FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1823373572> ?p ?o ?g. }

• W1823373572 endingPage "1846" @default.
• W1823373572 startingPage "1836" @default.
• W1823373572 abstract "Long-circulating gold nanoparticles (AuNPs) have garnered a great deal of interest as both imaging and therapeutic agents. However, their protracted elimination and long-term persistence within many organ systems remains a concern for clinical translation. To improve the excretion of long-circulating nanoparticles, we prepared -80 nm biodegradable polymeric micelles with 0.9 nm or 5 nm AuNPs tightly packed within the hydrophobic core. These gold-loaded polymeric micelles (GPMs) were expected to allow for improved excretion of gold, compared with single large AuNPs, owing to the smaller size and larger surface-to-volume ratio of the individual AuNPs within the micelle. Following intravenous administration of GPMs, organs were harvested and examined for gold content using inductively coupled plasma optical emission spectrometry (ICP-OES) for up to 3 months post-injection. While both GPM formulations showed significant clearance of gold over time, micelles containing 0.9 nm AuNPs showed a 72% and 67% reduction in gold content in the liver and spleen, respectively, between 1 day and 3 months post-injection, compared with a 38% and 35% reduction in mice receiving 5 nm GPMs. Furthermore, feces and urine analysis revealed approximately 7.5 and 100 times more gold, respectively, in mice that received 0.9 nm GPMs one day after injection. These findings suggest that the excretion profile of inorganic nanomaterials may be improved if clusters of small inorganic materials are used in favor of single solid particles." @default.
• W1823373572 created "2016-06-24" @default.
• W1823373572 creator A5025421643 @default.
• W1823373572 creator A5027596223 @default.
• W1823373572 creator A5050848198 @default.
• W1823373572 creator A5078510726 @default.
• W1823373572 date "2015-10-01" @default.
• W1823373572 modified "2023-09-25" @default.
• W1823373572 title "Biodistribution, Clearance, and Toxicology of Polymeric Micelles Loaded with 0.9 or 5 nm Gold Nanoparticles" @default.
• W1823373572 cites W1505560697 @default.
• W1823373572 cites W1967043259 @default.
• W1823373572 cites W1968403075 @default.
• W1823373572 cites W1980802703 @default.
• W1823373572 cites W1981638413 @default.
• W1823373572 cites W2001846107 @default.
• W1823373572 cites W2014008281 @default.
• W1823373572 cites W2015406961 @default.
• W1823373572 cites W2020538451 @default.
• W1823373572 cites W2024598687 @default.
• W1823373572 cites W2026494961 @default.
• W1823373572 cites W2040332674 @default.
• W1823373572 cites W2044794349 @default.
• W1823373572 cites W2049711982 @default.
• W1823373572 cites W2054992180 @default.
• W1823373572 cites W2059999322 @default.
• W1823373572 cites W2063318887 @default.
• W1823373572 cites W2088137430 @default.
• W1823373572 cites W2089915138 @default.
• W1823373572 cites W2092877053 @default.
• W1823373572 cites W2098441675 @default.
• W1823373572 cites W2106600662 @default.
• W1823373572 cites W2116810900 @default.
• W1823373572 cites W2119591285 @default.
• W1823373572 cites W2121170935 @default.
• W1823373572 cites W2125430310 @default.
• W1823373572 cites W2125753084 @default.
• W1823373572 cites W2129191745 @default.
• W1823373572 cites W2137335948 @default.
• W1823373572 cites W2137374477 @default.
• W1823373572 cites W2145921425 @default.
• W1823373572 cites W2168113028 @default.
• W1823373572 cites W277569163 @default.
• W1823373572 doi "https://doi.org/10.1166/jbn.2015.2142" @default.
• W1823373572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4942304" @default.
• W1823373572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26502646" @default.
• W1823373572 hasPublicationYear "2015" @default.
• W1823373572 type Work @default.
• W1823373572 sameAs 1823373572 @default.
• W1823373572 citedByCount "37" @default.
• W1823373572 countsByYear W18233735722016 @default.
• W1823373572 countsByYear W18233735722017 @default.
• W1823373572 countsByYear W18233735722018 @default.
• W1823373572 countsByYear W18233735722019 @default.
• W1823373572 countsByYear W18233735722020 @default.
• W1823373572 countsByYear W18233735722021 @default.
• W1823373572 countsByYear W18233735722022 @default.
• W1823373572 countsByYear W18233735722023 @default.
• W1823373572 crossrefType "journal-article" @default.
• W1823373572 hasAuthorship W1823373572A5025421643 @default.
• W1823373572 hasAuthorship W1823373572A5027596223 @default.
• W1823373572 hasAuthorship W1823373572A5050848198 @default.
• W1823373572 hasAuthorship W1823373572A5078510726 @default.
• W1823373572 hasBestOaLocation W18233735722 @default.
• W1823373572 hasConcept C10146269 @default.
• W1823373572 hasConcept C104819515 @default.
• W1823373572 hasConcept C11268172 @default.
• W1823373572 hasConcept C138631740 @default.
• W1823373572 hasConcept C13965031 @default.
• W1823373572 hasConcept C155672457 @default.
• W1823373572 hasConcept C171250308 @default.
• W1823373572 hasConcept C178790620 @default.
• W1823373572 hasConcept C184651966 @default.
• W1823373572 hasConcept C185592680 @default.
• W1823373572 hasConcept C192562407 @default.
• W1823373572 hasConcept C202751555 @default.
• W1823373572 hasConcept C2777807558 @default.
• W1823373572 hasConcept C55493867 @default.
• W1823373572 hasConceptScore W1823373572C10146269 @default.
• W1823373572 hasConceptScore W1823373572C104819515 @default.
• W1823373572 hasConceptScore W1823373572C11268172 @default.
• W1823373572 hasConceptScore W1823373572C138631740 @default.
• W1823373572 hasConceptScore W1823373572C13965031 @default.
• W1823373572 hasConceptScore W1823373572C155672457 @default.
• W1823373572 hasConceptScore W1823373572C171250308 @default.
• W1823373572 hasConceptScore W1823373572C178790620 @default.
• W1823373572 hasConceptScore W1823373572C184651966 @default.
• W1823373572 hasConceptScore W1823373572C185592680 @default.
• W1823373572 hasConceptScore W1823373572C192562407 @default.
• W1823373572 hasConceptScore W1823373572C202751555 @default.
• W1823373572 hasConceptScore W1823373572C2777807558 @default.
• W1823373572 hasConceptScore W1823373572C55493867 @default.
• W1823373572 hasIssue "10" @default.
• W1823373572 hasLocation W18233735721 @default.
• W1823373572 hasLocation W18233735722 @default.
• W1823373572 hasLocation W18233735723 @default.
• W1823373572 hasLocation W18233735724 @default.
• W1823373572 hasOpenAccess W1823373572 @default.
• W1823373572 hasPrimaryLocation W18233735721 @default.

• next