FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1823273132> ?p ?o ?g. }

• W1823273132 endingPage "188" @default.
• W1823273132 startingPage "182" @default.
• W1823273132 abstract "Abstract Both CD28 and ICOS are important costimulatory molecules that promote Ag-specific cellular and humoral immune reactions. Whereas CD28 is generally thought to be the most important molecule in the initiation of a T cell response, ICOS is considered to act during the effector phase. We have investigated the contribution of ICOS to T cell responses in the absence of CTLA-4-mediated inhibition. Mice lacking CTLA-4, which show spontaneous CD28-mediated CD4+ T cell activation, expansion and differentiation, were treated with antagonistic αICOS antibodies. Blocking the interaction between ICOS and its ligand B7RP-1 significantly reduced this aberrant T cell activation and caused a reduction in T cell numbers. In vitro analysis of CD4+ T cells from treated mice revealed that ICOS blockade significantly reduced Th1 differentiation, while Th2 differentiation was only moderately inhibited. Further in vitro stimulation experiments demonstrated that ICOS is able to induce proliferation of murine CD4+ and CD8+ T cells but only in the presence of IL-2. These results indicate that ICOS is not only important for T cell effector function but also contributes to the expansion phase of a T cell response in the presence of CD28 signaling." @default.
• W1823273132 created "2016-06-24" @default.
• W1823273132 creator A5026356960 @default.
• W1823273132 creator A5037034997 @default.
• W1823273132 creator A5041573634 @default.
• W1823273132 creator A5044052948 @default.
• W1823273132 creator A5046387415 @default.
• W1823273132 creator A5051969821 @default.
• W1823273132 creator A5064419311 @default.
• W1823273132 creator A5086893207 @default.
• W1823273132 date "2005-07-01" @default.
• W1823273132 modified "2023-10-14" @default.
• W1823273132 title "ICOS Contributes to T Cell Expansion in CTLA-4 Deficient Mice" @default.
• W1823273132 cites W118130514 @default.
• W1823273132 cites W1482629150 @default.
• W1823273132 cites W1488633968 @default.
• W1823273132 cites W1489480103 @default.
• W1823273132 cites W1515237957 @default.
• W1823273132 cites W1516026495 @default.
• W1823273132 cites W1534774246 @default.
• W1823273132 cites W1542262758 @default.
• W1823273132 cites W1548331405 @default.
• W1823273132 cites W1564765245 @default.
• W1823273132 cites W1581138690 @default.
• W1823273132 cites W1626388077 @default.
• W1823273132 cites W1661441964 @default.
• W1823273132 cites W1667545291 @default.
• W1823273132 cites W1810174285 @default.
• W1823273132 cites W1855741677 @default.
• W1823273132 cites W1898621392 @default.
• W1823273132 cites W1918304741 @default.
• W1823273132 cites W1978373343 @default.
• W1823273132 cites W1983626365 @default.
• W1823273132 cites W2020346226 @default.
• W1823273132 cites W2026893575 @default.
• W1823273132 cites W2041076028 @default.
• W1823273132 cites W2041980736 @default.
• W1823273132 cites W2043007190 @default.
• W1823273132 cites W2057903858 @default.
• W1823273132 cites W2076067786 @default.
• W1823273132 cites W2087850260 @default.
• W1823273132 cites W2090481553 @default.
• W1823273132 cites W2091783976 @default.
• W1823273132 cites W2093542451 @default.
• W1823273132 cites W2094515886 @default.
• W1823273132 cites W2107473879 @default.
• W1823273132 cites W2118175246 @default.
• W1823273132 cites W2123631710 @default.
• W1823273132 cites W2128810183 @default.
• W1823273132 cites W2140066663 @default.
• W1823273132 cites W2144420689 @default.
• W1823273132 cites W2149288393 @default.
• W1823273132 cites W2162380170 @default.
• W1823273132 cites W2171026458 @default.
• W1823273132 cites W2886274086 @default.
• W1823273132 cites W4250851417 @default.
• W1823273132 doi "https://doi.org/10.4049/jimmunol.175.1.182" @default.
• W1823273132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15972646" @default.
• W1823273132 hasPublicationYear "2005" @default.
• W1823273132 type Work @default.
• W1823273132 sameAs 1823273132 @default.
• W1823273132 citedByCount "14" @default.
• W1823273132 countsByYear W18232731322012 @default.
• W1823273132 countsByYear W18232731322013 @default.
• W1823273132 countsByYear W18232731322014 @default.
• W1823273132 countsByYear W18232731322018 @default.
• W1823273132 countsByYear W18232731322019 @default.
• W1823273132 crossrefType "journal-article" @default.
• W1823273132 hasAuthorship W1823273132A5026356960 @default.
• W1823273132 hasAuthorship W1823273132A5037034997 @default.
• W1823273132 hasAuthorship W1823273132A5041573634 @default.
• W1823273132 hasAuthorship W1823273132A5044052948 @default.
• W1823273132 hasAuthorship W1823273132A5046387415 @default.
• W1823273132 hasAuthorship W1823273132A5051969821 @default.
• W1823273132 hasAuthorship W1823273132A5064419311 @default.
• W1823273132 hasAuthorship W1823273132A5086893207 @default.
• W1823273132 hasBestOaLocation W18232731321 @default.
• W1823273132 hasConcept C134018914 @default.
• W1823273132 hasConcept C148125776 @default.
• W1823273132 hasConcept C154317977 @default.
• W1823273132 hasConcept C167672396 @default.
• W1823273132 hasConcept C185592680 @default.
• W1823273132 hasConcept C202751555 @default.
• W1823273132 hasConcept C203014093 @default.
• W1823273132 hasConcept C21705690 @default.
• W1823273132 hasConcept C24998067 @default.
• W1823273132 hasConcept C2776090121 @default.
• W1823273132 hasConcept C2780405999 @default.
• W1823273132 hasConcept C51785407 @default.
• W1823273132 hasConcept C55493867 @default.
• W1823273132 hasConcept C86803240 @default.
• W1823273132 hasConcept C8891405 @default.
• W1823273132 hasConcept C95444343 @default.
• W1823273132 hasConceptScore W1823273132C134018914 @default.
• W1823273132 hasConceptScore W1823273132C148125776 @default.
• W1823273132 hasConceptScore W1823273132C154317977 @default.
• W1823273132 hasConceptScore W1823273132C167672396 @default.
• W1823273132 hasConceptScore W1823273132C185592680 @default.

• next