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• W1822429536 abstract "p31comet plays an important role in spindle assembly checkpoint (SAC) silencing. However, how p31comet's activity is regulated remains unclear. Here we show that the timing of M-phase exit in Xenopus egg extracts (XEEs) depends upon SAC activity, even under conditions that are permissive for spindle assembly. p31comet antagonizes the SAC, promoting XEE progression into anaphase after spindles are fully formed. We further show that mitotic p31comet phosphorylation by Inhibitor of nuclear factor κ-B kinase-β (IKK-β) enhances this role in SAC silencing. Together, our findings implicate IKK-β in the control of anaphase timing in XEE through p31comet activation and SAC downregulation." @default.
• W1822429536 created "2016-06-24" @default.
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• W1822429536 creator A5056827907 @default.
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• W1822429536 date "2015-12-17" @default.
• W1822429536 modified "2023-09-27" @default.
• W1822429536 title "Phosphorylation of Xenopus p31comet potentiates mitotic checkpoint exit" @default.
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• W1822429536 doi "https://doi.org/10.1080/15384101.2015.1033590" @default.
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