FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1820367062> ?p ?o ?g. }

• W1820367062 endingPage "1725" @default.
• W1820367062 startingPage "1718" @default.
• W1820367062 abstract "The intrinsic regeneration capacity of dorsal root ganglion (DRG) neurons can be activated after sciatic nerve injury, and peripheral nerve regeneration is a complex process regulated by multiple molecular responses and signaling pathways. Long non-coding RNAs (lncRNAs) are RNA transcripts > 200 nucleotides in length without protein-coding potential. They regulate gene expression at epigenetic, transcriptional and post-transcriptional levels, and are thus involved in many biological processes and human diseases. However, the role and mechanisms of lncRNAs in regulating the responses of DRG neurons to sciatic nerve injury are not fully investigated. We have previously analysed the expression profiles of lncRNAs and mRNAs in L4-6 DRGs, following rat sciatic nerve transection, by microarray analysis, and constructed a coexpression network of dysregulated lncRNAs and coding genes. In this study, one of these dysregulated lncRNAs, uc.217, was chosen for detailed examination of its expression changes and regulative functions in regenerative DRG neuronal outgrowth. Quantitative real-time PCR and in situ hybridisation confirmed that the expression of uc.217 was down-regulated in DRG neurons after sciatic nerve injury. Silencing of uc.217 expression by small interfering RNA could significantly promote neurite outgrowth in cultured DRG neurons. Moreover, bioinformatic analysis and experimental validation were performed to identify several potential targets of uc.217, which were involved in the regulation of DRG neuron outgrowth. Collectively, our results suggested that a new lncRNA, uc.217, played an important regulative role in peripheral nerve regeneration." @default.
• W1820367062 created "2016-06-24" @default.
• W1820367062 creator A5007404705 @default.
• W1820367062 creator A5010156020 @default.
• W1820367062 creator A5037677450 @default.
• W1820367062 creator A5038683970 @default.
• W1820367062 creator A5057967562 @default.
• W1820367062 creator A5066680855 @default.
• W1820367062 creator A5076466992 @default.
• W1820367062 creator A5088536927 @default.
• W1820367062 date "2015-06-19" @default.
• W1820367062 modified "2023-10-05" @default.
• W1820367062 title "Long non-coding RNA uc.217 regulates neurite outgrowth in dorsal root ganglion neurons following peripheral nerve injury" @default.
• W1820367062 cites W1954890063 @default.
• W1820367062 cites W1975847255 @default.
• W1820367062 cites W1976859420 @default.
• W1820367062 cites W1978967539 @default.
• W1820367062 cites W1979584236 @default.
• W1820367062 cites W1994630748 @default.
• W1820367062 cites W2000534582 @default.
• W1820367062 cites W2002397995 @default.
• W1820367062 cites W2012443366 @default.
• W1820367062 cites W2012935431 @default.
• W1820367062 cites W2014665031 @default.
• W1820367062 cites W2019122937 @default.
• W1820367062 cites W2022863488 @default.
• W1820367062 cites W2024078916 @default.
• W1820367062 cites W2028939491 @default.
• W1820367062 cites W2029127268 @default.
• W1820367062 cites W2037363723 @default.
• W1820367062 cites W2044672052 @default.
• W1820367062 cites W2054677853 @default.
• W1820367062 cites W2057094700 @default.
• W1820367062 cites W2059968749 @default.
• W1820367062 cites W2060414933 @default.
• W1820367062 cites W2060424507 @default.
• W1820367062 cites W2060524148 @default.
• W1820367062 cites W2085103168 @default.
• W1820367062 cites W2087377443 @default.
• W1820367062 cites W2087612661 @default.
• W1820367062 cites W2093404711 @default.
• W1820367062 cites W2094008098 @default.
• W1820367062 cites W2095788744 @default.
• W1820367062 cites W2117671996 @default.
• W1820367062 cites W2127202058 @default.
• W1820367062 cites W2130388134 @default.
• W1820367062 cites W2135398049 @default.
• W1820367062 cites W2142019735 @default.
• W1820367062 cites W2146236251 @default.
• W1820367062 cites W2149480053 @default.
• W1820367062 cites W2159739718 @default.
• W1820367062 doi "https://doi.org/10.1111/ejn.12966" @default.
• W1820367062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26032672" @default.
• W1820367062 hasPublicationYear "2015" @default.
• W1820367062 type Work @default.
• W1820367062 sameAs 1820367062 @default.
• W1820367062 citedByCount "50" @default.
• W1820367062 countsByYear W18203670622015 @default.
• W1820367062 countsByYear W18203670622016 @default.
• W1820367062 countsByYear W18203670622017 @default.
• W1820367062 countsByYear W18203670622018 @default.
• W1820367062 countsByYear W18203670622019 @default.
• W1820367062 countsByYear W18203670622020 @default.
• W1820367062 countsByYear W18203670622021 @default.
• W1820367062 countsByYear W18203670622022 @default.
• W1820367062 countsByYear W18203670622023 @default.
• W1820367062 crossrefType "journal-article" @default.
• W1820367062 hasAuthorship W1820367062A5007404705 @default.
• W1820367062 hasAuthorship W1820367062A5010156020 @default.
• W1820367062 hasAuthorship W1820367062A5037677450 @default.
• W1820367062 hasAuthorship W1820367062A5038683970 @default.
• W1820367062 hasAuthorship W1820367062A5057967562 @default.
• W1820367062 hasAuthorship W1820367062A5066680855 @default.
• W1820367062 hasAuthorship W1820367062A5076466992 @default.
• W1820367062 hasAuthorship W1820367062A5088536927 @default.
• W1820367062 hasConcept C104317684 @default.
• W1820367062 hasConcept C105702510 @default.
• W1820367062 hasConcept C113246987 @default.
• W1820367062 hasConcept C119056186 @default.
• W1820367062 hasConcept C145059251 @default.
• W1820367062 hasConcept C150194340 @default.
• W1820367062 hasConcept C169760540 @default.
• W1820367062 hasConcept C171056886 @default.
• W1820367062 hasConcept C202751555 @default.
• W1820367062 hasConcept C2775991916 @default.
• W1820367062 hasConcept C2776281502 @default.
• W1820367062 hasConcept C2776588550 @default.
• W1820367062 hasConcept C2776880756 @default.
• W1820367062 hasConcept C2780775167 @default.
• W1820367062 hasConcept C2781149210 @default.
• W1820367062 hasConcept C41091548 @default.
• W1820367062 hasConcept C54355233 @default.
• W1820367062 hasConcept C62203573 @default.
• W1820367062 hasConcept C67705224 @default.
• W1820367062 hasConcept C86803240 @default.
• W1820367062 hasConcept C95444343 @default.
• W1820367062 hasConceptScore W1820367062C104317684 @default.
• W1820367062 hasConceptScore W1820367062C105702510 @default.

• next