FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1820131134> ?p ?o ?g. }

• W1820131134 endingPage "220" @default.
• W1820131134 startingPage "214" @default.
• W1820131134 abstract "Recent studies have shown that parallel changes in body weight and bone mass can be partially mediated via circulating leptin. Therefore, among the hormones involved in bone and mineral metabolism, such as oestrogens, testosterone and parathormone, leptin has recently become a subject of considerable interest. The aim of this study was to assess associations between leptin, E(2), testosterone, dehydroepiandrosterone sulphate (DHEA-S), SHBG, alpha-ketoglutaric acid (AKG) and bone mineral density (BMD) and bone turnover markers in overweight and obese postmenopausal women.Eighty healthy, postmenopausal Caucasian women were studied. BMD of the lumbar spine (L(2)-L(4)) and femoral neck regions were examined using the dual X-ray absorptiometry (DXA) method. Associations were evaluated in stepwise multiple regression analysis, including information on the possible confounders and effect modifiers, for example, age, years since menopause, height and weight.Femoral neck BMD was positively correlated with weight (r = 0.52, P < 0.000001), body mass index (BMI) (r = 0.48, P < 0.000006), hipline (r = 0.48, P < 0.00006), waistline (r = 0.45, P < 0.00002) and DHEA-S (r = 0.36, P < 0.0008). Correlations of E(2), SHBG, testosterone and leptin, as well as biochemical markers of bone turnover with L(2)-L(4) and femoral neck BMD were not found. In the whole study group, significant predictors of L(2)-L(4 )BMD were BMI (beta = 0.35, P < 0.01) testosterone (beta = 0.27, P < 0.05) and osteocalcin (OC) (beta = 0.22, P < 0.05) (R(2) = 0.23), while predictors of femoral neck BMD were BMI (beta = 0.42, P < 0.001), testosterone (beta = 0.24, P < 0.05), E(2) (beta = 0.19, P < 0.05), as well as osteocalcin (beta = 0.20, P < 0.05) (R(2) = 0.41). In the subgroup with BMI 30-39.9, the significant predictors of both L(2)-L(4 )and femoral neck BMD were testosterone (beta = 0.32, P < 0.05, R(2) = 0.19; beta = 0.33, P < 0.05, R(2) = 0.29) and osteocalcin (beta = 0.34, P < 0.05, R(2) = 0.19; beta = 0.45, P < 0.01, R(2) = 0.29). In the subgroup with waist : hip ratio (WHR > or = 0.85, the predictor of L(2)-L(4 )BMD was E(2) (beta = 0.38, P < 0.05) (R(2) = 0.21), whereas the predictors of femoral neck BMD were BMI (beta = 0.29, P < 0.05) and testosterone (beta = 0.35, P < 0.01) (R(2) = 0.36).The main endocrine variable predicting lumbar spine BMD in overweight and obese postmenopausal females was testosterone, while the main determinants of femoral neck BMD were both testosterone and E(2). No effect was found of serum leptin on examined indicators of bone status." @default.
• W1820131134 created "2016-06-24" @default.
• W1820131134 creator A5012885382 @default.
• W1820131134 creator A5038724313 @default.
• W1820131134 date "2009-01-19" @default.
• W1820131134 modified "2023-10-15" @default.
• W1820131134 title "Bone mineral density and bone turnover in relation to serum leptin, α-ketoglutarate and sex steroids in overweight and obese postmenopausal women" @default.
• W1820131134 cites W1967139773 @default.
• W1820131134 cites W1973102414 @default.
• W1820131134 cites W1978628867 @default.
• W1820131134 cites W1986324959 @default.
• W1820131134 cites W1987003441 @default.
• W1820131134 cites W1998436663 @default.
• W1820131134 cites W2001534254 @default.
• W1820131134 cites W2010252892 @default.
• W1820131134 cites W2010773654 @default.
• W1820131134 cites W2015107503 @default.
• W1820131134 cites W2015344075 @default.
• W1820131134 cites W2024215760 @default.
• W1820131134 cites W2024839085 @default.
• W1820131134 cites W2029690463 @default.
• W1820131134 cites W2032048770 @default.
• W1820131134 cites W2041965877 @default.
• W1820131134 cites W2042662487 @default.
• W1820131134 cites W2047014086 @default.
