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- W182445619 abstract "The authors studied postnatal changes in ion and water transport, and glycoprotein secretion (GPS) in tracheal tissues (mounted in vitro) from sheep 0,2,4 and 8 weeks old (n=5 each group) and compared values to those from adult sheep. Cl/sup -/, Na/sup +/ and water fluxes were measured under open-circuit (OC) and short-circuit (SC) conditions. For GPS the authors added /sup 35/SO/sub 4/ and /sup 3/H-threonine to the serosa, and measured GP-bound-/sup 35/S and -/sup 3/H output on the mucosa. In newborns (0 weeks) there was net Cl/sup -/ secretion (mean +/-SD: 1.0+/-0.7, ..mu..Eq/cm/sup 2//h) but no net Na/sup +/ movement at SC: net Cl/sup -/ secretion remained under OC, coupled with net water secretion (12 +/- 21 ..mu..l/cm/sup 2//h). Net Cl/sup -/ secretion at SC did not change significantly with age, while net Na/sup +/ absorption developed by 2 weeks and approached adult values (1.6 +/- 0.5 ..mu..Eq/cm/sup 2//h) by 8 weeks (1.1 +/- 0.9 ..mu..Eq/cm/sup 2//h). There was no OC net flux of water except in newborn tissues. Basal GPS, especially of SO/sub 4/-GP, was greatly increased in newborns (p<0.05), but decreased to near adult values by 2 weeks. The /sup 35/S: /sup 3/H ratio gradually decreased from 4.2more » +/- 1.3 at 0 weeks to 2.0 +/- 0.7 at 8 weeks. These results show that in sheep, tracheal ion transport and GPS approach adult values by 4-8 weeks. Values at 0 weeks were similar to those reported for fetal sheep trachea (a Cl/sup -//liquid-secreting tissue), and confirm the clinical observation of mucus hypersecretion in the airways of newborns; this mucus may have abnormal biochemical properties.« less" @default.
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- W182445619 date "1986-03-05" @default.
- W182445619 modified "2023-09-24" @default.
- W182445619 title "Development of ion transport and glycoprotein secretion in sheep trachea" @default.
- W182445619 hasPublicationYear "1986" @default.
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