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• W1823419985 abstract "To compare an ovarian stimulation protocol using microdose follicular phase GnRH agonist (GnRH-a) and oral contraceptive (OC) pills to a luteal phase GnRH-a protocol.Retrospective analysis.University affiliated IVF program.One hundred seventy patients who underwent IVF and ET in 1996.Patients were assigned to either a midluteal start of leuprolide acetate (LA) 1 mg/d, reduced to 0.5 mg/d after addition of gonadotropins (LUT), or OC pills until cycle day 0 followed by 20 microg of LA every 12 hours on cycle day 3 with addition of gonadotropins on cycle day 5 (MICRO).Number of FSH ampules, days of stimulation, peak E2, and number of oocytes retrieved.There were no statistically significant differences in the main outcome measures between the two groups using an age-matched ANOVA. Clinical pregnancy rate per cycle start was not statistically different (LUT = 54%, and MICRO = 37%). The cancellation rate was significantly higher in the MICRO group (22.5% vs. 8.2%).Given the higher cancellation rate in the microdose group, a randomized clinical trial is required to determine the possible benefit of a lower dose of GnRH-a in patients with normal ovarian function." @default.
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• W1823419985 date "1999-12-01" @default.
• W1823419985 modified "2023-10-01" @default.
• W1823419985 title "Microdose follicular phase gonadotropin-releasing hormone agonists (GnRH-a) compared with luteal phase GnRH-a for ovarian stimulation at in vitro fertilization" @default.
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• W1823419985 doi "https://doi.org/10.1016/s0015-0282(99)00423-9" @default.
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