FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1824808675> ?p ?o ?g. }

• W1824808675 endingPage "5211" @default.
• W1824808675 startingPage "5203" @default.
• W1824808675 abstract "Chondroitin sulfate proteoglycans (CSPGs) are implicated in the regulation of axonal growth. We previously reported that the neurite-promoting activity of laminin is inhibited by association with a Schwann cell-derived CSPG and that endoneurial laminin may be inhibited by this CSPG as well [Zuo J, Hernandez YJ, Muir D (1998) Chondroitin sulfate proteoglycan with neurite-inhibiting activity is upregulated after peripheral nerve injury. J Neurobiol 34:41–54]. Mechanisms regulating axonal growth were studied by using an in vitro bioassay in which regenerating embryonic dorsal root ganglionic neurons (DRGn) were grown on sections of normal adult nerve. DRGn achieved slow neuritic growth on sections of normal nerve, which was reduced significantly by treatment with metalloproteinase inhibitors. Similar results were obtained on a synthetic substratum composed of laminin and inhibitory CSPG. DRGn expressed the matrix metalloproteinase, MMP-2, which was transported to the growth cone. Recombinant MMP-2 inactivated the neurite-inhibiting CSPG without hindering the neurite-promoting potential of laminin. Similarly, neuritic growth by DRGn cultured on normal nerve sections was increased markedly by first treating the nerve sections with MMP-2. The proteolytic deinhibition by MMP-2 was equivalent to and nonadditive with that achieved by chondroitinase, suggesting that both enzymes inactivated inhibitory CSPG. Additionally, the increases in neuritic growth resulting from treating nerve sections with MMP-2 or chondroitinase were blocked by anti-laminin antibodies. From these results we conclude that MMP-2 provides a mechanism for the deinhibition of laminin in the endoneurial basal lamina and may play an important role in the regeneration of peripheral nerve." @default.
• W1824808675 created "2016-06-24" @default.
• W1824808675 creator A5009055069 @default.
• W1824808675 creator A5015997761 @default.
• W1824808675 creator A5028537926 @default.
• W1824808675 creator A5042141904 @default.
• W1824808675 creator A5091380477 @default.
• W1824808675 date "1998-07-15" @default.
• W1824808675 modified "2023-09-27" @default.
• W1824808675 title "Neuronal Matrix Metalloproteinase-2 Degrades and Inactivates a Neurite-Inhibiting Chondroitin Sulfate Proteoglycan" @default.
• W1824808675 cites W1488746545 @default.
• W1824808675 cites W1559486481 @default.
• W1824808675 cites W1668379041 @default.
• W1824808675 cites W1808298470 @default.
• W1824808675 cites W1821151201 @default.
• W1824808675 cites W1941261748 @default.
• W1824808675 cites W1968969091 @default.
• W1824808675 cites W1970369915 @default.
• W1824808675 cites W1971487203 @default.
• W1824808675 cites W1975824640 @default.
• W1824808675 cites W1978837916 @default.
• W1824808675 cites W1986551332 @default.
• W1824808675 cites W1988169283 @default.
• W1824808675 cites W1993526435 @default.
• W1824808675 cites W1997541998 @default.
• W1824808675 cites W1998225973 @default.
• W1824808675 cites W2000359435 @default.
• W1824808675 cites W2002471001 @default.
• W1824808675 cites W2004006730 @default.
• W1824808675 cites W2006436391 @default.
• W1824808675 cites W2010160822 @default.
• W1824808675 cites W2010859284 @default.
• W1824808675 cites W2013951424 @default.
• W1824808675 cites W2017123981 @default.
• W1824808675 cites W2019600132 @default.
• W1824808675 cites W2019730170 @default.
• W1824808675 cites W2019854885 @default.
• W1824808675 cites W2030429558 @default.
• W1824808675 cites W2031593973 @default.
• W1824808675 cites W2031955116 @default.
• W1824808675 cites W2034533454 @default.
• W1824808675 cites W2041223163 @default.
• W1824808675 cites W2043522613 @default.
• W1824808675 cites W2046161327 @default.
• W1824808675 cites W2062822941 @default.
• W1824808675 cites W2070469106 @default.
• W1824808675 cites W2074306477 @default.
• W1824808675 cites W2075439988 @default.
• W1824808675 cites W2075849083 @default.
• W1824808675 cites W2087350656 @default.
• W1824808675 cites W2092274103 @default.
• W1824808675 cites W2093229003 @default.
• W1824808675 cites W2094331775 @default.
• W1824808675 cites W2095498651 @default.
• W1824808675 cites W2113723285 @default.
• W1824808675 cites W2131266253 @default.
• W1824808675 cites W2144351874 @default.
• W1824808675 cites W2156011701 @default.
• W1824808675 cites W2156479268 @default.
• W1824808675 cites W2159444937 @default.
• W1824808675 cites W2165871774 @default.
• W1824808675 cites W2166703723 @default.
• W1824808675 cites W2188416531 @default.
• W1824808675 cites W81300945 @default.
• W1824808675 doi "https://doi.org/10.1523/jneurosci.18-14-05203.1998" @default.
• W1824808675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6793496" @default.
• W1824808675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9651203" @default.
• W1824808675 hasPublicationYear "1998" @default.
• W1824808675 type Work @default.
• W1824808675 sameAs 1824808675 @default.
• W1824808675 citedByCount "268" @default.
• W1824808675 countsByYear W18248086752012 @default.
• W1824808675 countsByYear W18248086752013 @default.
• W1824808675 countsByYear W18248086752014 @default.
• W1824808675 countsByYear W18248086752015 @default.
• W1824808675 countsByYear W18248086752016 @default.
• W1824808675 countsByYear W18248086752017 @default.
• W1824808675 countsByYear W18248086752018 @default.
• W1824808675 countsByYear W18248086752019 @default.
• W1824808675 countsByYear W18248086752020 @default.
• W1824808675 countsByYear W18248086752021 @default.
• W1824808675 countsByYear W18248086752022 @default.
• W1824808675 countsByYear W18248086752023 @default.
• W1824808675 crossrefType "journal-article" @default.
• W1824808675 hasAuthorship W1824808675A5009055069 @default.
• W1824808675 hasAuthorship W1824808675A5015997761 @default.
• W1824808675 hasAuthorship W1824808675A5028537926 @default.
• W1824808675 hasAuthorship W1824808675A5042141904 @default.
• W1824808675 hasAuthorship W1824808675A5091380477 @default.
• W1824808675 hasBestOaLocation W18248086751 @default.
• W1824808675 hasConcept C105702510 @default.
• W1824808675 hasConcept C109523444 @default.
• W1824808675 hasConcept C113246987 @default.
• W1824808675 hasConcept C129987498 @default.
• W1824808675 hasConcept C135903288 @default.
• W1824808675 hasConcept C153074725 @default.
• W1824808675 hasConcept C153911025 @default.
• W1824808675 hasConcept C185592680 @default.

• next