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- W1822418086 abstract "Diurnal metabolic rhythms add an important temporal dimension to metabolic homeostasis in mammals. Although it remains a challenge to untangle the intricate networks of crosstalk among the body clock, nutrient signalling and tissue metabolism, there is little doubt that the rhythmic nature of nutrient and energy metabolism is a central aspect of metabolic physiology. Disruption of the synchrony between clock and metabolism has been causally linked to diverse pathophysiological states. As such, restoring the rhythmicity of body physiology and therapeutic targeting directed at specific time windows during the day may have important implications in human health and medicine. In this review, we summarize recent findings on the integration of hepatic glucose metabolism and the body clock through a regulatory network centred on the PPARγ coactivator 1 (PGC-1) transcriptional coactivators. In addition, we discuss the transcriptional mechanisms underlying circadian control of the autophagy gene programme and autophagy in the liver." @default.
- W1822418086 created "2016-06-24" @default.
- W1822418086 creator A5034855042 @default.
- W1822418086 creator A5078344689 @default.
- W1822418086 date "2015-09-01" @default.
- W1822418086 modified "2023-10-06" @default.
- W1822418086 title "Transcriptional control of circadian metabolic rhythms in the liver" @default.
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- W1822418086 doi "https://doi.org/10.1111/dom.12520" @default.
- W1822418086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4562072" @default.
- W1822418086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26332966" @default.
- W1822418086 hasPublicationYear "2015" @default.
- W1822418086 type Work @default.