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• W1824863906 abstract "Background Survival from Wilms tumor (WT) in sub‐Saharan Africa remains dismal as a result of on‐therapy mortality and treatment abandonment. Review of patients diagnosed from 2008 to 2011 in our Kenyan Wilms Tumor Registry showed a loss to follow up (LTFU) rate approaching 50%. The purpose of this study was to trace those LTFU, estimate the survival rate, and identify risk factors for treatment abandonment. Procedure We administered a comprehensive survey to parents of patients with WT at the two largest referral hospitals in Kenya to identify barriers to care. We also telephoned families who had abandoned care to determine vital status and identify risk factors for treatment abandonment. Results Of 136 registered patients, 77 were confirmed dead (56.7%), 38 remained alive (27.9%), and the vital status of 21 patients remains unknown (15.4%). After contacting 33 of the patients who either abandoned curative treatment (n = 34) or did not attend off‐therapy visits (n = 20), the best estimate of 2‐year overall survival of patients with WT in Kenya approaches 36%. Sixty‐three percent of parents misunderstood treatment plans and 55% encountered financial barriers. When asked how to increase comfort with the child's treatment, 27% of parents volunteered improving inefficient services and 26% volunteered reducing drug‐unavailability. Conclusions Treatment abandonment remains a significant problem contributing to increased mortality from WT in developing countries. This multi‐center survey identified the barriers to treatment completion from the parental perspective to be lack of education about WT and treatment, financial constraints, need for quality improvement, and drug‐unavailability. Pediatr Blood Cancer 2015;62:252–256. © 2014 Wiley Periodicals, Inc." @default.
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• W1824863906 date "2014-11-08" @default.
• W1824863906 modified "2023-10-17" @default.
• W1824863906 title "Risk factors for abandonment of Wilms tumor therapy in Kenya" @default.
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• W1824863906 doi "https://doi.org/10.1002/pbc.25312" @default.
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