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• W1822103663 startingPage "669" @default.
• W1822103663 abstract "Enterohaemorrhagic Escherichia coli O157:H7 harbours a cryptic plasmid, pOSAK1, that carries only three ORFs: mobA (involved in plasmid mobilization), ORF1 and ORF2. Predicted proteins encoded by these two ORFs were found to share a weak homology with RnlA and RnlB, respectively, a toxin–antitoxin system encoded on the E. coli K-12 chromosome. Here, we report that lsoA (ORF1) encodes a toxin and lsoB (ORF2) an antitoxin. In spite of the homologies, RnlB and LsoB functioned as antitoxins against only their cognate toxins and not interchangeably with each other. Interestingly, T4 phage Dmd suppressed the toxicities of both RnlA and LsoA by direct interaction, the first example of a phage with an antitoxin against multiple toxins." @default.
• W1822103663 created "2016-06-24" @default.
• W1822103663 creator A5020139068 @default.
• W1822103663 creator A5054120210 @default.
• W1822103663 date "2012-01-18" @default.
• W1822103663 modified "2023-09-30" @default.
• W1822103663 title "Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins" @default.
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• W1822103663 doi "https://doi.org/10.1111/j.1365-2958.2012.07975.x" @default.
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