Matches in SemOpenAlex for { <https://semopenalex.org/work/W182151585> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W182151585 endingPage "64" @default.
- W182151585 startingPage "57" @default.
- W182151585 abstract "In order to prolong shelf-life and improve the quality of the vaccine product, not only an effective stabilizer but also a more proper dosage form has been sought. The stability of a Japanese encephalitis (JE) vaccine produced from mouse brain along with a variety of stabilizers and lyophilization protocols was evaluated. Without any stabilizers added, almost 90% of the antigenicity would vanish after freeze-drying process. Comparative studies of various compounds, including carbohydrates, amino acids, peptides and medium 199, on both antigenicity preservation and thermostability of the vaccine were carried out. The results indicated that the best reconstituted vaccines were prepared with two stabilizer formulations, sucrose and sucrose/gelatin. They were further examined by accelerated stability test at room and higher temperatures. The sucrose-added lyophilized vaccine can retain its original antigenicity for more than 60 days both at 37 degrees C and 45 degrees C. We conclude the thermostability efficiency of each of the stabilizers tested is as that follows: sucrose > sucrose/gelatin > gelatin/medium > gelatin." @default.
- W182151585 created "2016-06-24" @default.
- W182151585 creator A5000866313 @default.
- W182151585 creator A5012724696 @default.
- W182151585 creator A5017712508 @default.
- W182151585 creator A5025087234 @default.
- W182151585 creator A5036521563 @default.
- W182151585 creator A5037335678 @default.
- W182151585 date "1996-02-01" @default.
- W182151585 modified "2023-10-03" @default.
- W182151585 title "[Study on the stability of Japanese encephalitis vaccine--development of freeze-dry dosage form]." @default.
- W182151585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10592787" @default.
- W182151585 hasPublicationYear "1996" @default.
- W182151585 type Work @default.
- W182151585 sameAs 182151585 @default.
- W182151585 citedByCount "1" @default.
- W182151585 countsByYear W1821515852019 @default.
- W182151585 crossrefType "journal-article" @default.
- W182151585 hasAuthorship W182151585A5000866313 @default.
- W182151585 hasAuthorship W182151585A5012724696 @default.
- W182151585 hasAuthorship W182151585A5017712508 @default.
- W182151585 hasAuthorship W182151585A5025087234 @default.
- W182151585 hasAuthorship W182151585A5036521563 @default.
- W182151585 hasAuthorship W182151585A5037335678 @default.
- W182151585 hasConcept C127413603 @default.
- W182151585 hasConcept C159047783 @default.
- W182151585 hasConcept C159654299 @default.
- W182151585 hasConcept C181199279 @default.
- W182151585 hasConcept C185592680 @default.
- W182151585 hasConcept C203014093 @default.
- W182151585 hasConcept C2522874641 @default.
- W182151585 hasConcept C2777502316 @default.
- W182151585 hasConcept C2778540732 @default.
- W182151585 hasConcept C2778597767 @default.
- W182151585 hasConcept C2778823387 @default.
- W182151585 hasConcept C2779026604 @default.
- W182151585 hasConcept C2779141303 @default.
- W182151585 hasConcept C2781216036 @default.
- W182151585 hasConcept C31903555 @default.
- W182151585 hasConcept C43617362 @default.
- W182151585 hasConcept C55493867 @default.
- W182151585 hasConcept C78519656 @default.
- W182151585 hasConcept C83455156 @default.
- W182151585 hasConcept C84199377 @default.
- W182151585 hasConcept C86803240 @default.
- W182151585 hasConceptScore W182151585C127413603 @default.
- W182151585 hasConceptScore W182151585C159047783 @default.
- W182151585 hasConceptScore W182151585C159654299 @default.
- W182151585 hasConceptScore W182151585C181199279 @default.
- W182151585 hasConceptScore W182151585C185592680 @default.
- W182151585 hasConceptScore W182151585C203014093 @default.
- W182151585 hasConceptScore W182151585C2522874641 @default.
- W182151585 hasConceptScore W182151585C2777502316 @default.
- W182151585 hasConceptScore W182151585C2778540732 @default.
- W182151585 hasConceptScore W182151585C2778597767 @default.
- W182151585 hasConceptScore W182151585C2778823387 @default.
- W182151585 hasConceptScore W182151585C2779026604 @default.
- W182151585 hasConceptScore W182151585C2779141303 @default.
- W182151585 hasConceptScore W182151585C2781216036 @default.
- W182151585 hasConceptScore W182151585C31903555 @default.
- W182151585 hasConceptScore W182151585C43617362 @default.
- W182151585 hasConceptScore W182151585C55493867 @default.
- W182151585 hasConceptScore W182151585C78519656 @default.
- W182151585 hasConceptScore W182151585C83455156 @default.
- W182151585 hasConceptScore W182151585C84199377 @default.
- W182151585 hasConceptScore W182151585C86803240 @default.
- W182151585 hasIssue "1" @default.
- W182151585 hasLocation W1821515851 @default.
- W182151585 hasOpenAccess W182151585 @default.
- W182151585 hasPrimaryLocation W1821515851 @default.
- W182151585 hasRelatedWork W182151585 @default.
- W182151585 hasRelatedWork W2020347120 @default.
- W182151585 hasRelatedWork W2359556121 @default.
- W182151585 hasRelatedWork W2364092337 @default.
- W182151585 hasRelatedWork W2373649843 @default.
- W182151585 hasRelatedWork W2380641723 @default.
- W182151585 hasRelatedWork W2392348463 @default.
- W182151585 hasRelatedWork W3087649764 @default.
- W182151585 hasRelatedWork W3120286178 @default.
- W182151585 hasRelatedWork W3126933580 @default.
- W182151585 hasVolume "29" @default.
- W182151585 isParatext "false" @default.
- W182151585 isRetracted "false" @default.
- W182151585 magId "182151585" @default.
- W182151585 workType "article" @default.