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• W182264404 abstract "Pleated membrane cartridge filters are used extensively throughout a typicalbioprocess. They are exposed to a range of operating conditions and feedstocks.Discrepancies between the performance of the flat sheet membrane and pleatedmembrane have previously been identified, although little has been done to fullycharacterise the effects of pleating. As current scale-up techniques use the flatsheet membrane to predict the performance of the large-scale pleated cartridge,the discrepancy in performance between flat sheet and pleated cartridge leads toinaccuracy in scale-up. This inaccuracy is accounted for by over-sizing of theequipment. In turn this reduces the efficiency of the bioprocess and increasescapital costs. At the present time no accurate and reliable scale-up methodologyexists that accounts for the effects of pleating.A systematic investigation into the effect of pleating has been conducted. Byvarying the key pleat characteristics: pleat height, type and packing density, theimpact upon cartridge performance of these characteristics has been determined.Using this knowledge, new scale-down cartridge filters have been developed,fabricated and tested. When faced with both clean water and a pepsin proteinsolution, performance was within 10% of the large-scale 10” counterpart, whilstoperating with a 1000 fold reduction in feed volume. This compares well to flatsheet membrane which showed up to 53% variation in performance to the pleatedcartridge filter.The scale-down cartridge is limited to the degree in which reduction of feedstockcan be achieved. So as to reduce feed volume requirements further, a ultra scaledownmethodology has been developed that uses experimental models to accountfor the effect that pleating has upon cartridge performance. When coupled withexperimental data derived from flat sheet discs, the scale-up performanceimproves predictions with flat sheet membrane however discrepancies still existbetween the two scales, suggesting that the method is not yet robust. Based upon the work of this thesis the close performance between the scaledowncartridges and the large-scale cartridges, coupled with the low feedrequirement, make the device an excellent method by which rapid scale-up canbe achieved during the process development of biopharmaceutical products.However, it is recommended that the ultra scale-down approach is developedfurther, so as to build a robust method to predict the performance of industrialscale pleated filter cartridges using significantly reduced areas of flat sheetmembrane." @default.
• W182264404 created "2016-06-24" @default.
• W182264404 creator A5019753348 @default.
• W182264404 date "2011-01-28" @default.
• W182264404 modified "2023-09-23" @default.
• W182264404 title "An ultra scale-down approach to the rapid evaluation of pleated membrane cartridge filter performance" @default.
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