FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1822736719> ?p ?o ?g. }

• W1822736719 endingPage "9" @default.
• W1822736719 startingPage "194" @default.
• W1822736719 abstract "CYP2D16 is expressed at high levels in the zona reticularis (ZR) of guinea pig adrenal glands and contributes to adrenal metabolism of xenobiotics. Studies were done to evaluate the effects of age and gender on adrenal CYP2D16 expression and xenobiotic metabolism. In both male and female guinea pigs at 1, 7, 14, or 30 weeks of age, in situ hybridization and immunohistochemistry confirmed that CYP2D16 was highly localized to the ZR of the adrenal gland. The steroidogenic P450 isozyme, CYP17, by contrast, was expressed in both the zona fasciculata and ZR. The intensity of CYP2D16 staining was not age- or gender-dependent. However, the proportion of each adrenal gland comprised by ZR and thus expressing CYP2D16 increased with aging in both sexes and was greater in males than in females. The rates of metabolism of bufuralol, a CYP2D-selective substrate, by adrenal microsomal preparations generally correlated with the amount of ZR (and CYP2D16) in the gland. Thus, adrenal xenobiotic-metabolizing activities were greater in males than in females at all ages and increased with aging in males. However, the rates of bufuralol metabolism declined in sexually mature females (14 weeks) from the levels found in prepubertal females (7 weeks) and then increased markedly in retired breeders (30 weeks), suggesting an inhibitory effect of estrogens on enzyme activity. The results indicate that the age and gender differences in adrenal CYP2D16 content are largely determined by differences in the size of the ZR rather than the concentrations of CYP2D16 within cells of the ZR. However, adrenal xenobiotic-metabolizing activities in females seem to be further modulated by an inhibitory effect of estrogens." @default.
• W1822736719 created "2016-06-24" @default.
• W1822736719 creator A5002263742 @default.
• W1822736719 creator A5011642310 @default.
• W1822736719 creator A5031891304 @default.
• W1822736719 creator A5072068799 @default.
• W1822736719 date "2001-02-01" @default.
• W1822736719 modified "2023-09-23" @default.
• W1822736719 title "Maturational changes in CYP2D16 expression and xenobiotic metabolism in adrenal glands from male and female guinea pigs." @default.
• W1822736719 cites W10958590 @default.
• W1822736719 cites W1648138277 @default.
• W1822736719 cites W1949792042 @default.
• W1822736719 cites W1967304942 @default.
• W1822736719 cites W1969215912 @default.
• W1822736719 cites W1975388054 @default.
• W1822736719 cites W1992035496 @default.
• W1822736719 cites W2008661156 @default.
• W1822736719 cites W2009096269 @default.
• W1822736719 cites W2016684961 @default.
• W1822736719 cites W2017431020 @default.
• W1822736719 cites W2017924587 @default.
• W1822736719 cites W2018429582 @default.
• W1822736719 cites W2021248021 @default.
• W1822736719 cites W2021290181 @default.
• W1822736719 cites W2022382264 @default.
• W1822736719 cites W2036509589 @default.
• W1822736719 cites W2049181029 @default.
• W1822736719 cites W2052535074 @default.
• W1822736719 cites W2070325295 @default.
• W1822736719 cites W2072644588 @default.
• W1822736719 cites W2078080530 @default.
• W1822736719 cites W2080884748 @default.
• W1822736719 cites W2083636680 @default.
• W1822736719 cites W2093202242 @default.
• W1822736719 cites W2117816495 @default.
• W1822736719 cites W2141052359 @default.
• W1822736719 cites W2151802894 @default.
• W1822736719 cites W2408975517 @default.
• W1822736719 cites W2411444817 @default.
• W1822736719 cites W2428968841 @default.
• W1822736719 cites W2999510508 @default.
• W1822736719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11159811" @default.
• W1822736719 hasPublicationYear "2001" @default.
• W1822736719 type Work @default.
• W1822736719 sameAs 1822736719 @default.
• W1822736719 citedByCount "2" @default.
• W1822736719 countsByYear W18227367192016 @default.
• W1822736719 crossrefType "journal-article" @default.
• W1822736719 hasAuthorship W1822736719A5002263742 @default.
• W1822736719 hasAuthorship W1822736719A5011642310 @default.
• W1822736719 hasAuthorship W1822736719A5031891304 @default.
• W1822736719 hasAuthorship W1822736719A5072068799 @default.
• W1822736719 hasConcept C115448650 @default.
• W1822736719 hasConcept C119795356 @default.
• W1822736719 hasConcept C126322002 @default.
• W1822736719 hasConcept C134018914 @default.
• W1822736719 hasConcept C181199279 @default.
• W1822736719 hasConcept C2777784954 @default.
• W1822736719 hasConcept C2778736161 @default.
• W1822736719 hasConcept C2778815084 @default.
• W1822736719 hasConcept C2780178468 @default.
• W1822736719 hasConcept C2780694816 @default.
• W1822736719 hasConcept C2908929049 @default.
• W1822736719 hasConcept C526171541 @default.
• W1822736719 hasConcept C55493867 @default.
• W1822736719 hasConcept C62231903 @default.
• W1822736719 hasConcept C71924100 @default.
• W1822736719 hasConcept C84393581 @default.
• W1822736719 hasConcept C86803240 @default.
• W1822736719 hasConcept C87644729 @default.
• W1822736719 hasConcept C89311334 @default.
• W1822736719 hasConceptScore W1822736719C115448650 @default.
• W1822736719 hasConceptScore W1822736719C119795356 @default.
• W1822736719 hasConceptScore W1822736719C126322002 @default.
• W1822736719 hasConceptScore W1822736719C134018914 @default.
• W1822736719 hasConceptScore W1822736719C181199279 @default.
• W1822736719 hasConceptScore W1822736719C2777784954 @default.
• W1822736719 hasConceptScore W1822736719C2778736161 @default.
• W1822736719 hasConceptScore W1822736719C2778815084 @default.
• W1822736719 hasConceptScore W1822736719C2780178468 @default.
• W1822736719 hasConceptScore W1822736719C2780694816 @default.
• W1822736719 hasConceptScore W1822736719C2908929049 @default.
• W1822736719 hasConceptScore W1822736719C526171541 @default.
• W1822736719 hasConceptScore W1822736719C55493867 @default.
• W1822736719 hasConceptScore W1822736719C62231903 @default.
• W1822736719 hasConceptScore W1822736719C71924100 @default.
• W1822736719 hasConceptScore W1822736719C84393581 @default.
• W1822736719 hasConceptScore W1822736719C86803240 @default.
• W1822736719 hasConceptScore W1822736719C87644729 @default.
• W1822736719 hasConceptScore W1822736719C89311334 @default.
• W1822736719 hasIssue "2" @default.
• W1822736719 hasLocation W18227367191 @default.
• W1822736719 hasOpenAccess W1822736719 @default.
• W1822736719 hasPrimaryLocation W18227367191 @default.
• W1822736719 hasRelatedWork W10958590 @default.
• W1822736719 hasRelatedWork W1822736719 @default.
• W1822736719 hasRelatedWork W1963519745 @default.
• W1822736719 hasRelatedWork W2028300313 @default.

• next