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• W1824400675 startingPage "5087" @default.
• W1824400675 abstract "Expression of the arginase (CAR1) gene in Saccharomyces cerevisiae is induced by arginine or its analog homoarginine. Induction has been previously shown to require a negatively acting upstream repression sequence, which maintains expression of the gene at a low level in the absence of inducer. The objective of this work was to identify the cis-acting elements responsible for CAR1 transcriptional activation and response to inducer. We identified three upstream activation sequences (UASs) that support transcriptional activation in a heterologous expression vector. Two of these UAS elements function in the absence of inducer, whereas the third functions only when inducer is present. One of the inducer-independent UAS elements exhibits significant homology to the Sp1 factor-binding sites identified in simian virus 40 and various mammalian genes." @default.
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• W1824400675 date "1990-10-01" @default.
• W1824400675 modified "2023-09-27" @default.
• W1824400675 title "Multiple positive and negative cis-acting elements mediate induced arginase (CAR1) gene expression in Saccharomyces cerevisiae." @default.
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• W1824400675 doi "https://doi.org/10.1128/mcb.10.10.5087" @default.
• W1824400675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/361176" @default.
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