Matches in SemOpenAlex for { <https://semopenalex.org/work/W1824106222> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1824106222 abstract "The Komeda miniature rat Ishikawa (KMI) is a spontaneous animal model of dwarfism caused by a mutation in Prkg2, which encodes cGMP-dependent protein kinase type II (cGKII). This strain has been maintained as a segregating inbred strain for the mutated allele mri. In this study, we characterized the phenotype of the KMI strain, particularly growth traits, craniofacial measurements, and organ weights. The homozygous mutant (mri/mri) animals were approximately 70% to 80% of the size of normal, heterozygous (mri/+) animals in regard to body length, weight, and naso-occipital length of the calvarium, and the retroperitoneal fat of mri/mri rats was reduced greatly. In addition, among progeny of the (BNxKMI-mri/mri)F1xKMI-mri/mri backcross, animals with the KMI phenotype (mri/mri) were easily distinguished from those showing the wild-type phenotype (mri/+) by using growth traits such as body length and weight. Genetic analysis revealed that all of the backcrossed progeny exhibiting the KMI phenotype were homozygous for the KMI allele in the 1.2-cM region between D14Rat5 and D14Rat80 on chromosome 14, suggesting strongly that mri acts in a completely recessive manner. The KMI strain is the first and only rat model with a confirmed mutation in Prkg2 and is a valuable model for studying dwarfism and longitudinal growth traits in humans and for functional studies of cGKII." @default.
- W1824106222 created "2016-06-24" @default.
- W1824106222 creator A5001168434 @default.
- W1824106222 creator A5005366101 @default.
- W1824106222 creator A5063928607 @default.
- W1824106222 creator A5064956280 @default.
- W1824106222 creator A5065958668 @default.
- W1824106222 creator A5069598242 @default.
- W1824106222 creator A5075253797 @default.
- W1824106222 creator A5090475375 @default.
- W1824106222 date "2008-12-01" @default.
- W1824106222 modified "2023-09-23" @default.
- W1824106222 title "Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2." @default.
- W1824106222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2710756" @default.
- W1824106222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19149413" @default.
- W1824106222 hasPublicationYear "2008" @default.
- W1824106222 type Work @default.
- W1824106222 sameAs 1824106222 @default.
- W1824106222 citedByCount "5" @default.
- W1824106222 countsByYear W18241062222015 @default.
- W1824106222 countsByYear W18241062222019 @default.
- W1824106222 countsByYear W18241062222021 @default.
- W1824106222 crossrefType "journal-article" @default.
- W1824106222 hasAuthorship W1824106222A5001168434 @default.
- W1824106222 hasAuthorship W1824106222A5005366101 @default.
- W1824106222 hasAuthorship W1824106222A5063928607 @default.
- W1824106222 hasAuthorship W1824106222A5064956280 @default.
- W1824106222 hasAuthorship W1824106222A5065958668 @default.
- W1824106222 hasAuthorship W1824106222A5069598242 @default.
- W1824106222 hasAuthorship W1824106222A5075253797 @default.
- W1824106222 hasAuthorship W1824106222A5090475375 @default.
- W1824106222 hasConcept C104317684 @default.
- W1824106222 hasConcept C126322002 @default.
- W1824106222 hasConcept C127716648 @default.
- W1824106222 hasConcept C134018914 @default.
- W1824106222 hasConcept C143065580 @default.
- W1824106222 hasConcept C180754005 @default.
- W1824106222 hasConcept C2778111144 @default.
- W1824106222 hasConcept C2778117688 @default.
- W1824106222 hasConcept C501734568 @default.
- W1824106222 hasConcept C54355233 @default.
- W1824106222 hasConcept C71924100 @default.
- W1824106222 hasConcept C72472911 @default.
- W1824106222 hasConcept C86803240 @default.
- W1824106222 hasConceptScore W1824106222C104317684 @default.
- W1824106222 hasConceptScore W1824106222C126322002 @default.
- W1824106222 hasConceptScore W1824106222C127716648 @default.
- W1824106222 hasConceptScore W1824106222C134018914 @default.
- W1824106222 hasConceptScore W1824106222C143065580 @default.
- W1824106222 hasConceptScore W1824106222C180754005 @default.
- W1824106222 hasConceptScore W1824106222C2778111144 @default.
- W1824106222 hasConceptScore W1824106222C2778117688 @default.
- W1824106222 hasConceptScore W1824106222C501734568 @default.
- W1824106222 hasConceptScore W1824106222C54355233 @default.
- W1824106222 hasConceptScore W1824106222C71924100 @default.
- W1824106222 hasConceptScore W1824106222C72472911 @default.
- W1824106222 hasConceptScore W1824106222C86803240 @default.
- W1824106222 hasLocation W18241062221 @default.
- W1824106222 hasOpenAccess W1824106222 @default.
- W1824106222 hasPrimaryLocation W18241062221 @default.
- W1824106222 hasRelatedWork W1715578478 @default.
- W1824106222 hasRelatedWork W1795315950 @default.
- W1824106222 hasRelatedWork W1971916225 @default.
- W1824106222 hasRelatedWork W1972028273 @default.
- W1824106222 hasRelatedWork W1975748795 @default.
- W1824106222 hasRelatedWork W1976535279 @default.
- W1824106222 hasRelatedWork W1977531566 @default.
- W1824106222 hasRelatedWork W2001030163 @default.
- W1824106222 hasRelatedWork W2023958098 @default.
- W1824106222 hasRelatedWork W2061505810 @default.
- W1824106222 hasRelatedWork W2075612080 @default.
- W1824106222 hasRelatedWork W2080927041 @default.
- W1824106222 hasRelatedWork W2099336800 @default.
- W1824106222 hasRelatedWork W2101237598 @default.
- W1824106222 hasRelatedWork W2113221959 @default.
- W1824106222 hasRelatedWork W2132875532 @default.
- W1824106222 hasRelatedWork W2134331049 @default.
- W1824106222 hasRelatedWork W2150514160 @default.
- W1824106222 hasRelatedWork W2152357897 @default.
- W1824106222 hasRelatedWork W164948817 @default.
- W1824106222 isParatext "false" @default.
- W1824106222 isRetracted "false" @default.
- W1824106222 magId "1824106222" @default.
- W1824106222 workType "article" @default.