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• W1823949699 abstract "Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder that is associated with paraneoplastic diseases. Because OMS can frequently relapse, patients may be inflicted with neurological problems for a long time. Recently, rituximab (RTX) was introduced as a drug to treat OMS. To assess RTX treatment, we studied a patient who experienced recurrence of OMS.A 2-year-old Japanese boy, who had left adrenal neuroblastoma, suddenly showed OMS symptoms, including ataxia and opsoclonus. Surgical resection of the tumor and subsequent steroid therapy ameliorated his symptoms. When OMS relapsed during the time when prednisolone was reduced, he was treated with full-dose RTX therapy (375 mg/m2/week) for 4 consecutive weeks. However, 1year later, he presented again with OMS symptoms. This time, we only administered an additional single dose of RTX treatment (375 mg/m2), allowing remission of OMS symptoms. During 2 years after the additional RTX treatment, OMS symptoms did not appear, even when prednisolone was reduced. He had no adverse events associated with RTX during the whole treatment period.An additional single-dose RTX therapy might be effective for relapsed OMS patients who were previously treated with full-dose RTX therapy." @default.
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• W1823949699 date "2016-03-01" @default.
• W1823949699 modified "2023-10-02" @default.
• W1823949699 title "Rituximab treatment for relapsed opsoclonus–myoclonus syndrome" @default.
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• W1823949699 doi "https://doi.org/10.1016/j.braindev.2015.09.002" @default.
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