• W1820131134 cites W2051043424 @default.
• W1820131134 cites W2062766817 @default.
• W1820131134 cites W2070393006 @default.
• W1820131134 cites W2080243300 @default.
• W1820131134 cites W2081181637 @default.
• W1820131134 cites W2084548911 @default.
• W1820131134 cites W2085686177 @default.
• W1820131134 cites W2104912868 @default.
• W1820131134 cites W2113351446 @default.
• W1820131134 cites W2135657072 @default.
• W1820131134 cites W2142234884 @default.
• W1820131134 cites W2170506940 @default.
• W1820131134 cites W2171929497 @default.
• W1820131134 cites W2249320309 @default.
• W1820131134 cites W2335084303 @default.
• W1820131134 cites W49265214 @default.
• W1820131134 doi "https://doi.org/10.1111/j.1365-2265.2008.03313.x" @default.
• W1820131134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18547340" @default.
• W1820131134 hasPublicationYear "2009" @default.
• W1820131134 type Work @default.
• W1820131134 sameAs 1820131134 @default.
• W1820131134 citedByCount "25" @default.
• W1820131134 countsByYear W18201311342012 @default.
• W1820131134 countsByYear W18201311342013 @default.
• W1820131134 countsByYear W18201311342014 @default.
• W1820131134 countsByYear W18201311342015 @default.
• W1820131134 countsByYear W18201311342016 @default.
• W1820131134 countsByYear W18201311342017 @default.
• W1820131134 countsByYear W18201311342018 @default.
• W1820131134 countsByYear W18201311342021 @default.
• W1820131134 countsByYear W18201311342022 @default.
• W1820131134 crossrefType "journal-article" @default.
• W1820131134 hasAuthorship W1820131134A5012885382 @default.
• W1820131134 hasAuthorship W1820131134A5038724313 @default.
• W1820131134 hasConcept C126322002 @default.
• W1820131134 hasConcept C131075544 @default.
• W1820131134 hasConcept C134018914 @default.
• W1820131134 hasConcept C160160445 @default.
• W1820131134 hasConcept C170033053 @default.
• W1820131134 hasConcept C181199279 @default.
• W1820131134 hasConcept C185592680 @default.
• W1820131134 hasConcept C2775854910 @default.
• W1820131134 hasConcept C2776541429 @default.
• W1820131134 hasConcept C2776886416 @default.
• W1820131134 hasConcept C2779279991 @default.
• W1820131134 hasConcept C2779329777 @default.
• W1820131134 hasConcept C2780221984 @default.
• W1820131134 hasConcept C2780586474 @default.
• W1820131134 hasConcept C2780613262 @default.
• W1820131134 hasConcept C511355011 @default.
• W1820131134 hasConcept C55493867 @default.
• W1820131134 hasConcept C71924100 @default.
• W1820131134 hasConceptScore W1820131134C126322002 @default.
• W1820131134 hasConceptScore W1820131134C131075544 @default.
• W1820131134 hasConceptScore W1820131134C134018914 @default.
• W1820131134 hasConceptScore W1820131134C160160445 @default.
• W1820131134 hasConceptScore W1820131134C170033053 @default.
• W1820131134 hasConceptScore W1820131134C181199279 @default.
• W1820131134 hasConceptScore W1820131134C185592680 @default.
• W1820131134 hasConceptScore W1820131134C2775854910 @default.
• W1820131134 hasConceptScore W1820131134C2776541429 @default.
• W1820131134 hasConceptScore W1820131134C2776886416 @default.
• W1820131134 hasConceptScore W1820131134C2779279991 @default.
• W1820131134 hasConceptScore W1820131134C2779329777 @default.
• W1820131134 hasConceptScore W1820131134C2780221984 @default.
• W1820131134 hasConceptScore W1820131134C2780586474 @default.
• W1820131134 hasConceptScore W1820131134C2780613262 @default.
• W1820131134 hasConceptScore W1820131134C511355011 @default.
• W1820131134 hasConceptScore W1820131134C55493867 @default.
• W1820131134 hasConceptScore W1820131134C71924100 @default.
• W1820131134 hasIssue "2" @default.
• W1820131134 hasLocation W18201311341 @default.
• W1820131134 hasLocation W18201311342 @default.

• next