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• W1823184461 abstract "Many biological or chemical agents when combined interact with each other and produce a synergistic response that cannot be predicted based on the single agent responses alone. However, depending on the postulated null hypothesis of non-interaction, one may end up in different interpretations of synergy. Two popular reference models for null hypothesis include the Bliss independence model and the Loewe additivity model, each of which is formulated from different perspectives. During the last century, there has been an intensive debate on the suitability of these synergy models, both of which are theoretically justified and also in practice supported by different schools of scientists. More than twenty years ago, there was a community effort to make a consensus on the terminology one should use when claiming synergy. The agreement was formulated at a conference held in Saariselkä, Finland in 1992, stating that one should use the terms Bliss synergy or Loewe synergy to avoid ambiguity in the underlying models. We review the theoretical relationships between these models and argue that one should combine the advantages of both models to provide a more consistent definition of synergy and antagonism." @default.
• W1823184461 created "2016-06-24" @default.
• W1823184461 creator A5016681267 @default.
• W1823184461 creator A5067760174 @default.
• W1823184461 creator A5083397767 @default.
• W1823184461 date "2015-09-01" @default.
• W1823184461 modified "2023-10-06" @default.
• W1823184461 title "What is synergy? The Saariselkä agreement revisited" @default.
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• W1823184461 doi "https://doi.org/10.3389/fphar.2015.00181" @default.
• W1823184461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4555011" @default.
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