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• W1821583325 endingPage "083016" @default.
• W1821583325 startingPage "083016" @default.
• W1821583325 abstract "Macromolecular complexation leading to coupling of two or more cellular membranes is a crucial step in a number of biological functions of the cell. While other mechanisms may also play a role, adhesion always involves the fluctuations of deformable membranes, the diffusion of proteins and the molecular binding and unbinding. Because these stochastic processes couple over a multitude of time and length scales, theoretical modeling of membrane adhesion has been a major challenge. Here we present an effective Monte Carlo scheme within which the effects of the membrane are integrated into local rates for molecular recognition. The latter step in the Monte Carlo approach enables us to simulate the nucleation and growth of adhesion domains within a system of the size of a cell for tens of seconds without loss of accuracy, as shown by comparison to 106 times more expensive Langevin simulations. To perform this validation, the Langevin approach was augmented to simulate diffusion of proteins explicitly, together with reaction kinetics and membrane dynamics. We use the Monte Carlo scheme to gain deeper insight to the experimentally observed radial growth of micron sized adhesion domains, and connect the effective rate with which the domain is growing to the underlying microscopic events. We thus demonstrate that our technique yields detailed information about protein transport and complexation in membranes, which is a fundamental step toward understanding even more complex membrane interactions in the cellular context." @default.
• W1821583325 created "2016-06-24" @default.
• W1821583325 creator A5010989324 @default.
• W1821583325 creator A5033252464 @default.
• W1821583325 creator A5080004413 @default.
• W1821583325 date "2015-08-10" @default.
• W1821583325 modified "2023-10-18" @default.
• W1821583325 title "Multiscale approaches to protein-mediated interactions between membranes—relating microscopic and macroscopic dynamics in radially growing adhesions" @default.
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• W1821583325 doi "https://doi.org/10.1088/1367-2630/17/8/083016" @default.
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