FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1824130715> ?p ?o ?g. }

• W1824130715 endingPage "1741" @default.
• W1824130715 startingPage "1730" @default.
• W1824130715 abstract "Mutation of Arabidopsis thaliana NAD(P)H DEHYDROGENASE C1 (NDC1; At5g08740) results in the accumulation of demethylphylloquinone, a late biosynthetic intermediate of vitamin K1. Gene coexpression and phylogenomics analyses showed that conserved functional associations occur between vitamin K biosynthesis and NDC1 homologs throughout the prokaryotic and eukaryotic lineages. Deletion of Synechocystis ndbB, which encodes for one such homolog, resulted in the same defects as those observed in the cyanobacterial demethylnaphthoquinone methyltransferase knockout. Chemical modeling and assay of purified demethylnaphthoquinone methyltransferase demonstrated that, by virtue of the strong electrophilic nature of S-adenosyl-l-methionine, the transmethylation of the demethylated precursor of vitamin K is strictly dependent on the reduced form of its naphthoquinone ring. NDC1 was shown to catalyze such a prerequisite reduction by using NADPH and demethylphylloquinone as substrates and flavine adenine dinucleotide as a cofactor. NDC1 displayed Michaelis-Menten kinetics and was markedly inhibited by dicumarol, a competitive inhibitor of naphthoquinone oxidoreductases. These data demonstrate that the reduction of the demethylnaphthoquinone ring represents an authentic step in the biosynthetic pathway of vitamin K, that this reaction is enzymatically driven, and that a selection pressure is operating to retain type II NAD(P)H dehydrogenases in this process." @default.
• W1824130715 created "2016-06-24" @default.
• W1824130715 creator A5014328287 @default.
• W1824130715 creator A5015533161 @default.
• W1824130715 creator A5041915207 @default.
• W1824130715 creator A5044335396 @default.
• W1824130715 creator A5046201736 @default.
• W1824130715 creator A5049664359 @default.
• W1824130715 creator A5052051439 @default.
• W1824130715 creator A5057314490 @default.
• W1824130715 date "2015-05-28" @default.
• W1824130715 modified "2023-10-14" @default.
• W1824130715 title "A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in S<i>ynechocystis</i> and Arabidopsis" @default.
• W1824130715 cites W117249372 @default.
• W1824130715 cites W1521650410 @default.
• W1824130715 cites W1546472725 @default.
• W1824130715 cites W1566824418 @default.
• W1824130715 cites W1584307670 @default.
• W1824130715 cites W1606063587 @default.
• W1824130715 cites W1900863447 @default.
• W1824130715 cites W1944328955 @default.
• W1824130715 cites W1946933859 @default.
• W1824130715 cites W1963957860 @default.
• W1824130715 cites W1965064481 @default.
• W1824130715 cites W1977047136 @default.
• W1824130715 cites W1977052943 @default.
• W1824130715 cites W1977659002 @default.
• W1824130715 cites W1980516267 @default.
• W1824130715 cites W2002188322 @default.
• W1824130715 cites W2009471543 @default.
• W1824130715 cites W2013207977 @default.
• W1824130715 cites W2023741270 @default.
• W1824130715 cites W2036330617 @default.
• W1824130715 cites W2039694742 @default.
• W1824130715 cites W2041519537 @default.
• W1824130715 cites W2047056233 @default.
• W1824130715 cites W2055155526 @default.
• W1824130715 cites W2055211670 @default.
• W1824130715 cites W2075124721 @default.
• W1824130715 cites W2087809116 @default.
• W1824130715 cites W2105924489 @default.
• W1824130715 cites W2106936402 @default.
• W1824130715 cites W2107556774 @default.
• W1824130715 cites W2107865271 @default.
• W1824130715 cites W2111211467 @default.
• W1824130715 cites W2114005417 @default.
• W1824130715 cites W2115823159 @default.
• W1824130715 cites W2121152339 @default.
• W1824130715 cites W2123009444 @default.
• W1824130715 cites W2126079531 @default.
• W1824130715 cites W2127168738 @default.
• W1824130715 cites W2128635872 @default.
• W1824130715 cites W2130429520 @default.
• W1824130715 cites W2130934749 @default.
• W1824130715 cites W2132319447 @default.
• W1824130715 cites W2132926880 @default.
• W1824130715 cites W2138289193 @default.
• W1824130715 cites W2142283539 @default.
• W1824130715 cites W2145657287 @default.
• W1824130715 cites W2153629132 @default.
• W1824130715 cites W2158187542 @default.
• W1824130715 cites W2161093145 @default.
• W1824130715 cites W2171732491 @default.
• W1824130715 cites W4293247451 @default.
• W1824130715 cites W58462173 @default.
• W1824130715 cites W88823854 @default.
• W1824130715 doi "https://doi.org/10.1105/tpc.15.00103" @default.
• W1824130715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4498204" @default.
• W1824130715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26023160" @default.
• W1824130715 hasPublicationYear "2015" @default.
• W1824130715 type Work @default.
• W1824130715 sameAs 1824130715 @default.
• W1824130715 citedByCount "50" @default.
• W1824130715 countsByYear W18241307152015 @default.
• W1824130715 countsByYear W18241307152016 @default.
• W1824130715 countsByYear W18241307152017 @default.
• W1824130715 countsByYear W18241307152018 @default.
• W1824130715 countsByYear W18241307152019 @default.
• W1824130715 countsByYear W18241307152020 @default.
• W1824130715 countsByYear W18241307152021 @default.
• W1824130715 countsByYear W18241307152022 @default.
• W1824130715 countsByYear W18241307152023 @default.
• W1824130715 crossrefType "journal-article" @default.
• W1824130715 hasAuthorship W1824130715A5014328287 @default.
• W1824130715 hasAuthorship W1824130715A5015533161 @default.
• W1824130715 hasAuthorship W1824130715A5041915207 @default.
• W1824130715 hasAuthorship W1824130715A5044335396 @default.
• W1824130715 hasAuthorship W1824130715A5046201736 @default.
• W1824130715 hasAuthorship W1824130715A5049664359 @default.
• W1824130715 hasAuthorship W1824130715A5052051439 @default.
• W1824130715 hasAuthorship W1824130715A5057314490 @default.
• W1824130715 hasBestOaLocation W18241307151 @default.
• W1824130715 hasConcept C104317684 @default.
• W1824130715 hasConcept C143065580 @default.
• W1824130715 hasConcept C181199279 @default.
• W1824130715 hasConcept C197957613 @default.
• W1824130715 hasConcept C2775988993 @default.
• W1824130715 hasConcept C2776317432 @default.

• next