Matches in SemOpenAlex for { <https://semopenalex.org/work/W1823218897> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1823218897 endingPage "1232" @default.
- W1823218897 startingPage "1227" @default.
- W1823218897 abstract "Expression of the Epstein-Barr virus (EBV) BZLF1 gene in latently infected lymphocytes is sufficient to trigger the viral lytic cycle. As shown in the accompanying report (E. Flemington and S.H. Speck, J. Virol. 64:1217-1226, 1990), the promoter for the BZLF1 gene (Zp) contains two distinct types of elements (ZI and ZII [an AP-1-like domain]) which are responsive to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of the viral lytic cycle. Although Zp can be activated with TPA in an EBV-negative Burkitt's lymphoma cell line (Ramos), its activity is considerably lower than in EBV-positive cell lines which can be induced with TPA. Here we show that the protein product of the BZLF1 gene (ZEBRA) can transactivate its own promoter by a mechanism which involves direct binding to a region distinct from the ZI and ZII element. Moreover, we show that this region is composed of two distinct ZEBRA-binding-transactivation domains. Interestingly, these two domains are not homologous, and while one domain (ZIIIA) is similar to previously described ZEBRA-binding domains, the second (ZIIIB) is a higher-affinity site which bears no detectable homology to the consensus ZEBRA recognition sequence. We also show that transactivation is independent of the otherwise essential ZII domain, suggesting that ZEBRA binding may functionally replace or supercede the need for a functional ZII domain. This observation supports a model for activation of the lytic cycle whereby synthesis of a critical level of ZEBRA signals commitment to BZLF1 transcription and initiation of the lytic cascade." @default.
- W1823218897 created "2016-06-24" @default.
- W1823218897 creator A5002551784 @default.
- W1823218897 creator A5016561426 @default.
- W1823218897 date "1990-03-01" @default.
- W1823218897 modified "2023-10-10" @default.
- W1823218897 title "Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1" @default.
- W1823218897 cites W1513838543 @default.
- W1823218897 cites W1525526263 @default.
- W1823218897 cites W1532984977 @default.
- W1823218897 cites W1760923416 @default.
- W1823218897 cites W1768619516 @default.
- W1823218897 cites W1841083068 @default.
- W1823218897 cites W1910426815 @default.
- W1823218897 cites W1914672256 @default.
- W1823218897 cites W2052654618 @default.
- W1823218897 cites W2067663793 @default.
- W1823218897 cites W2070591676 @default.
- W1823218897 cites W2081135713 @default.
- W1823218897 cites W2123711411 @default.
- W1823218897 cites W2127791051 @default.
- W1823218897 cites W2144206181 @default.
- W1823218897 cites W2152827395 @default.
- W1823218897 cites W2167835886 @default.
- W1823218897 cites W229719265 @default.
- W1823218897 cites W2298027515 @default.
- W1823218897 doi "https://doi.org/10.1128/jvi.64.3.1227-1232.1990" @default.
- W1823218897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/249237" @default.
- W1823218897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2154606" @default.
- W1823218897 hasPublicationYear "1990" @default.
- W1823218897 type Work @default.
- W1823218897 sameAs 1823218897 @default.
- W1823218897 citedByCount "244" @default.
- W1823218897 countsByYear W18232188972012 @default.
- W1823218897 countsByYear W18232188972013 @default.
- W1823218897 countsByYear W18232188972014 @default.
- W1823218897 countsByYear W18232188972015 @default.
- W1823218897 countsByYear W18232188972016 @default.
- W1823218897 countsByYear W18232188972017 @default.
- W1823218897 countsByYear W18232188972018 @default.
- W1823218897 countsByYear W18232188972019 @default.
- W1823218897 countsByYear W18232188972020 @default.
- W1823218897 countsByYear W18232188972021 @default.
- W1823218897 countsByYear W18232188972022 @default.
- W1823218897 crossrefType "journal-article" @default.
- W1823218897 hasAuthorship W1823218897A5002551784 @default.
- W1823218897 hasAuthorship W1823218897A5016561426 @default.
- W1823218897 hasBestOaLocation W18232188971 @default.
- W1823218897 hasConcept C104317684 @default.
- W1823218897 hasConcept C1292079 @default.
- W1823218897 hasConcept C153911025 @default.
- W1823218897 hasConcept C165864922 @default.
- W1823218897 hasConcept C182615771 @default.
- W1823218897 hasConcept C2522874641 @default.
- W1823218897 hasConcept C2776409557 @default.
- W1823218897 hasConcept C2780727368 @default.
- W1823218897 hasConcept C2781295983 @default.
- W1823218897 hasConcept C54355233 @default.
- W1823218897 hasConcept C86339819 @default.
- W1823218897 hasConcept C86803240 @default.
- W1823218897 hasConcept C95444343 @default.
- W1823218897 hasConceptScore W1823218897C104317684 @default.
- W1823218897 hasConceptScore W1823218897C1292079 @default.
- W1823218897 hasConceptScore W1823218897C153911025 @default.
- W1823218897 hasConceptScore W1823218897C165864922 @default.
- W1823218897 hasConceptScore W1823218897C182615771 @default.
- W1823218897 hasConceptScore W1823218897C2522874641 @default.
- W1823218897 hasConceptScore W1823218897C2776409557 @default.
- W1823218897 hasConceptScore W1823218897C2780727368 @default.
- W1823218897 hasConceptScore W1823218897C2781295983 @default.
- W1823218897 hasConceptScore W1823218897C54355233 @default.
- W1823218897 hasConceptScore W1823218897C86339819 @default.
- W1823218897 hasConceptScore W1823218897C86803240 @default.
- W1823218897 hasConceptScore W1823218897C95444343 @default.
- W1823218897 hasIssue "3" @default.
- W1823218897 hasLocation W18232188971 @default.
- W1823218897 hasLocation W18232188972 @default.
- W1823218897 hasLocation W18232188973 @default.
- W1823218897 hasLocation W18232188974 @default.
- W1823218897 hasOpenAccess W1823218897 @default.
- W1823218897 hasPrimaryLocation W18232188971 @default.
- W1823218897 hasRelatedWork W1571009376 @default.
- W1823218897 hasRelatedWork W1763261403 @default.
- W1823218897 hasRelatedWork W1970886246 @default.
- W1823218897 hasRelatedWork W2084737819 @default.
- W1823218897 hasRelatedWork W2096500953 @default.
- W1823218897 hasRelatedWork W2103324672 @default.
- W1823218897 hasRelatedWork W2120280372 @default.
- W1823218897 hasRelatedWork W2120350608 @default.
- W1823218897 hasRelatedWork W2138633314 @default.
- W1823218897 hasRelatedWork W4206658595 @default.
- W1823218897 hasVolume "64" @default.
- W1823218897 isParatext "false" @default.
- W1823218897 isRetracted "false" @default.
- W1823218897 magId "1823218897" @default.
- W1823218897 workType "article" @default.