Matches in SemOpenAlex for { <https://semopenalex.org/work/W1823256975> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1823256975 endingPage "3525" @default.
- W1823256975 startingPage "3525" @default.
- W1823256975 abstract "Purpose: To compare the impact of interplay effect on 3D and 4D robustly optimized intensity‐modulated proton therapy (IMPT) plans to treat lung cancer. Methods: Two IMPT plans were created for 11 non‐small‐cell‐lung‐cancer cases with 6–14 mm spots. 3D robust optimization generated plans on average CTs with the internal gross tumor volume density overridden to deliver 66 CGyE in 33 fractions to the internal target volume (ITV). 4D robust optimization generated plans on 4D CTs with the delivery of prescribed dose to the clinical target volume (CTV). In 4D optimization, the CTV of individual 4D CT phases received non‐uniform doses to achieve a uniform cumulative dose. Dose evaluation software was developed to model time‐dependent spot delivery to incorporate interplay effect with randomized starting phases of each field per fraction. Patient anatomy voxels were mapped from phase to phase via deformable image registration to score doses. Indices from dose‐volume histograms were used to compare target coverage, dose homogeneity, and normal‐tissue sparing. DVH indices were compared using Wilcoxon test. Results: Given the presence of interplay effect, 4D robust optimization produced IMPT plans with better target coverage and homogeneity, but slightly worse normal tissue sparing compared to 3D robust optimization (unit: Gy) [D95% ITV: 63.5 vs 62.0 (p=0.014), D5% ‐ D95% ITV: 6.2 vs 7.3 (p=0.37), D1% spinal cord: 29.0 vs 29.5 (p=0.52), Dmean total lung: 14.8 vs 14.5 (p=0.12), D33% esophagus: 33.6 vs 33.1 (p=0.28)]. The improvement of target coverage (D95%,4D – D95%,3D) was related to the ratio RMA3/(TVx10−4), with RMA and TV being respiratory motion amplitude (RMA) and tumor volume (TV), respectively. Peak benefit was observed at ratios between 2 and 10. This corresponds to 125 – 625 cm3 TV with 0.5‐cm RMA. Conclusion: 4D optimization produced more interplay‐effect‐resistant plans compared to 3D optimization. It is most effective when respiratory motion is modest compared to TV. NIH/NCI K25CA168984; Eagles Cancer Research Career Development; The Lawrence W. and Marilyn W. Matteson Fund for Cancer Research; Mayo ASU Seed Grant; The Kemper Marley Foundation" @default.
- W1823256975 created "2016-06-24" @default.
- W1823256975 creator A5008781374 @default.
- W1823256975 creator A5018667251 @default.
- W1823256975 creator A5030089962 @default.
- W1823256975 creator A5032704742 @default.
- W1823256975 creator A5040972494 @default.
- W1823256975 creator A5041943880 @default.
- W1823256975 creator A5062660562 @default.
- W1823256975 creator A5062848479 @default.
- W1823256975 creator A5086483620 @default.
- W1823256975 creator A5086572064 @default.
- W1823256975 creator A5091679738 @default.
- W1823256975 creator A5024395359 @default.
- W1823256975 date "2015-06-01" @default.
- W1823256975 modified "2023-10-06" @default.
- W1823256975 title "SU-F-BRD-01: A Novel 4D Robust Optimization Mitigates Interplay Effect in Intensity-Modulated Proton Therapy for Lung Cancer" @default.
- W1823256975 doi "https://doi.org/10.1118/1.4925180" @default.
- W1823256975 hasPublicationYear "2015" @default.
- W1823256975 type Work @default.
- W1823256975 sameAs 1823256975 @default.
- W1823256975 citedByCount "2" @default.
- W1823256975 countsByYear W18232569752018 @default.
- W1823256975 countsByYear W18232569752019 @default.
- W1823256975 crossrefType "journal-article" @default.
- W1823256975 hasAuthorship W1823256975A5008781374 @default.
- W1823256975 hasAuthorship W1823256975A5018667251 @default.
- W1823256975 hasAuthorship W1823256975A5024395359 @default.
- W1823256975 hasAuthorship W1823256975A5030089962 @default.
- W1823256975 hasAuthorship W1823256975A5032704742 @default.
- W1823256975 hasAuthorship W1823256975A5040972494 @default.
- W1823256975 hasAuthorship W1823256975A5041943880 @default.
- W1823256975 hasAuthorship W1823256975A5062660562 @default.
- W1823256975 hasAuthorship W1823256975A5062848479 @default.
- W1823256975 hasAuthorship W1823256975A5086483620 @default.
- W1823256975 hasAuthorship W1823256975A5086572064 @default.
- W1823256975 hasAuthorship W1823256975A5091679738 @default.
- W1823256975 hasConcept C121332964 @default.
- W1823256975 hasConcept C126838900 @default.
- W1823256975 hasConcept C143998085 @default.
- W1823256975 hasConcept C2776256026 @default.
- W1823256975 hasConcept C2779244869 @default.
- W1823256975 hasConcept C2989005 @default.
- W1823256975 hasConcept C509974204 @default.
- W1823256975 hasConcept C54170458 @default.
- W1823256975 hasConcept C62520636 @default.
- W1823256975 hasConcept C71924100 @default.
- W1823256975 hasConcept C93038891 @default.
- W1823256975 hasConceptScore W1823256975C121332964 @default.
- W1823256975 hasConceptScore W1823256975C126838900 @default.
- W1823256975 hasConceptScore W1823256975C143998085 @default.
- W1823256975 hasConceptScore W1823256975C2776256026 @default.
- W1823256975 hasConceptScore W1823256975C2779244869 @default.
- W1823256975 hasConceptScore W1823256975C2989005 @default.
- W1823256975 hasConceptScore W1823256975C509974204 @default.
- W1823256975 hasConceptScore W1823256975C54170458 @default.
- W1823256975 hasConceptScore W1823256975C62520636 @default.
- W1823256975 hasConceptScore W1823256975C71924100 @default.
- W1823256975 hasConceptScore W1823256975C93038891 @default.
- W1823256975 hasIssue "6Part25" @default.
- W1823256975 hasLocation W18232569751 @default.
- W1823256975 hasOpenAccess W1823256975 @default.
- W1823256975 hasPrimaryLocation W18232569751 @default.
- W1823256975 hasRelatedWork W1998563493 @default.
- W1823256975 hasRelatedWork W2016533837 @default.
- W1823256975 hasRelatedWork W2082728368 @default.
- W1823256975 hasRelatedWork W2892386716 @default.
- W1823256975 hasRelatedWork W3027020613 @default.
- W1823256975 hasRelatedWork W3035904869 @default.
- W1823256975 hasRelatedWork W3167885074 @default.
- W1823256975 hasRelatedWork W4306164210 @default.
- W1823256975 hasRelatedWork W4313316311 @default.
- W1823256975 hasRelatedWork W4362608745 @default.
- W1823256975 hasVolume "42" @default.
- W1823256975 isParatext "false" @default.
- W1823256975 isRetracted "false" @default.
- W1823256975 magId "1823256975" @default.
- W1823256975 workType "article" @default.