.
• W1820022443 cites W2020853616 @default.
• W1820022443 cites W2023244011 @default.
• W1820022443 cites W2039196444 @default.
• W1820022443 cites W2047894050 @default.
• W1820022443 cites W2054083392 @default.
• W1820022443 cites W2055692781 @default.
• W1820022443 cites W2062632117 @default.
• W1820022443 cites W2066671903 @default.
• W1820022443 cites W2066791265 @default.
• W1820022443 cites W2067840087 @default.
• W1820022443 cites W2068269731 @default.
• W1820022443 cites W2079454888 @default.
• W1820022443 cites W2086799111 @default.
• W1820022443 cites W2118061894 @default.
• W1820022443 cites W2121183119 @default.
• W1820022443 cites W2152918507 @default.
• W1820022443 cites W2154455036 @default.
• W1820022443 cites W2161957114 @default.
• W1820022443 cites W2190399324 @default.
• W1820022443 cites W2337139679 @default.
• W1820022443 cites W2397022730 @default.
• W1820022443 cites W2400718894 @default.
• W1820022443 cites W2402587517 @default.
• W1820022443 cites W2412212328 @default.
• W1820022443 cites W2792966232 @default.
• W1820022443 cites W4241181017 @default.
• W1820022443 cites W4244697632 @default.
• W1820022443 doi "https://doi.org/10.1111/j.1600-6143.2008.02448.x" @default.
• W1820022443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2756429" @default.
• W1820022443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18976300" @default.
• W1820022443 hasPublicationYear "2009" @default.
• W1820022443 type Work @default.
• W1820022443 sameAs 1820022443 @default.
• W1820022443 citedByCount "5" @default.
• W1820022443 countsByYear W18200224432013 @default.
• W1820022443 countsByYear W18200224432015 @default.
• W1820022443 crossrefType "journal-article" @default.
• W1820022443 hasAuthorship W1820022443A5003099842 @default.
• W1820022443 hasAuthorship W1820022443A5027966692 @default.
• W1820022443 hasAuthorship W1820022443A5049239788 @default.
• W1820022443 hasAuthorship W1820022443A5052066520 @default.
• W1820022443 hasAuthorship W1820022443A5056389032 @default.
• W1820022443 hasAuthorship W1820022443A5066614686 @default.
• W1820022443 hasAuthorship W1820022443A5069136593 @default.
• W1820022443 hasAuthorship W1820022443A5073028134 @default.
• W1820022443 hasBestOaLocation W18200224431 @default.
• W1820022443 hasConcept C126322002 @default.
• W1820022443 hasConcept C126894567 @default.
• W1820022443 hasConcept C203014093 @default.
• W1820022443 hasConcept C2777561873 @default.
• W1820022443 hasConcept C2777921159 @default.
• W1820022443 hasConcept C2778324207 @default.
• W1820022443 hasConcept C2779384505 @default.
• W1820022443 hasConcept C2780252810 @default.
• W1820022443 hasConcept C2909675724 @default.
• W1820022443 hasConcept C2911091166 @default.
• W1820022443 hasConcept C71924100 @default.
• W1820022443 hasConcept C90924648 @default.
• W1820022443 hasConceptScore W1820022443C126322002 @default.
• W1820022443 hasConceptScore W1820022443C126894567 @default.
• W1820022443 hasConceptScore W1820022443C203014093 @default.
• W1820022443 hasConceptScore W1820022443C2777561873 @default.
• W1820022443 hasConceptScore W1820022443C2777921159 @default.
• W1820022443 hasConceptScore W1820022443C2778324207 @default.
• W1820022443 hasConceptScore W1820022443C2779384505 @default.
• W1820022443 hasConceptScore W1820022443C2780252810 @default.
• W1820022443 hasConceptScore W1820022443C2909675724 @default.
• W1820022443 hasConceptScore W1820022443C2911091166 @default.
• W1820022443 hasConceptScore W1820022443C71924100 @default.
• W1820022443 hasConceptScore W1820022443C90924648 @default.
• W1820022443 hasIssue "1" @default.

• next