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- W182542008 abstract "Production of irritants by microbes on or near the skin's surface may lead to skin inflammation as well as offensive odors. A mannitol hydrogen peroxide (MHP) mixture was found to reduce the production of skin irritating compounds by facultative Gram-negative bacteria. This control method appears to influence metabolic regulation rather than impacting microbial viability, an aspect important to the overall maintenance of normal skin microflora. A mixture of hydrogen peroxide and mannitol was heated for 7 hr at 97 °C resulting in a white granular solid. A 450- fold decrease in specific ammonia production was observed when Proteus mirabilis was grown in the presence of urea and MHP as compared to cells in urea alone. Furthermore, it was observed that MHP produced an 8- and 2- fold decrease in release of cytokines IL-lα and IL-8, respectively, in a P. mirabilis challenged skin model. It is hypothesized that MHP provides a sustainable discharge of oxygen that shifts the metabolism of the bacterium. This bacterial control system can be applied to personal and health care products to control odors and reduce bacterial induced skin irritation, all without employing harmful antimicrobials." @default.
- W182542008 created "2016-06-24" @default.
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- W182542008 date "2007-09-07" @default.
- W182542008 modified "2023-09-26" @default.
- W182542008 title "Use of Mannitol Hydrogen Peroxide to Control Microbial Produced Skin Irritants" @default.
- W182542008 doi "https://doi.org/10.1021/bk-2007-0967.ch015" @default.
- W182542008 hasPublicationYear "2007" @default.
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