FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1821039314> ?p ?o ?g. }

• W1821039314 abstract "The course of multiple sclerosis (MS) is generally difficult to predict. This is due to the great inter-individual variability with respect to symptoms and disability status. An important prognostic endpoint for MS is the expected time to sustained disease progression. Using the Expanded Disability Status Scale (EDSS) this endpoint is here defined as a rise of 1.0 or 0.5 compared to baseline EDSS ( 5.5) which is confirmed for at least six months. The goal of this paper was threefold. It aimed at identifying covariates which significantly influence sustained progression, determining size and form of the effect of these covariates and estimating the survival curves for given predictors. To this end a piecewise exponential model utilizing piecewise constant hazard rates and a Poisson model were devised. In order to improve and simplify these models a method for piecewise linear parameterization of non-parametric generalized additive models (GAMs) was applied. The models included fixed and random effects, the posterior distribution was estimated using Markov Chain Monte Carlo methods (MCMC) as well as a penalized likelihood approach and variables were selected using Akaikes information criterium (AIC). The models were applied to data of placebo patients from worldwide clinical trials that are pooled in the database of the Sylvia Lawry Centre for Multiple Sclerosis Research (SLCMSR). Only with a pure exponential model and fixed effects, baseline EDSS and the number of relapses in the last 12 month before study entry had an effect on the hazard rate. For the piecewise exponential model with random study effects there was no effect of covariates on the hazard rate other than a slightly decreasing effect of time. This reflects the fact that unstable patients reach the event early and are therefore eliminated from the analysis (selection effect)." @default.
• W1821039314 created "2016-06-24" @default.
• W1821039314 creator A5000714765 @default.
• W1821039314 creator A5040924743 @default.
• W1821039314 creator A5061874072 @default.
• W1821039314 creator A5088639152 @default.
• W1821039314 date "2003-01-01" @default.
• W1821039314 modified "2023-09-23" @default.
• W1821039314 title "Analysis of the time to sustained progression in Multiple Sclerosis using generalised linear and additive models" @default.
• W1821039314 cites W1688518778 @default.
• W1821039314 cites W1967495697 @default.
• W1821039314 cites W1977599025 @default.
• W1821039314 cites W2021484063 @default.
• W1821039314 cites W2038428996 @default.
• W1821039314 cites W2069745333 @default.
• W1821039314 cites W2097669496 @default.
• W1821039314 cites W2119047368 @default.
• W1821039314 cites W2135338737 @default.
• W1821039314 cites W2328425223 @default.
• W1821039314 cites W2797583072 @default.
• W1821039314 cites W3014310718 @default.
• W1821039314 cites W987144911 @default.
• W1821039314 doi "https://doi.org/10.5282/ubm/epub.1729" @default.
• W1821039314 hasPublicationYear "2003" @default.
• W1821039314 type Work @default.
• W1821039314 sameAs 1821039314 @default.
• W1821039314 citedByCount "2" @default.
• W1821039314 countsByYear W18210393142012 @default.
• W1821039314 crossrefType "journal-article" @default.
• W1821039314 hasAuthorship W1821039314A5000714765 @default.
• W1821039314 hasAuthorship W1821039314A5040924743 @default.
• W1821039314 hasAuthorship W1821039314A5061874072 @default.
• W1821039314 hasAuthorship W1821039314A5088639152 @default.
• W1821039314 hasConcept C100906024 @default.
• W1821039314 hasConcept C105795698 @default.
• W1821039314 hasConcept C111350023 @default.
• W1821039314 hasConcept C117251300 @default.
• W1821039314 hasConcept C118552586 @default.
• W1821039314 hasConcept C118615104 @default.
• W1821039314 hasConcept C119043178 @default.
• W1821039314 hasConcept C126322002 @default.
• W1821039314 hasConcept C132525143 @default.
• W1821039314 hasConcept C134306372 @default.
• W1821039314 hasConcept C16012445 @default.
• W1821039314 hasConcept C163175372 @default.
• W1821039314 hasConcept C164660894 @default.
• W1821039314 hasConcept C168743327 @default.
• W1821039314 hasConcept C194648359 @default.
• W1821039314 hasConcept C19499675 @default.
• W1821039314 hasConcept C2780640218 @default.
• W1821039314 hasConcept C2780892749 @default.
• W1821039314 hasConcept C30549945 @default.
• W1821039314 hasConcept C33923547 @default.
• W1821039314 hasConcept C47458327 @default.
• W1821039314 hasConcept C50382708 @default.
• W1821039314 hasConcept C70519679 @default.
• W1821039314 hasConcept C71924100 @default.
• W1821039314 hasConcept C95190672 @default.
• W1821039314 hasConceptScore W1821039314C100906024 @default.
• W1821039314 hasConceptScore W1821039314C105795698 @default.
• W1821039314 hasConceptScore W1821039314C111350023 @default.
• W1821039314 hasConceptScore W1821039314C117251300 @default.
• W1821039314 hasConceptScore W1821039314C118552586 @default.
• W1821039314 hasConceptScore W1821039314C118615104 @default.
• W1821039314 hasConceptScore W1821039314C119043178 @default.
• W1821039314 hasConceptScore W1821039314C126322002 @default.
• W1821039314 hasConceptScore W1821039314C132525143 @default.
• W1821039314 hasConceptScore W1821039314C134306372 @default.
• W1821039314 hasConceptScore W1821039314C16012445 @default.
• W1821039314 hasConceptScore W1821039314C163175372 @default.
• W1821039314 hasConceptScore W1821039314C164660894 @default.
• W1821039314 hasConceptScore W1821039314C168743327 @default.
• W1821039314 hasConceptScore W1821039314C194648359 @default.
• W1821039314 hasConceptScore W1821039314C19499675 @default.
• W1821039314 hasConceptScore W1821039314C2780640218 @default.
• W1821039314 hasConceptScore W1821039314C2780892749 @default.
• W1821039314 hasConceptScore W1821039314C30549945 @default.
• W1821039314 hasConceptScore W1821039314C33923547 @default.
• W1821039314 hasConceptScore W1821039314C47458327 @default.
• W1821039314 hasConceptScore W1821039314C50382708 @default.
• W1821039314 hasConceptScore W1821039314C70519679 @default.
• W1821039314 hasConceptScore W1821039314C71924100 @default.
• W1821039314 hasConceptScore W1821039314C95190672 @default.
• W1821039314 hasLocation W18210393141 @default.
• W1821039314 hasOpenAccess W1821039314 @default.
• W1821039314 hasPrimaryLocation W18210393141 @default.
• W1821039314 hasRelatedWork W1554165042 @default.
• W1821039314 hasRelatedWork W1978613457 @default.
• W1821039314 hasRelatedWork W1981942656 @default.
• W1821039314 hasRelatedWork W2012845613 @default.
• W1821039314 hasRelatedWork W2013598621 @default.
• W1821039314 hasRelatedWork W2049119444 @default.
• W1821039314 hasRelatedWork W2052946410 @default.
• W1821039314 hasRelatedWork W2089539816 @default.
• W1821039314 hasRelatedWork W2118482010 @default.
• W1821039314 hasRelatedWork W2154502907 @default.
• W1821039314 hasRelatedWork W2168289333 @default.
• W1821039314 hasRelatedWork W2172028361 @default.
• W1821039314 hasRelatedWork W2183549758 @default.
• W1821039314 hasRelatedWork W2324607445 @default.

• next