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• W1823198322 startingPage "957" @default.
• W1823198322 abstract "Abstract A population of bacteria growing in a nonlimiting medium includes mutator bacteria and transient mutators defined as wild-type bacteria which, due to occasional transcription or translation errors, display a mutator phenotype. A semiquantitative theoretical analysis of the steady-state composition of an Escherichia coli population suggests that true strong genotypic mutators produce about 3 x 10(-3) of the single mutations arising in the population, while transient mutators produce at least 10% of the single mutations and more than 95% of the simultaneous double mutations. Numbers of mismatch repair proteins inherited by the offspring, proportions of lethal mutations and mortality rates are among the main parameters that influence the steady-state composition of the population. These results have implications for the experimental manipulation of mutation rates and the evolutionary fixation of frequent but nearly neutral mutations (e.g., synonymous codon substitutions)." @default.
• W1823198322 created "2016-06-24" @default.
• W1823198322 creator A5016135809 @default.
• W1823198322 date "1991-11-01" @default.
• W1823198322 modified "2023-10-12" @default.
• W1823198322 title "Transient mutators: a semiquantitative analysis of the influence of translation and transcription errors on mutation rates." @default.
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• W1823198322 doi "https://doi.org/10.1093/genetics/129.3.957" @default.
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