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- W1825366906 abstract "A novel class of photoreceptors, the intrinsically photosensitive retinal ganglion cells (ipRGCs), express the photopigment melanopsin and drive non-image-forming responses to light such as circadian photoentrainment, the pupillary light reflex and suppression of nocturnal melatonin production in the pineal. Because dendrites from one subclass of these cells – the M1-type ipRGCs – make presumptive synaptic contacts at sites of dopamine release from dopaminergic amacrine cells, they are prime targets for modulation by dopamine, a neuromodulator implicated in retinal circadian rhythms and light adaptation. In patch-clamp recordings from ipRGCs in intact rat retinas, dopamine attenuated the melanopsin-based photocurrent. We confirmed that this was the result of direct action on ipRGCs by replicating the effect in dissociated ipRGCs that were isolated from influences of other retinal neurons. In these recordings, the D1-family dopamine receptor agonist SKF38393 attenuated the photocurrent, caused a modest depolarization, and reduced the input resistance of ipRGCs. The D2-family agonist quinpirole had no effect on the photocurrent. Single-cell reverse-transcriptase polymerase chain reaction revealed that the majority of ipRGCs tested expressed drd1a, the gene coding for the D1a dopamine receptor. This finding was supported by immunohistochemical localization of D1a receptor protein in melanopsin-expressing ganglion cells. Finally, the adenylate cyclase activator forskolin, applied in combination with the phosphodiesterase inhibitor IBMX (isobutylmethylxanthine), mimicked the effects of SKF38393 on the ipRGC photocurrent, membrane potential and input resistance, consistent with a D1-receptor signaling pathway. These data suggest that dopamine, acting via D1-family receptors, alters the responses of ipRGCs and thus of non-image-forming vision." @default.
- W1825366906 created "2016-06-24" @default.
- W1825366906 creator A5043873239 @default.
- W1825366906 creator A5083481324 @default.
- W1825366906 creator A5091600534 @default.
- W1825366906 date "2012-02-01" @default.
- W1825366906 modified "2023-09-30" @default.
- W1825366906 title "Dopaminergic modulation of ganglion-cell photoreceptors in rat" @default.
- W1825366906 cites W121680641 @default.
- W1825366906 cites W1479926654 @default.
- W1825366906 cites W1503265626 @default.
- W1825366906 cites W1511847553 @default.
- W1825366906 cites W1560106330 @default.
- W1825366906 cites W1610621213 @default.
- W1825366906 cites W1676323133 @default.
- W1825366906 cites W1854755157 @default.
- W1825366906 cites W1971524741 @default.
- W1825366906 cites W1976560631 @default.
- W1825366906 cites W1980693199 @default.
- W1825366906 cites W1982438983 @default.
- W1825366906 cites W1990556558 @default.
- W1825366906 cites W1990880789 @default.
- W1825366906 cites W1992420220 @default.
- W1825366906 cites W2002761019 @default.
- W1825366906 cites W2004658929 @default.
- W1825366906 cites W2009077913 @default.
- W1825366906 cites W2011770871 @default.
- W1825366906 cites W2020996084 @default.
- W1825366906 cites W2023583278 @default.
- W1825366906 cites W2026126169 @default.
- W1825366906 cites W2031328896 @default.
- W1825366906 cites W2035162194 @default.
- W1825366906 cites W2035853180 @default.
- W1825366906 cites W2038289966 @default.
- W1825366906 cites W2039180341 @default.
- W1825366906 cites W2042432891 @default.
- W1825366906 cites W2046810744 @default.
- W1825366906 cites W2049862882 @default.
- W1825366906 cites W2054269602 @default.
- W1825366906 cites W2056797323 @default.
- W1825366906 cites W2057601872 @default.
- W1825366906 cites W2057788315 @default.
- W1825366906 cites W2058703825 @default.
- W1825366906 cites W2061683639 @default.
- W1825366906 cites W2064477711 @default.
- W1825366906 cites W2065635189 @default.
- W1825366906 cites W2066393571 @default.
- W1825366906 cites W2067459443 @default.
- W1825366906 cites W2067575450 @default.
- W1825366906 cites W2068952392 @default.
- W1825366906 cites W2073148060 @default.
- W1825366906 cites W2081818729 @default.
- W1825366906 cites W2081957674 @default.
- W1825366906 cites W2082823588 @default.
- W1825366906 cites W2083131272 @default.
- W1825366906 cites W2086015992 @default.
- W1825366906 cites W2086880198 @default.
- W1825366906 cites W2087380344 @default.
- W1825366906 cites W2088428828 @default.
- W1825366906 cites W2090196720 @default.
- W1825366906 cites W2090950039 @default.
- W1825366906 cites W2096517177 @default.
- W1825366906 cites W2099429157 @default.
- W1825366906 cites W2110382306 @default.
- W1825366906 cites W2111867236 @default.
- W1825366906 cites W2112456436 @default.
- W1825366906 cites W2114175845 @default.
- W1825366906 cites W2118108368 @default.
- W1825366906 cites W2123413608 @default.
- W1825366906 cites W2129876877 @default.
- W1825366906 cites W2131885744 @default.
- W1825366906 cites W2139451673 @default.
- W1825366906 cites W2141029861 @default.
- W1825366906 cites W2145749351 @default.
- W1825366906 cites W2147949992 @default.
- W1825366906 cites W2151041079 @default.
- W1825366906 cites W2151054528 @default.
- W1825366906 cites W2159503893 @default.
- W1825366906 cites W2164060165 @default.
- W1825366906 cites W2170465790 @default.
- W1825366906 cites W2424300387 @default.
- W1825366906 cites W4213205049 @default.
- W1825366906 doi "https://doi.org/10.1111/j.1460-9568.2011.07975.x" @default.
- W1825366906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3339262" @default.
- W1825366906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22304466" @default.
- W1825366906 hasPublicationYear "2012" @default.
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