FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1820824149> ?p ?o ?g. }

• W1820824149 endingPage "H864" @default.
• W1820824149 startingPage "H854" @default.
• W1820824149 abstract "Pyruvate (PYR) improves cellular and organ function hypoxia and ischemia by stabilizing the reduced nicotinamide adenine dinucleotide redox state and cytosolic ATP phosphorylation potential. In this in vivo study, we evaluated the effects of intravenous pyruvate on neocortical function, indexes of the cytosolic redox state, cellular energy state, and ischemia during a prolonged (4 h) controlled arterial hemorrhage (40 mmHg) in swine. Thirty minutes after the onset of hemorrhagic shock, sodium PYR ( n = 8) was infused (0.5 g · kg −1 · h −1 ) to attain arterial levels of 5 mM. The volume and osmotic effects were matched with 10% NaCl [hypertonic saline (HTS)] ( n = 8) or 0.9% NaCl [normal saline (NS)] ( n = 8). During the hemorrhage protocol, the time to peak hemorrhage volume was significantly delayed in the PYR group compared with the HTS and NS groups (94 ± 5 vs. 73 ± 6 and 72 ± 4 min, P < 0.05). In addition to the early onset of the decompensatory phase of hemorrhagic shock, the complete return of the hemorrhage volume during decompensatory shock resulted in the death of five and four animals, respectively, in the HTS and NS groups. In contrast, in the PYR group, reinfusion of the hemorrhage volume was slower and all animals survived the 4-h hemorrhage protocol. During hemorrhage, the PYR group also exhibited improved cerebral cortical metabolic and function status. PYR slowed and reduced the rise in neocortical microdialysis levels of adenosine, inosine, and hypoxanthine and delayed the loss of cerebral cortical biopsy ATP and phosphocreatine content. This improvement in energetic status was evident in the improved preservation of the electrocorticogram in the PYR group. PYR also prevented the eightfold increase in the excitotoxic amino acid glutamate observed in the HTS group. The findings show that PYR administered after the onset of hemorrhagic shock markedly improves cerebral metabolic and functional status for at least 4 h." @default.
• W1820824149 created "2016-06-24" @default.
• W1820824149 creator A5002250466 @default.
• W1820824149 creator A5007316009 @default.
• W1820824149 creator A5026676194 @default.
• W1820824149 creator A5089474485 @default.
• W1820824149 creator A5090148754 @default.
• W1820824149 date "2001-08-01" @default.
• W1820824149 modified "2023-09-25" @default.
• W1820824149 title "Pyruvate improves cerebral metabolism during hemorrhagic shock" @default.
• W1820824149 cites W1533853049 @default.
• W1820824149 cites W1905600998 @default.
• W1820824149 cites W1917708460 @default.
• W1820824149 cites W1933759996 @default.
• W1820824149 cites W1978387821 @default.
• W1820824149 cites W1982370712 @default.
• W1820824149 cites W1984320062 @default.
• W1820824149 cites W1990665368 @default.
• W1820824149 cites W1992027674 @default.
• W1820824149 cites W1998976350 @default.
• W1820824149 cites W2004266373 @default.
• W1820824149 cites W2005790515 @default.
• W1820824149 cites W2006071625 @default.
• W1820824149 cites W2007200514 @default.
• W1820824149 cites W2016880051 @default.
• W1820824149 cites W2018740639 @default.
• W1820824149 cites W2019305764 @default.
• W1820824149 cites W2025184324 @default.
• W1820824149 cites W2030415364 @default.
• W1820824149 cites W2039045136 @default.
• W1820824149 cites W2045946146 @default.
• W1820824149 cites W2050101609 @default.
• W1820824149 cites W2056939450 @default.
• W1820824149 cites W2059971224 @default.
• W1820824149 cites W2064570219 @default.
• W1820824149 cites W2068905479 @default.
• W1820824149 cites W2074163519 @default.
• W1820824149 cites W2077441640 @default.
• W1820824149 cites W2085240206 @default.
• W1820824149 cites W2088625127 @default.
• W1820824149 cites W2107366065 @default.
• W1820824149 cites W2116034479 @default.
• W1820824149 cites W2116265281 @default.
• W1820824149 cites W2131316215 @default.
• W1820824149 cites W2324829729 @default.
• W1820824149 cites W2342792498 @default.
• W1820824149 cites W2398289402 @default.
• W1820824149 cites W2404139447 @default.
• W1820824149 cites W2419315724 @default.
• W1820824149 cites W4250743197 @default.
• W1820824149 cites W47390233 @default.
• W1820824149 doi "https://doi.org/10.1152/ajpheart.2001.281.2.h854" @default.
• W1820824149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11454591" @default.
• W1820824149 hasPublicationYear "2001" @default.
• W1820824149 type Work @default.
• W1820824149 sameAs 1820824149 @default.
• W1820824149 citedByCount "52" @default.
• W1820824149 countsByYear W18208241492012 @default.
• W1820824149 countsByYear W18208241492014 @default.
• W1820824149 countsByYear W18208241492015 @default.
• W1820824149 countsByYear W18208241492016 @default.
• W1820824149 countsByYear W18208241492017 @default.
• W1820824149 countsByYear W18208241492023 @default.
• W1820824149 crossrefType "journal-article" @default.
• W1820824149 hasAuthorship W1820824149A5002250466 @default.
• W1820824149 hasAuthorship W1820824149A5007316009 @default.
• W1820824149 hasAuthorship W1820824149A5026676194 @default.
• W1820824149 hasAuthorship W1820824149A5089474485 @default.
• W1820824149 hasAuthorship W1820824149A5090148754 @default.
• W1820824149 hasConcept C104317684 @default.
• W1820824149 hasConcept C126322002 @default.
• W1820824149 hasConcept C134018914 @default.
• W1820824149 hasConcept C181199279 @default.
• W1820824149 hasConcept C185592680 @default.
• W1820824149 hasConcept C2778626300 @default.
• W1820824149 hasConcept C2781116151 @default.
• W1820824149 hasConcept C2781300812 @default.
• W1820824149 hasConcept C2986317502 @default.
• W1820824149 hasConcept C2994266630 @default.
• W1820824149 hasConcept C3017567848 @default.
• W1820824149 hasConcept C42219234 @default.
• W1820824149 hasConcept C50156730 @default.
• W1820824149 hasConcept C512185932 @default.
• W1820824149 hasConcept C529278444 @default.
• W1820824149 hasConcept C541997718 @default.
• W1820824149 hasConcept C55493867 @default.
• W1820824149 hasConcept C71924100 @default.
• W1820824149 hasConceptScore W1820824149C104317684 @default.
• W1820824149 hasConceptScore W1820824149C126322002 @default.
• W1820824149 hasConceptScore W1820824149C134018914 @default.
• W1820824149 hasConceptScore W1820824149C181199279 @default.
• W1820824149 hasConceptScore W1820824149C185592680 @default.
• W1820824149 hasConceptScore W1820824149C2778626300 @default.
• W1820824149 hasConceptScore W1820824149C2781116151 @default.
• W1820824149 hasConceptScore W1820824149C2781300812 @default.
• W1820824149 hasConceptScore W1820824149C2986317502 @default.
• W1820824149 hasConceptScore W1820824149C2994266630 @default.
• W1820824149 hasConceptScore W1820824149C3017567848 @default.

• next