Matches in SemOpenAlex for { <https://semopenalex.org/work/W1821981622> ?p ?o ?g. }
- W1821981622 endingPage "e575" @default.
- W1821981622 startingPage "e564" @default.
- W1821981622 abstract "Most studies of the causes of diarrhoea in low-income and middle-income countries have looked at severe disease in people presenting for care, and there are few estimates of pathogen-specific diarrhoea burdens in the community.We undertook a birth cohort study with not only intensive community surveillance for diarrhoea but also routine collection of non-diarrhoeal stools from eight sites in South America, Africa, and Asia. We enrolled children within 17 days of birth, and diarrhoeal episodes (defined as maternal report of three or more loose stools in 24 h, or one loose stool with visible blood) were identified through twice-weekly home visits by fieldworkers over a follow-up period of 24 months. Non-diarrhoeal stool specimens were also collected for surveillance for months 1-12, 15, 18, 21, and 24. Stools were analysed for a broad range of enteropathogens using culture, enzyme immunoassay, and PCR. We used the adjusted attributable fraction (AF) to estimate pathogen-specific burdens of diarrhoea.Between November 26, 2009, and February 25, 2014, we tested 7318 diarrhoeal and 24 310 non-diarrhoeal stools collected from 2145 children aged 0-24 months. Pathogen detection was common in non-diarrhoeal stools but was higher with diarrhoea. Norovirus GII (AF 5·2%, 95% CI 3·0-7·1), rotavirus (4·8%, 4·5-5·0), Campylobacter spp (3·5%, 0·4-6·3), astrovirus (2·7%, 2·2-3·1), and Cryptosporidium spp (2·0%, 1·3-2·6) exhibited the highest attributable burdens of diarrhoea in the first year of life. The major pathogens associated with diarrhoea in the second year of life were Campylobacter spp (7·9%, 3·1-12·1), norovirus GII (5·4%, 2·1-7·8), rotavirus (4·9%, 4·4-5·2), astrovirus (4·2%, 3·5-4·7), and Shigella spp (4·0%, 3·6-4·3). Rotavirus had the highest AF for sites without rotavirus vaccination and the fifth highest AF for sites with the vaccination. There was substantial variation in pathogens according to geography, diarrhoea severity, and season. Bloody diarrhoea was primarily associated with Campylobacter spp and Shigella spp, fever and vomiting with rotavirus, and vomiting with norovirus GII.There was substantial heterogeneity in pathogen-specific burdens of diarrhoea, with important determinants including age, geography, season, rotavirus vaccine usage, and symptoms. These findings suggest that although single-pathogen strategies have an important role in the reduction of the burden of severe diarrhoeal disease, the effect of such interventions on total diarrhoeal incidence at the community level might be limited." @default.
- W1821981622 created "2016-06-24" @default.
- W1821981622 creator A5003865904 @default.
- W1821981622 creator A5007061685 @default.
- W1821981622 creator A5007853642 @default.
- W1821981622 creator A5008670253 @default.
- W1821981622 creator A5008790762 @default.
- W1821981622 creator A5008883499 @default.
- W1821981622 creator A5011924977 @default.
- W1821981622 creator A5013287011 @default.
- W1821981622 creator A5018075489 @default.
- W1821981622 creator A5018743845 @default.
- W1821981622 creator A5018763815 @default.
- W1821981622 creator A5019190166 @default.
- W1821981622 creator A5024473138 @default.
- W1821981622 creator A5038738718 @default.
- W1821981622 creator A5039433364 @default.
- W1821981622 creator A5039674482 @default.
- W1821981622 creator A5041338997 @default.
- W1821981622 creator A5041405457 @default.
- W1821981622 creator A5042161750 @default.
- W1821981622 creator A5042853615 @default.
- W1821981622 creator A5043728694 @default.
- W1821981622 creator A5051818098 @default.
- W1821981622 creator A5067727182 @default.
- W1821981622 creator A5067998146 @default.
- W1821981622 creator A5068198671 @default.
- W1821981622 creator A5069940679 @default.
- W1821981622 creator A5071031273 @default.
- W1821981622 creator A5071816628 @default.
- W1821981622 creator A5073387169 @default.
- W1821981622 creator A5074176635 @default.
- W1821981622 creator A5081116359 @default.
- W1821981622 creator A5084152395 @default.
- W1821981622 creator A5084419236 @default.
- W1821981622 creator A5085793844 @default.
- W1821981622 creator A5087299636 @default.
- W1821981622 creator A5090424264 @default.
- W1821981622 date "2015-09-01" @default.
- W1821981622 modified "2023-10-14" @default.
- W1821981622 title "Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)" @default.
- W1821981622 cites W1495177956 @default.
- W1821981622 cites W1622938183 @default.
- W1821981622 cites W1966443760 @default.
- W1821981622 cites W1968820836 @default.
- W1821981622 cites W1989645075 @default.
- W1821981622 cites W2005096288 @default.
- W1821981622 cites W2012807335 @default.
- W1821981622 cites W2023486393 @default.
- W1821981622 cites W2049555255 @default.
- W1821981622 cites W2056335477 @default.
- W1821981622 cites W2057022620 @default.
- W1821981622 cites W2058832248 @default.
- W1821981622 cites W2061702680 @default.
- W1821981622 cites W2070133496 @default.
- W1821981622 cites W2078497184 @default.
- W1821981622 cites W2084993967 @default.
- W1821981622 cites W2088832736 @default.
- W1821981622 cites W2090581308 @default.
- W1821981622 cites W2094688293 @default.
- W1821981622 cites W2096285912 @default.
- W1821981622 cites W2103643850 @default.
- W1821981622 cites W2111639351 @default.
- W1821981622 cites W2114053580 @default.
- W1821981622 cites W2117817457 @default.
- W1821981622 cites W2128885064 @default.
- W1821981622 cites W2130754549 @default.
- W1821981622 cites W2142210776 @default.
- W1821981622 cites W2145542895 @default.
- W1821981622 cites W2150169200 @default.
- W1821981622 cites W2153522309 @default.
- W1821981622 cites W2155168310 @default.
- W1821981622 cites W2155954662 @default.
- W1821981622 cites W2168866014 @default.
- W1821981622 cites W2169633931 @default.
- W1821981622 cites W2171156537 @default.
- W1821981622 cites W2172111132 @default.
- W1821981622 cites W2256786579 @default.
- W1821981622 doi "https://doi.org/10.1016/s2214-109x(15)00151-5" @default.
- W1821981622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7328884" @default.
- W1821981622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26202075" @default.
- W1821981622 hasPublicationYear "2015" @default.
- W1821981622 type Work @default.
- W1821981622 sameAs 1821981622 @default.
- W1821981622 citedByCount "659" @default.
- W1821981622 countsByYear W18219816222015 @default.
- W1821981622 countsByYear W18219816222016 @default.
- W1821981622 countsByYear W18219816222017 @default.
- W1821981622 countsByYear W18219816222018 @default.
- W1821981622 countsByYear W18219816222019 @default.
- W1821981622 countsByYear W18219816222020 @default.
- W1821981622 countsByYear W18219816222021 @default.
- W1821981622 countsByYear W18219816222022 @default.
- W1821981622 countsByYear W18219816222023 @default.
- W1821981622 crossrefType "journal-article" @default.
- W1821981622 hasAuthorship W1821981622A5003865904 @default.
- W1821981622 hasAuthorship W1821981622A5007061685 @default.
- W1821981622 hasAuthorship W1821981622A5007853642 @default.