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- W1821582401 endingPage "30" @default.
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- W1821582401 abstract "The amyloid fibrils deposited in Alzheimer's neuritic plaque cores and cerebral blood vessels are mainly composed of aggregated forms of a unique peptide, 39-42 amino acids long, named amyloid beta (A beta). A similar, although soluble, A beta (‘sA beta’) has been identified in cerebrospinal fluid, plasma and cell supernatants, indicating that it is normally produced by proteolytic processing of its precursor protein, amyloid precursor protein (APP). Using direct binding experiments we have isolated and characterized an 80 kDa circulating protein that specifically interacts with a synthetic peptide identical with A beta. The protein was unmistakably identified as SP-40,40 or ApoJ, a cytolytic inhibitor and lipid carrier, by means of amino acid sequence and immunoreactivity with specific antibodies. Immunoprecipitation with anti-SP-40,40 retrieved soluble A beta from cerebrospinal fluid, indicating that the interaction occurs in vivo." @default.
- W1821582401 created "2016-06-24" @default.
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- W1821582401 date "1993-07-01" @default.
- W1821582401 modified "2023-09-30" @default.
- W1821582401 title "The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex" @default.
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- W1821582401 doi "https://doi.org/10.1042/bj2930027" @default.
- W1821582401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1134315" @default.
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