Matches in SemOpenAlex for { <https://semopenalex.org/work/W1824643118> ?p ?o ?g. }
- W1824643118 endingPage "594" @default.
- W1824643118 startingPage "585" @default.
- W1824643118 abstract "Surgical management of ovarian tumours largely depends on their histo-pathological diagnosis. Currently, screening for ovarian malignancy with tumour markers in conjunction with radiological investigations has a low specificity for discriminating benign from malignant tumours. Also, pre-operative biopsy of ovarian masses increases the risk of intra-peritoneal dissemination of malignancy. Intra-operative frozen section, although sufficiently accurate in differentiating tumours according to their histological type, increases operation times. This results in increased surgery-related risks to the patient and additional burden to resource allocation. We set out to determine whether attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy, combined with chemometric analysis can be applied to discriminate between normal, borderline and malignant ovarian tumours and classify ovarian carcinoma subtypes according to the unique spectral signatures of their molecular composition. Formalin-fixed, paraffin-embedded ovarian tissue blocks were de-waxed, mounted on Low-E slides and desiccated before being analysed using ATR-FTIR spectroscopy. Chemometric analysis in the form of principal component analysis (PCA), successive projection algorithm (SPA) and genetic algorithm (GA), followed by linear discriminant analysis (LDA) of the obtained spectra revealed clear segregation between benign versus borderline versus malignant tumours as well as segregation between different histological tumour subtypes, when these approaches are used in combination. ATR-FTIR spectroscopy coupled with chemometric analysis has the potential to provide a novel diagnostic approach in the accurate diagnosis of ovarian tumours assisting surgical decision making to avoid under-treatment or over-treatment, with minimal impact to the patient." @default.
- W1824643118 created "2016-06-24" @default.
- W1824643118 creator A5032803754 @default.
- W1824643118 creator A5045978990 @default.
- W1824643118 creator A5056764919 @default.
- W1824643118 creator A5066627984 @default.
- W1824643118 creator A5071835845 @default.
- W1824643118 date "2016-01-01" @default.
- W1824643118 modified "2023-10-12" @default.
- W1824643118 title "ATR-FTIR spectroscopy coupled with chemometric analysis discriminates normal, borderline and malignant ovarian tissue: classifying subtypes of human cancer" @default.
- W1824643118 cites W1587493794 @default.
- W1824643118 cites W1961147514 @default.
- W1824643118 cites W1972383287 @default.
- W1824643118 cites W1972800256 @default.
- W1824643118 cites W1979407206 @default.
- W1824643118 cites W1979501562 @default.
- W1824643118 cites W1982316544 @default.
- W1824643118 cites W1983899390 @default.
- W1824643118 cites W1984167228 @default.
- W1824643118 cites W2001877789 @default.
- W1824643118 cites W2004904875 @default.
- W1824643118 cites W2007220222 @default.
- W1824643118 cites W2011055829 @default.
- W1824643118 cites W2017422910 @default.
- W1824643118 cites W2017604452 @default.
- W1824643118 cites W2020582501 @default.
- W1824643118 cites W2024358661 @default.
- W1824643118 cites W2025187077 @default.
- W1824643118 cites W2028894560 @default.
- W1824643118 cites W2029308959 @default.
- W1824643118 cites W2037421127 @default.
- W1824643118 cites W2042628443 @default.
- W1824643118 cites W2045131659 @default.
- W1824643118 cites W2049531636 @default.
- W1824643118 cites W2053667508 @default.
- W1824643118 cites W2088369868 @default.
- W1824643118 cites W2088433811 @default.
- W1824643118 cites W2121741947 @default.
- W1824643118 cites W2126233390 @default.
- W1824643118 cites W2129555238 @default.
- W1824643118 cites W2143219457 @default.
- W1824643118 cites W2144004177 @default.
- W1824643118 cites W2149076865 @default.
- W1824643118 cites W2155191323 @default.
- W1824643118 doi "https://doi.org/10.1039/c5an00939a" @default.
- W1824643118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26090781" @default.
- W1824643118 hasPublicationYear "2016" @default.
- W1824643118 type Work @default.
- W1824643118 sameAs 1824643118 @default.
- W1824643118 citedByCount "87" @default.
- W1824643118 countsByYear W18246431182016 @default.
- W1824643118 countsByYear W18246431182017 @default.
- W1824643118 countsByYear W18246431182018 @default.
- W1824643118 countsByYear W18246431182019 @default.
- W1824643118 countsByYear W18246431182020 @default.
- W1824643118 countsByYear W18246431182021 @default.
- W1824643118 countsByYear W18246431182022 @default.
- W1824643118 countsByYear W18246431182023 @default.
- W1824643118 crossrefType "journal-article" @default.
- W1824643118 hasAuthorship W1824643118A5032803754 @default.
- W1824643118 hasAuthorship W1824643118A5045978990 @default.
- W1824643118 hasAuthorship W1824643118A5056764919 @default.
- W1824643118 hasAuthorship W1824643118A5066627984 @default.
- W1824643118 hasAuthorship W1824643118A5071835845 @default.
- W1824643118 hasBestOaLocation W18246431181 @default.
- W1824643118 hasConcept C121608353 @default.
- W1824643118 hasConcept C126322002 @default.
- W1824643118 hasConcept C142724271 @default.
- W1824643118 hasConcept C154945302 @default.
- W1824643118 hasConcept C27438332 @default.
- W1824643118 hasConcept C2775934546 @default.
- W1824643118 hasConcept C2779399171 @default.
- W1824643118 hasConcept C2780427987 @default.
- W1824643118 hasConcept C3019054536 @default.
- W1824643118 hasConcept C41008148 @default.
- W1824643118 hasConcept C69738355 @default.
- W1824643118 hasConcept C71924100 @default.
- W1824643118 hasConceptScore W1824643118C121608353 @default.
- W1824643118 hasConceptScore W1824643118C126322002 @default.
- W1824643118 hasConceptScore W1824643118C142724271 @default.
- W1824643118 hasConceptScore W1824643118C154945302 @default.
- W1824643118 hasConceptScore W1824643118C27438332 @default.
- W1824643118 hasConceptScore W1824643118C2775934546 @default.
- W1824643118 hasConceptScore W1824643118C2779399171 @default.
- W1824643118 hasConceptScore W1824643118C2780427987 @default.
- W1824643118 hasConceptScore W1824643118C3019054536 @default.
- W1824643118 hasConceptScore W1824643118C41008148 @default.
- W1824643118 hasConceptScore W1824643118C69738355 @default.
- W1824643118 hasConceptScore W1824643118C71924100 @default.
- W1824643118 hasIssue "2" @default.
- W1824643118 hasLocation W18246431181 @default.
- W1824643118 hasLocation W18246431182 @default.
- W1824643118 hasOpenAccess W1824643118 @default.
- W1824643118 hasPrimaryLocation W18246431181 @default.
- W1824643118 hasRelatedWork W2023013605 @default.
- W1824643118 hasRelatedWork W2040745635 @default.
- W1824643118 hasRelatedWork W2052589448 @default.
- W1824643118 hasRelatedWork W2173381672 @default.