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- W1820380997 abstract "Publisher Summary Genetic and particle complexity vary greatly among different viruses, there are general requirements for the sustenance of the extracellular portion of the virus life cycle that are remarkably similar for all animal viruses. This chapter applies the minimalistic approach to explore the extracellular portion of the virus life cycle and uses the insect nodaviruses as the subject of investigation. Nodavirus life cycle reflects a complex series of highly controlled events that reflect the behavior of animal viruses in general. The information presented is obtained with biophysical methods including crystallography, electron microscopy, and kinetic studies as well as with site-directed mutagenesis and other techniques of molecular biology. The goals are to understand dynamic processes associated with the viral processes including assembly, receptor-mediated interactions, a more detailed description of RNA release, and structural transitions that occur as a particle enters the cell. These studies required new methods of approach including computational chemistry, time-resolved analyses with spectroscopy, mass spectrometry, single crystal and solution X-ray scattering, and electron microscopy." @default.
- W1820380997 created "2016-06-24" @default.
- W1820380997 creator A5026834279 @default.
- W1820380997 creator A5055763016 @default.
- W1820380997 creator A5078724396 @default.
- W1820380997 date "1998-01-01" @default.
- W1820380997 modified "2023-10-16" @default.
- W1820380997 title "The Structure and Function of Nodavirus Particles: A Paradigm for Understanding Chemical Biology" @default.
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- W1820380997 doi "https://doi.org/10.1016/s0065-3527(08)60812-x" @default.
- W1820380997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9521003" @default.
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