FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1825156905> ?p ?o ?g. }

• W1825156905 endingPage "910" @default.
• W1825156905 startingPage "873" @default.
• W1825156905 abstract "Abstract trans ‐2‐Phencylcyclopropylamine (2‐ PCPA ), a potent, clinically used antidepressant, affects monoamine neurotransmitter levels by inhibiting the main metabolizing enzymes, monoamine oxidases ( MAO s). However, the antidepressant action of this compound was not fully explained by its effects on MAOs due to its wide variety of biological effects. 2‐ PCPA also affects depression‐associated pathophysiological pathways, and linked with increased levels of trace amines in brain, upregulation of GABA B receptors (where GABA is gamma amino butyric acid), modulation of phospholipid metabolism, and interference with various cytochrome P450 ( CYP ) enzymes. Consequently, despite its adverse effects and limited clinical applicability, 2‐ PCPA has attracted interest as a structural scaffold for the development of mechanism‐based inhibitors of various enzymes, including lysine‐specific demethylase 1 ( LSD 1), which is a possible target for cancer chemotherapy. In the recent years, many reports have appeared in the literature based on 2‐ PCPA scaffold and their potential medicinal implications. This review mainly focuses on the medicinal chemistry aspects including drug design, structure–activity relationships ( SAR ), biological and biochemical properties, and mechanism of actions of 2‐ PCPA and its derivatives. Furthermore, we also highlight recent advance in this area and discuss their future applications for beneficial therapeutic effects." @default.
• W1825156905 created "2016-06-24" @default.
• W1825156905 creator A5028637869 @default.
• W1825156905 creator A5044997693 @default.
• W1825156905 creator A5081576616 @default.
• W1825156905 date "2012-08-14" @default.
• W1825156905 modified "2023-10-11" @default.
• W1825156905 title "An Overview of Phenylcyclopropylamine Derivatives: Biochemical and Biological Significance and Recent Developments" @default.
• W1825156905 cites W1504779009 @default.
• W1825156905 cites W1508638897 @default.
• W1825156905 cites W1521546861 @default.
• W1825156905 cites W1523826770 @default.
• W1825156905 cites W1533736100 @default.
• W1825156905 cites W164155355 @default.
• W1825156905 cites W1963675326 @default.
• W1825156905 cites W1965258805 @default.
• W1825156905 cites W1966138471 @default.
• W1825156905 cites W1970653703 @default.
• W1825156905 cites W1972206605 @default.
• W1825156905 cites W1978344987 @default.
• W1825156905 cites W1978901513 @default.
• W1825156905 cites W1979098362 @default.
• W1825156905 cites W1979368197 @default.
• W1825156905 cites W1983125013 @default.
• W1825156905 cites W1983401069 @default.
• W1825156905 cites W1983532163 @default.
• W1825156905 cites W1983798804 @default.
• W1825156905 cites W1983910785 @default.
• W1825156905 cites W1988427135 @default.
• W1825156905 cites W199081716 @default.
• W1825156905 cites W1991414578 @default.
• W1825156905 cites W1992968933 @default.
• W1825156905 cites W1994153124 @default.
• W1825156905 cites W1997296133 @default.
• W1825156905 cites W2003774880 @default.
• W1825156905 cites W2004116204 @default.
• W1825156905 cites W2005575697 @default.
• W1825156905 cites W2005867783 @default.
• W1825156905 cites W2006294648 @default.
• W1825156905 cites W2007239864 @default.
• W1825156905 cites W2008631520 @default.
• W1825156905 cites W2009028301 @default.
• W1825156905 cites W2010394633 @default.
• W1825156905 cites W2011627436 @default.
• W1825156905 cites W2013810007 @default.
• W1825156905 cites W2014021851 @default.
• W1825156905 cites W2015138269 @default.
• W1825156905 cites W2015829419 @default.
• W1825156905 cites W2015845927 @default.
• W1825156905 cites W2019079031 @default.
• W1825156905 cites W2019620912 @default.
• W1825156905 cites W2020414099 @default.
• W1825156905 cites W2021072983 @default.
• W1825156905 cites W2022501235 @default.
• W1825156905 cites W2025768633 @default.
• W1825156905 cites W2028169362 @default.
• W1825156905 cites W2029158948 @default.
• W1825156905 cites W2029220014 @default.
• W1825156905 cites W2029858538 @default.
• W1825156905 cites W2033498239 @default.
• W1825156905 cites W2034107221 @default.
• W1825156905 cites W2036438243 @default.
• W1825156905 cites W2037624165 @default.
• W1825156905 cites W2037817306 @default.
• W1825156905 cites W2038059318 @default.
• W1825156905 cites W2039209783 @default.
• W1825156905 cites W2040025688 @default.
• W1825156905 cites W2043979050 @default.
• W1825156905 cites W2046204255 @default.
• W1825156905 cites W2048792349 @default.
• W1825156905 cites W2050336915 @default.
• W1825156905 cites W2050583113 @default.
• W1825156905 cites W2050723217 @default.
• W1825156905 cites W2052806300 @default.
• W1825156905 cites W2053996826 @default.
• W1825156905 cites W2054253103 @default.
• W1825156905 cites W2054564943 @default.
• W1825156905 cites W2057437339 @default.
• W1825156905 cites W2064047613 @default.
• W1825156905 cites W2064239907 @default.
• W1825156905 cites W2064887977 @default.
• W1825156905 cites W2065940829 @default.
• W1825156905 cites W2067013768 @default.
• W1825156905 cites W2068089569 @default.
• W1825156905 cites W2071093592 @default.
• W1825156905 cites W2072016709 @default.
• W1825156905 cites W2072042198 @default.
• W1825156905 cites W2072376676 @default.
• W1825156905 cites W2072677280 @default.
• W1825156905 cites W2074466372 @default.
• W1825156905 cites W2076168862 @default.
• W1825156905 cites W2078837146 @default.
• W1825156905 cites W2079368952 @default.
• W1825156905 cites W2082086284 @default.
• W1825156905 cites W2084306351 @default.
• W1825156905 cites W2085050037 @default.
• W1825156905 cites W2085307991 @default.
• W1825156905 cites W2086477943 @default.

• next