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- W1824231381 endingPage "444" @default.
- W1824231381 startingPage "431" @default.
- W1824231381 abstract "In skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation, and in the regulation of the mitochondrial acetyl-CoA/CoASH ratio. Interest in these vital metabolic roles of carnitine in skeletal muscle appears to have waned over the past 25 years. However, recent research has shed new light on the importance of carnitine as a regulator of muscle fuel selection. It has been established that muscle free carnitine availability may be limiting to fat oxidation during high intensity submaximal exercise. Furthermore, increasing muscle total carnitine content in resting healthy humans (via insulin-mediated stimulation of muscle carnitine transport) reduces muscle glycolysis, increases glycogen storage and is accompanied by an apparent increase in fat oxidation. By increasing muscle pyruvate dehydrogenase complex (PDC) activity and acetylcarnitine content at rest, it has also been established that PDC flux and acetyl group availability limits aerobic ATP re-synthesis at the onset of exercise (the acetyl group deficit). Thus, carnitine plays a vital role in the regulation of muscle fuel metabolism. The demonstration that its availability can be readily manipulated in humans, and impacts on physiological function, will result in renewed business and scientific interest in this compound." @default.
- W1824231381 created "2016-06-24" @default.
- W1824231381 creator A5015042508 @default.
- W1824231381 creator A5046267204 @default.
- W1824231381 creator A5085953050 @default.
- W1824231381 date "2007-05-23" @default.
- W1824231381 modified "2023-10-04" @default.
- W1824231381 title "New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle" @default.
- W1824231381 cites W118527734 @default.
- W1824231381 cites W1492563460 @default.
- W1824231381 cites W1514725289 @default.
- W1824231381 cites W1514745038 @default.
- W1824231381 cites W1531062343 @default.
- W1824231381 cites W1542788366 @default.
- W1824231381 cites W1569055531 @default.
- W1824231381 cites W1577348758 @default.
- W1824231381 cites W1592955275 @default.
- W1824231381 cites W1613234551 @default.
- W1824231381 cites W1673932087 @default.
- W1824231381 cites W1678070292 @default.
- W1824231381 cites W1748234316 @default.
- W1824231381 cites W1749780042 @default.
- W1824231381 cites W1783564712 @default.
- W1824231381 cites W1790392547 @default.
- W1824231381 cites W1790780945 @default.
- W1824231381 cites W1840670394 @default.
- W1824231381 cites W188562495 @default.
- W1824231381 cites W190244646 @default.
- W1824231381 cites W1955672048 @default.
- W1824231381 cites W1964457740 @default.
- W1824231381 cites W1971705681 @default.
- W1824231381 cites W1971973726 @default.
- W1824231381 cites W1980100048 @default.
- W1824231381 cites W1982532910 @default.
- W1824231381 cites W1986027034 @default.
- W1824231381 cites W1988632024 @default.
- W1824231381 cites W1992592537 @default.
- W1824231381 cites W1993137299 @default.
- W1824231381 cites W2000517120 @default.
- W1824231381 cites W200185773 @default.
- W1824231381 cites W2005883651 @default.
- W1824231381 cites W2008110031 @default.
- W1824231381 cites W2008155571 @default.
- W1824231381 cites W2012792816 @default.
- W1824231381 cites W2012898950 @default.
- W1824231381 cites W2013155381 @default.
- W1824231381 cites W2013979638 @default.
- W1824231381 cites W2017418536 @default.
- W1824231381 cites W2017731348 @default.
- W1824231381 cites W2029970717 @default.
- W1824231381 cites W2031846075 @default.
- W1824231381 cites W2034266949 @default.
- W1824231381 cites W2042771046 @default.
- W1824231381 cites W2043066420 @default.
- W1824231381 cites W2048629134 @default.
- W1824231381 cites W2057816478 @default.
- W1824231381 cites W2057850545 @default.
- W1824231381 cites W2062000453 @default.
- W1824231381 cites W2063214510 @default.
- W1824231381 cites W2063367773 @default.
- W1824231381 cites W2063977510 @default.
- W1824231381 cites W2065658266 @default.
- W1824231381 cites W2070825305 @default.
- W1824231381 cites W2070959110 @default.
- W1824231381 cites W2071022806 @default.
- W1824231381 cites W2079072785 @default.
- W1824231381 cites W2084837757 @default.
- W1824231381 cites W2087890598 @default.
- W1824231381 cites W2092623658 @default.
- W1824231381 cites W2094572802 @default.
- W1824231381 cites W2097080554 @default.
- W1824231381 cites W2097601607 @default.
- W1824231381 cites W2100803578 @default.
- W1824231381 cites W2101461546 @default.
- W1824231381 cites W2103213593 @default.
- W1824231381 cites W2107778633 @default.
- W1824231381 cites W2108577381 @default.
- W1824231381 cites W2109791231 @default.
- W1824231381 cites W2110476541 @default.
- W1824231381 cites W2111773310 @default.
- W1824231381 cites W2114858309 @default.
- W1824231381 cites W2115059371 @default.
- W1824231381 cites W2115379691 @default.
- W1824231381 cites W2123396581 @default.
- W1824231381 cites W2127179823 @default.
- W1824231381 cites W2128477744 @default.
- W1824231381 cites W2129233896 @default.
- W1824231381 cites W2134384840 @default.
- W1824231381 cites W2143035710 @default.
- W1824231381 cites W2143900574 @default.
- W1824231381 cites W2150112028 @default.
- W1824231381 cites W2152461518 @default.
- W1824231381 cites W2153270424 @default.
- W1824231381 cites W2161310946 @default.
- W1824231381 cites W2163771782 @default.
- W1824231381 cites W2164082439 @default.
- W1824231381 cites W2164747025 @default.
- W1824231381 cites W2169915927 @default.