Matches in SemOpenAlex for { <https://semopenalex.org/work/W1821275256> ?p ?o ?g. }
- W1821275256 endingPage "20512" @default.
- W1821275256 startingPage "20500" @default.
- W1821275256 abstract "Ovarian cancer is the most lethal gynecological malignancy, primarily because its origin and initiation factors are unknown. A secretory murine oviductal epithelial (MOE) model was generated to address the hypothesis that the fallopian tube is an origin for high-grade serous cancer. MOE cells were stably altered to express mutation in p53, silence PTEN, activate AKT, and amplify KRAS alone and in combination, to define if this cell type gives rise to tumors and what genetic alterations are required to drive malignancy. Cell lines were characterized in vitro and allografted into mice. Silencing PTEN formed high-grade carcinoma with wide spread tumor explants including metastasis into the ovary. Addition of p53 mutation to PTEN silencing did not enhance this phenotype, whereas addition of KRAS mutation reduced survival. Interestingly, PTEN silencing and KRAS mutation originating from ovarian surface epithelium generated endometrioid carcinoma, suggesting that different cellular origins with identical genetic manipulations can give rise to distinct cancer histotypes. Defining the roles of specific signaling modifications in tumorigenesis from the fallopian tube/oviduct is essential for early detection and development of targeted therapeutics. Further, syngeneic MOE allografts provide an ideal model for pre-clinical testing in an in vivo environment with an intact immune system." @default.
- W1821275256 created "2016-06-24" @default.
- W1821275256 creator A5013239573 @default.
- W1821275256 creator A5027173430 @default.
- W1821275256 creator A5027586857 @default.
- W1821275256 creator A5035497785 @default.
- W1821275256 creator A5039075996 @default.
- W1821275256 creator A5063644907 @default.
- W1821275256 creator A5068626380 @default.
- W1821275256 creator A5085229257 @default.
- W1821275256 date "2015-05-04" @default.
- W1821275256 modified "2023-10-18" @default.
- W1821275256 title "Tumorigenesis and peritoneal colonization from fallopian tube epithelium" @default.
- W1821275256 cites W1815076720 @default.
- W1821275256 cites W1838303237 @default.
- W1821275256 cites W1889202581 @default.
- W1821275256 cites W1978597789 @default.
- W1821275256 cites W1989297523 @default.
- W1821275256 cites W1992772472 @default.
- W1821275256 cites W2001605681 @default.
- W1821275256 cites W2003027334 @default.
- W1821275256 cites W2013107316 @default.
- W1821275256 cites W2023255018 @default.
- W1821275256 cites W2026674119 @default.
- W1821275256 cites W2036242349 @default.
- W1821275256 cites W2051023783 @default.
- W1821275256 cites W2068085420 @default.
- W1821275256 cites W2071014344 @default.
- W1821275256 cites W2074860448 @default.
- W1821275256 cites W2109689528 @default.
- W1821275256 cites W2118244388 @default.
- W1821275256 cites W2118667301 @default.
- W1821275256 cites W2120026123 @default.
- W1821275256 cites W2123696077 @default.
- W1821275256 cites W2125370994 @default.
- W1821275256 cites W2133955927 @default.
- W1821275256 cites W2135838271 @default.
- W1821275256 cites W2136544650 @default.
- W1821275256 cites W2138202356 @default.
- W1821275256 cites W2138304815 @default.
- W1821275256 cites W2144894645 @default.
- W1821275256 cites W2153009342 @default.
- W1821275256 cites W2155341026 @default.
- W1821275256 cites W2162393230 @default.
- W1821275256 cites W2169961966 @default.
- W1821275256 cites W2171581152 @default.
- W1821275256 cites W2219978888 @default.
- W1821275256 doi "https://doi.org/10.18632/oncotarget.3985" @default.
- W1821275256 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4653021" @default.
- W1821275256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25971410" @default.
- W1821275256 hasPublicationYear "2015" @default.
- W1821275256 type Work @default.
- W1821275256 sameAs 1821275256 @default.
- W1821275256 citedByCount "31" @default.
- W1821275256 countsByYear W18212752562016 @default.
- W1821275256 countsByYear W18212752562017 @default.
- W1821275256 countsByYear W18212752562018 @default.
- W1821275256 countsByYear W18212752562019 @default.
- W1821275256 countsByYear W18212752562020 @default.
- W1821275256 countsByYear W18212752562021 @default.
- W1821275256 countsByYear W18212752562022 @default.
- W1821275256 countsByYear W18212752562023 @default.
- W1821275256 crossrefType "journal-article" @default.
- W1821275256 hasAuthorship W1821275256A5013239573 @default.
- W1821275256 hasAuthorship W1821275256A5027173430 @default.
- W1821275256 hasAuthorship W1821275256A5027586857 @default.
- W1821275256 hasAuthorship W1821275256A5035497785 @default.
- W1821275256 hasAuthorship W1821275256A5039075996 @default.
- W1821275256 hasAuthorship W1821275256A5063644907 @default.
- W1821275256 hasAuthorship W1821275256A5068626380 @default.
- W1821275256 hasAuthorship W1821275256A5085229257 @default.
- W1821275256 hasBestOaLocation W18212752561 @default.
- W1821275256 hasConcept C104317684 @default.
- W1821275256 hasConcept C119056186 @default.
- W1821275256 hasConcept C121608353 @default.
- W1821275256 hasConcept C142724271 @default.
- W1821275256 hasConcept C2777609662 @default.
- W1821275256 hasConcept C2779013556 @default.
- W1821275256 hasConcept C2780427987 @default.
- W1821275256 hasConcept C2781187634 @default.
- W1821275256 hasConcept C502942594 @default.
- W1821275256 hasConcept C526805850 @default.
- W1821275256 hasConcept C54355233 @default.
- W1821275256 hasConcept C555283112 @default.
- W1821275256 hasConcept C62478195 @default.
- W1821275256 hasConcept C71924100 @default.
- W1821275256 hasConcept C86554907 @default.
- W1821275256 hasConcept C86803240 @default.
- W1821275256 hasConcept C95444343 @default.
- W1821275256 hasConceptScore W1821275256C104317684 @default.
- W1821275256 hasConceptScore W1821275256C119056186 @default.
- W1821275256 hasConceptScore W1821275256C121608353 @default.
- W1821275256 hasConceptScore W1821275256C142724271 @default.
- W1821275256 hasConceptScore W1821275256C2777609662 @default.
- W1821275256 hasConceptScore W1821275256C2779013556 @default.
- W1821275256 hasConceptScore W1821275256C2780427987 @default.
- W1821275256 hasConceptScore W1821275256C2781187634 @default.
- W1821275256 hasConceptScore W1821275256C502942594 @default.