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- W1820163886 abstract "This chapter discusses that microglia have been viewed as the quiescent though potentially active arm of the innate immune response in the central nervous system (CNS). After injury, they become activated and migrate to the lesion site. The participation of activated CNS-resident microglia in the inflammatory response that follows traumatic injuries or chronic neurodegenerative diseases in the CNS has been viewed as detrimental. Attempts have been made to treat these conditions by anti-inflammatory therapy. The chapter suggests that microglia act as stand-by cells in the service of both the immune and the nervous systems. Yet, their ability to fully benefit damaged tissue rather than to be inactive or even destructive reflects their activation. They exercise their neural function by buffering harmful self-compounds, and clearing debris from the damaged site and their immune function by providing immune-related requirements for recovery. It also suggests that regulation is achieved by the operation of a T-cell mediated response directed against abundant self-antigens residing in the damaged site. Since this regulatory mechanism was found to be protective against harmful endogenous factors released as a result of the injury, boosting of an autoimmune response, while avoiding autoimmune disease induction, might constitute the basis for the development of a therapeutic vaccination against neurodegenerative or other brain-related diseases." @default.
- W1820163886 created "2016-06-24" @default.
- W1820163886 creator A5065834855 @default.
- W1820163886 date "2003-01-01" @default.
- W1820163886 modified "2023-09-25" @default.
- W1820163886 title "Control of microglial activity by protective autoimmunity" @default.
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