FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1822463313> ?p ?o ?g. }

• W1822463313 endingPage "270" @default.
• W1822463313 startingPage "251" @default.
• W1822463313 abstract "Mantle cell lymphoma (MCL) is a distinct B-cell non-Hodgkin's lymphoma (NHL) defined by the translocation t(11;14). MCL combines characteristics of both indolent and aggressive lymphomas, and it is incurable with conventional chemoimmunotherapy but has a more aggressive disease course. Minimal data exist on treatment of patients diagnosed with early-stage disease (stage I-II non-bulky), as this represents only a small portion of the patients diagnosed with MCL, but therapeutic options evaluated in retrospective studies include radiation or combination radiation and chemotherapy. There is a subset of patients with newly diagnosed MCL that can be observed without treatment, but the majority of patients will require treatment at diagnosis. Treatment is often based on age (≤65-70 years of age), comorbidities, and risk factors for disease. The majority of patients who are younger and without significant comorbidities are treated with intensive induction using combination chemoimmunotherapy regimens, many which include consolidation with autologous stem cell transplant (ASCT). Several regimens have been studied that show improved median progression-free survival (PFS) to 3-6 years in this population of patients. The majority of older patients (≥65-70 years of age) are treated with combination chemoimmunotherapy regimens with consideration of rituximab maintenance, with enrollment on a clinical trial encouraged. Therapy for relapsed disease is dependent on prior treatment, age, comorbidities, and toxicities but includes targeted therapies such as the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, the immunomodulatory agent lenalidomide, the proteasome inhibitor bortezomib, combination chemoimmunotherapy, ASCT, and allogeneic stem cell transplant in selected cases. Several novel agents and targeted therapies alone or in combination are currently being studied and developed in both the upfront and relapsed setting." @default.
• W1822463313 created "2016-06-24" @default.
• W1822463313 creator A5024389256 @default.
• W1822463313 creator A5056946123 @default.
• W1822463313 date "2015-01-01" @default.
• W1822463313 modified "2023-09-27" @default.
• W1822463313 title "Treatment Strategies in Mantle Cell Lymphoma" @default.
• W1822463313 cites W1549556227 @default.
• W1822463313 cites W188371898 @default.
• W1822463313 cites W1945251789 @default.
• W1822463313 cites W1985343909 @default.
• W1822463313 cites W1991757117 @default.
• W1822463313 cites W1995920800 @default.
• W1822463313 cites W1999582975 @default.
• W1822463313 cites W2001178238 @default.
• W1822463313 cites W2026122699 @default.
• W1822463313 cites W2027431501 @default.
• W1822463313 cites W2033761235 @default.
• W1822463313 cites W2047115666 @default.
• W1822463313 cites W2059492063 @default.
• W1822463313 cites W2060908198 @default.
• W1822463313 cites W2065464657 @default.
• W1822463313 cites W2078761761 @default.
• W1822463313 cites W2085346499 @default.
• W1822463313 cites W2095530186 @default.
• W1822463313 cites W2096419601 @default.
• W1822463313 cites W2096672814 @default.
• W1822463313 cites W2098002594 @default.
• W1822463313 cites W2103255742 @default.
• W1822463313 cites W2106904404 @default.
• W1822463313 cites W2117120512 @default.
• W1822463313 cites W2120755425 @default.
• W1822463313 cites W2124235514 @default.
• W1822463313 cites W2125684345 @default.
• W1822463313 cites W2130093747 @default.
• W1822463313 cites W2130669641 @default.
• W1822463313 cites W2131956233 @default.
• W1822463313 cites W2131998596 @default.
• W1822463313 cites W2138498369 @default.
• W1822463313 cites W2143389421 @default.
• W1822463313 cites W2147422161 @default.
• W1822463313 cites W2154066874 @default.
• W1822463313 cites W2155713523 @default.
• W1822463313 cites W2156235279 @default.
• W1822463313 cites W2162109567 @default.
• W1822463313 cites W2166319122 @default.
• W1822463313 cites W2169209759 @default.
• W1822463313 cites W2171771895 @default.
• W1822463313 cites W2342982835 @default.
• W1822463313 cites W2408033184 @default.
• W1822463313 cites W2465051620 @default.
• W1822463313 cites W2473202055 @default.
• W1822463313 cites W2552559161 @default.
• W1822463313 cites W2556453873 @default.
• W1822463313 cites W2562559362 @default.
• W1822463313 cites W2582857650 @default.
• W1822463313 cites W2593436874 @default.
• W1822463313 cites W4205736005 @default.
• W1822463313 cites W4242167328 @default.
• W1822463313 doi "https://doi.org/10.1007/978-3-319-13150-4_10" @default.
• W1822463313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25655613" @default.
• W1822463313 hasPublicationYear "2015" @default.
• W1822463313 type Work @default.
• W1822463313 sameAs 1822463313 @default.
• W1822463313 citedByCount "9" @default.
• W1822463313 countsByYear W18224633132016 @default.
• W1822463313 countsByYear W18224633132017 @default.
• W1822463313 countsByYear W18224633132018 @default.
• W1822463313 countsByYear W18224633132019 @default.
• W1822463313 countsByYear W18224633132021 @default.
• W1822463313 countsByYear W18224633132022 @default.
• W1822463313 countsByYear W18224633132023 @default.
• W1822463313 crossrefType "book-chapter" @default.
• W1822463313 hasAuthorship W1822463313A5024389256 @default.
• W1822463313 hasAuthorship W1822463313A5056946123 @default.
• W1822463313 hasConcept C126322002 @default.
• W1822463313 hasConcept C141071460 @default.
• W1822463313 hasConcept C143998085 @default.
• W1822463313 hasConcept C2776063141 @default.
• W1822463313 hasConcept C2776364478 @default.
• W1822463313 hasConcept C2777478702 @default.
• W1822463313 hasConcept C2777525834 @default.
• W1822463313 hasConcept C2777938653 @default.
• W1822463313 hasConcept C2778461978 @default.
• W1822463313 hasConcept C2779050716 @default.
• W1822463313 hasConcept C2779338263 @default.
• W1822463313 hasConcept C2779878957 @default.
• W1822463313 hasConcept C2780653079 @default.
• W1822463313 hasConcept C2780790343 @default.
• W1822463313 hasConcept C2908647359 @default.
• W1822463313 hasConcept C71924100 @default.
• W1822463313 hasConcept C99454951 @default.
• W1822463313 hasConceptScore W1822463313C126322002 @default.
• W1822463313 hasConceptScore W1822463313C141071460 @default.
• W1822463313 hasConceptScore W1822463313C143998085 @default.
• W1822463313 hasConceptScore W1822463313C2776063141 @default.
• W1822463313 hasConceptScore W1822463313C2776364478 @default.
• W1822463313 hasConceptScore W1822463313C2777478702 @default.

• next