FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1821163671> ?p ?o ?g. }

• W1821163671 endingPage "123" @default.
• W1821163671 startingPage "113" @default.
• W1821163671 abstract "Farnesyl diphosphate synthase (FPPS) catalyzes the condensation of the non-allylic diphosphate, isopentenyl diphosphate (IPP; C5), with the allylic diphosphate primer dimethylallyl diphosphate (DMAPP; C5) to generate the C15 prenyl chain (FPP) used for protein prenylation as well as sterol and terpene biosynthesis. Here, we designed and prepared a series of pyridinium bisphosphonate (PyrBP) compounds, with the aim of selectively inhibiting FPPS of the lepidopteran insect order. FPPSs of Drosophila melanogaster and the spruce budworm, Choristoneura fumiferana, were inhibited by several PyrBPs, and as hypothesized, larger bisphosphonates were more selective for the lepidopteran protein and completely inactive towards dipteran and vertebrate FPPSs. Cell growth of a D. melanogaster cell line was adversely affected by exposure to PyrPBs that were strongly inhibitory to insect FPPS, although their effect was less pronounced than that observed upon exposure to the electron transport disrupter, chlorfenapyr. To assess the impact of PyrBPs on lepidopteran insect growth and development, we performed feeding and topical studies, using the tobacco hornworm, Manduca sexta, as our insect model. The free acid form of a PyrBP and a known bisphosphonate inhibitor of vertebrate FPPS, alendronate, had little to no effect on larval M. sexta; however, the topical application of more lipophilic ester PyrBPs caused decreased growth, incomplete larval molting, cuticle darkening at the site of application, and for those insects that survived, the formation of larval-pupal hybrids. To gain a better understanding of the structural differences that produce selective lepidopteran FPPS inhibition, homology models of C. fumiferana and D. melanogaster FPPS (CfFPPS2, and DmFPPS) were prepared. Docking of substrates and PyrBPs demonstrates that differences at the -3 and -4 positions relative to the first aspartate rich motif (FARM) are important factors in the ability of the lepidopteran enzyme to produce homologous isoprenoid structure and to be selectively inhibited by larger PyrBPs." @default.
• W1821163671 created "2016-06-24" @default.
• W1821163671 creator A5026358207 @default.
• W1821163671 creator A5028579762 @default.
• W1821163671 creator A5040203648 @default.
• W1821163671 creator A5043838932 @default.
• W1821163671 creator A5044367710 @default.
• W1821163671 creator A5046770251 @default.
• W1821163671 creator A5056859703 @default.
• W1821163671 creator A5082237829 @default.
• W1821163671 creator A5084406978 @default.
• W1821163671 date "2015-08-01" @default.
• W1821163671 modified "2023-09-27" @default.
• W1821163671 title "Disruption of insect isoprenoid biosynthesis with pyridinium bisphosphonates" @default.
• W1821163671 cites W1968027703 @default.
• W1821163671 cites W1974033238 @default.
• W1821163671 cites W1974081179 @default.
• W1821163671 cites W1976573258 @default.
• W1821163671 cites W1984335997 @default.
• W1821163671 cites W1984691048 @default.
• W1821163671 cites W1987657458 @default.
• W1821163671 cites W1989126791 @default.
• W1821163671 cites W2002370668 @default.
• W1821163671 cites W2008329892 @default.
• W1821163671 cites W2008953319 @default.
• W1821163671 cites W2023402920 @default.
• W1821163671 cites W2023852551 @default.
• W1821163671 cites W2029392258 @default.
• W1821163671 cites W2037300146 @default.
• W1821163671 cites W2042989869 @default.
• W1821163671 cites W2043165163 @default.
• W1821163671 cites W2046190216 @default.
• W1821163671 cites W2050066735 @default.
• W1821163671 cites W2050352060 @default.
• W1821163671 cites W2050727300 @default.
• W1821163671 cites W2067863600 @default.
• W1821163671 cites W2072582607 @default.
• W1821163671 cites W2073908163 @default.
• W1821163671 cites W2080671298 @default.
• W1821163671 cites W2081526181 @default.
• W1821163671 cites W2081591682 @default.
• W1821163671 cites W2082231458 @default.
• W1821163671 cites W2088629994 @default.
• W1821163671 cites W2090125712 @default.
• W1821163671 cites W2092580882 @default.
• W1821163671 cites W2119936162 @default.
• W1821163671 cites W2124166505 @default.
• W1821163671 cites W2125563621 @default.
• W1821163671 cites W2126988742 @default.
• W1821163671 cites W2129248369 @default.
• W1821163671 cites W2132333914 @default.
• W1821163671 cites W2149852370 @default.
• W1821163671 cites W2166288791 @default.
• W1821163671 cites W2168606601 @default.
• W1821163671 cites W2172170054 @default.
• W1821163671 cites W2324956847 @default.
• W1821163671 cites W2409879336 @default.
• W1821163671 cites W2741770376 @default.
• W1821163671 doi "https://doi.org/10.1016/j.ibmb.2015.05.006" @default.
• W1821163671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26073627" @default.
• W1821163671 hasPublicationYear "2015" @default.
• W1821163671 type Work @default.
• W1821163671 sameAs 1821163671 @default.
• W1821163671 citedByCount "5" @default.
• W1821163671 countsByYear W18211636712017 @default.
• W1821163671 countsByYear W18211636712018 @default.
• W1821163671 countsByYear W18211636712019 @default.
• W1821163671 countsByYear W18211636712021 @default.
• W1821163671 crossrefType "journal-article" @default.
• W1821163671 hasAuthorship W1821163671A5026358207 @default.
• W1821163671 hasAuthorship W1821163671A5028579762 @default.
• W1821163671 hasAuthorship W1821163671A5040203648 @default.
• W1821163671 hasAuthorship W1821163671A5043838932 @default.
• W1821163671 hasAuthorship W1821163671A5044367710 @default.
• W1821163671 hasAuthorship W1821163671A5046770251 @default.
• W1821163671 hasAuthorship W1821163671A5056859703 @default.
• W1821163671 hasAuthorship W1821163671A5082237829 @default.
• W1821163671 hasAuthorship W1821163671A5084406978 @default.
• W1821163671 hasConcept C104317684 @default.
• W1821163671 hasConcept C181199279 @default.
• W1821163671 hasConcept C206103511 @default.
• W1821163671 hasConcept C2777612826 @default.
• W1821163671 hasConcept C2778487026 @default.
• W1821163671 hasConcept C2779982574 @default.
• W1821163671 hasConcept C2780104201 @default.
• W1821163671 hasConcept C2780312687 @default.
• W1821163671 hasConcept C2780361610 @default.
• W1821163671 hasConcept C553450214 @default.
• W1821163671 hasConcept C55493867 @default.
• W1821163671 hasConcept C59822182 @default.
• W1821163671 hasConcept C86803240 @default.
• W1821163671 hasConceptScore W1821163671C104317684 @default.
• W1821163671 hasConceptScore W1821163671C181199279 @default.
• W1821163671 hasConceptScore W1821163671C206103511 @default.
• W1821163671 hasConceptScore W1821163671C2777612826 @default.
• W1821163671 hasConceptScore W1821163671C2778487026 @default.
• W1821163671 hasConceptScore W1821163671C2779982574 @default.
• W1821163671 hasConceptScore W1821163671C2780104201 @default.

• next