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- W1824457568 abstract "Abstract To check the reliability of the Ames MPS paper spot test, which is based on the Azure A dye, we sent a series of urine samples to three laboratories where the spot test is part of the metabolic screening for mucopolysaccharidoses. In these laboratories false-negative results ranged between 19% and 35% and false-positive results ranged between 12% and 29% of all samples submitted. In contrast, the quantitative dimethylmethylene blue test (Clin Chem 1989;35:1472-7) detected an increased glycosaminoglycan content in all urine samples from mucopolysaccharidosis patients and gave no false-positive results. In the latter procedure, glycosaminoglycan content is expressed per millimole of creatinine, and age-dependent reference values are used. We conclude that the Ames spot test and other spot tests are unreliable as a screening procedure for mucopolysaccharidoses and should not be used to screen for these diseases." @default.
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- W1824457568 date "1991-04-01" @default.
- W1824457568 modified "2023-09-25" @default.
- W1824457568 title "The spot test is not a reliable screening procedure for mucopolysaccharidoses" @default.
- W1824457568 doi "https://doi.org/10.1093/clinchem/37.4.572" @default.
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