Matches in SemOpenAlex for { <https://semopenalex.org/work/W1824539338> ?p ?o ?g. }
- W1824539338 endingPage "26" @default.
- W1824539338 startingPage "16" @default.
- W1824539338 abstract "Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our understanding of glioma genetics was revolutionized when mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) were identified in the vast majority of progressive gliomas and secondary glioblastomas (GBMs). IDH enzymes normally catalyze the decarboxylation of isocitrate to generate α-ketoglutarate (αKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of IDH2 confer a neomorphic enzyme activity that catalyzes reduction of αKG into the putative oncometabolite D-2-hydroxyglutate (D2HG). D2HG inhibits αKG-dependent dioxygenases and is thought to create a cellular state permissive to malignant transformation by altering cellular epigenetics and blocking normal differentiation processes. Herein, we discuss the relevant literature on mechanistic studies of IDH1/2 mutations in gliomas, and we review the potential impact of IDH1/2 mutations on molecular classification and glioma therapy." @default.
- W1824539338 created "2016-06-24" @default.
- W1824539338 creator A5003944261 @default.
- W1824539338 creator A5034933958 @default.
- W1824539338 creator A5088890711 @default.
- W1824539338 date "2015-07-16" @default.
- W1824539338 modified "2023-10-14" @default.
- W1824539338 title "Isocitrate dehydrogenase mutations in gliomas" @default.
- W1824539338 cites W135930319 @default.
- W1824539338 cites W1525523952 @default.
- W1824539338 cites W1921809757 @default.
- W1824539338 cites W1953089061 @default.
- W1824539338 cites W1964001245 @default.
- W1824539338 cites W1964150693 @default.
- W1824539338 cites W1966463163 @default.
- W1824539338 cites W1969013165 @default.
- W1824539338 cites W1969904124 @default.
- W1824539338 cites W1970074234 @default.
- W1824539338 cites W1971413372 @default.
- W1824539338 cites W1981487137 @default.
- W1824539338 cites W1982069260 @default.
- W1824539338 cites W1984513377 @default.
- W1824539338 cites W1986092833 @default.
- W1824539338 cites W1988756388 @default.
- W1824539338 cites W1988887928 @default.
- W1824539338 cites W1995675594 @default.
- W1824539338 cites W1996492681 @default.
- W1824539338 cites W2000846273 @default.
- W1824539338 cites W2001493754 @default.
- W1824539338 cites W2007673878 @default.
- W1824539338 cites W2011376261 @default.
- W1824539338 cites W2011570504 @default.
- W1824539338 cites W2012369631 @default.
- W1824539338 cites W2012588998 @default.
- W1824539338 cites W2012930481 @default.
- W1824539338 cites W2013020286 @default.
- W1824539338 cites W2015755329 @default.
- W1824539338 cites W2019584119 @default.
- W1824539338 cites W2022064821 @default.
- W1824539338 cites W2032077086 @default.
- W1824539338 cites W2039945243 @default.
- W1824539338 cites W2040827479 @default.
- W1824539338 cites W2043720679 @default.
- W1824539338 cites W2046796218 @default.
- W1824539338 cites W2047867594 @default.
- W1824539338 cites W2052229224 @default.
- W1824539338 cites W2055340778 @default.
- W1824539338 cites W2058417905 @default.
- W1824539338 cites W2061254489 @default.
- W1824539338 cites W2066237557 @default.
- W1824539338 cites W2067537818 @default.
- W1824539338 cites W2074200851 @default.
- W1824539338 cites W2074448607 @default.
- W1824539338 cites W2078972833 @default.
- W1824539338 cites W2079949890 @default.
- W1824539338 cites W2080418553 @default.
- W1824539338 cites W2080452140 @default.
- W1824539338 cites W2085293170 @default.
- W1824539338 cites W2088631065 @default.
- W1824539338 cites W2094395160 @default.
- W1824539338 cites W2094851085 @default.
- W1824539338 cites W2096681571 @default.
- W1824539338 cites W2096796171 @default.
- W1824539338 cites W2100795816 @default.
- W1824539338 cites W2100901335 @default.
- W1824539338 cites W2101986593 @default.
- W1824539338 cites W2103192145 @default.
- W1824539338 cites W2104669585 @default.
- W1824539338 cites W2105100844 @default.
- W1824539338 cites W2105348749 @default.
- W1824539338 cites W2105401493 @default.
- W1824539338 cites W2105528101 @default.
- W1824539338 cites W2107007091 @default.
- W1824539338 cites W2108648814 @default.
- W1824539338 cites W2109816625 @default.
- W1824539338 cites W2111163869 @default.
- W1824539338 cites W2112495947 @default.
- W1824539338 cites W2112567075 @default.
- W1824539338 cites W2116516144 @default.
- W1824539338 cites W2119118275 @default.
- W1824539338 cites W2120963683 @default.
- W1824539338 cites W2124951199 @default.
- W1824539338 cites W2126817554 @default.
- W1824539338 cites W2130511906 @default.
- W1824539338 cites W2131117209 @default.
- W1824539338 cites W2131860315 @default.
- W1824539338 cites W2132555177 @default.
- W1824539338 cites W2133865472 @default.
- W1824539338 cites W2137361994 @default.
- W1824539338 cites W2138320521 @default.
- W1824539338 cites W2142630775 @default.
- W1824539338 cites W2142898716 @default.
- W1824539338 cites W2143078369 @default.
- W1824539338 cites W2147013683 @default.
- W1824539338 cites W2149343603 @default.
- W1824539338 cites W2149409455 @default.
- W1824539338 cites W2152496375 @default.
- W1824539338 cites W2154193486 @default.