Matches in SemOpenAlex for { <https://semopenalex.org/work/W182542369> ?p ?o ?g. }
- W182542369 endingPage "1787" @default.
- W182542369 startingPage "1777" @default.
- W182542369 abstract "Publisher Summary Vitamin D was originally discovered for its critical role in calcium homeostasis. However, it is now known that vitamin D has pleiotropic actions, and one of the more active areas of recent vitamin D research has focused on understanding its role as a modulator of immune system function. The past few years have provided a wealth of data to support a fundamental role for vitamin D signaling in regulating innate immunity in humans and a firm molecular basis for the numerous studies linking vitamin D deficiency with increased rates of infectious diseases. It is also now known that stimulation of naive macrophages through toll-like receptors (TLRs) strongly enhances vitamin D signaling through induction of CYP27B1 and vitamin D receptor (VDR) expression, which leads to production of hormonal 1,25(OH)2D3, and that the magnitude of this production is strongly dependent on ambient 25(OH)D3 concentrations. 1,25(OH)2D3 thus produced signals via the VDR to induce expression of key components of innate immune responses such as AMPs and the pattern recognition receptor NOD2. There is likely more to uncover in this area. In addition, the recognition of the importance of vitamin D in controlling innate immune function should spur renewed interest in developing vitamin D analogs that may find roles, if not as front-line therapies for infectious disease, as components of combined therapies to treat emerging antibiotic-resistant disease." @default.
- W182542369 created "2016-06-24" @default.
- W182542369 creator A5041687568 @default.
- W182542369 date "2011-01-01" @default.
- W182542369 modified "2023-09-27" @default.
- W182542369 title "Vitamin D and Innate Immunity" @default.
- W182542369 cites W1552925034 @default.
- W182542369 cites W1877060350 @default.
- W182542369 cites W1881370365 @default.
- W182542369 cites W1896814139 @default.
- W182542369 cites W1927671826 @default.
- W182542369 cites W1948742032 @default.
- W182542369 cites W1963512990 @default.
- W182542369 cites W1966355489 @default.
- W182542369 cites W1968870913 @default.
- W182542369 cites W1972181361 @default.
- W182542369 cites W1975593226 @default.
- W182542369 cites W1976955837 @default.
- W182542369 cites W1977598211 @default.
- W182542369 cites W1981525140 @default.
- W182542369 cites W1982020401 @default.
- W182542369 cites W1983987058 @default.
- W182542369 cites W1985558958 @default.
- W182542369 cites W1987643735 @default.
- W182542369 cites W1988779510 @default.
- W182542369 cites W1995744610 @default.
- W182542369 cites W1995858580 @default.
- W182542369 cites W1997152791 @default.
- W182542369 cites W1998446559 @default.
- W182542369 cites W2001079134 @default.
- W182542369 cites W2002619825 @default.
- W182542369 cites W2003293061 @default.
- W182542369 cites W2005032514 @default.
- W182542369 cites W2005427598 @default.
- W182542369 cites W2005988779 @default.
- W182542369 cites W2018558365 @default.
- W182542369 cites W2020799333 @default.
- W182542369 cites W2021206718 @default.
- W182542369 cites W2023425836 @default.
- W182542369 cites W2023635033 @default.
- W182542369 cites W2024976212 @default.
- W182542369 cites W2025374951 @default.
- W182542369 cites W2026312341 @default.
- W182542369 cites W2027738329 @default.
- W182542369 cites W2030426398 @default.
- W182542369 cites W2030936432 @default.
- W182542369 cites W2031772919 @default.
- W182542369 cites W2034752409 @default.
- W182542369 cites W2042675697 @default.
- W182542369 cites W2044645610 @default.
- W182542369 cites W2046318425 @default.
- W182542369 cites W2050280907 @default.
- W182542369 cites W2051287129 @default.
- W182542369 cites W2052206067 @default.
- W182542369 cites W2052505493 @default.
- W182542369 cites W2066203385 @default.
- W182542369 cites W2068191543 @default.
- W182542369 cites W2068698172 @default.
- W182542369 cites W2072432297 @default.
- W182542369 cites W2077120409 @default.
- W182542369 cites W2078520607 @default.
- W182542369 cites W2082363650 @default.
- W182542369 cites W2084589482 @default.
- W182542369 cites W2084630938 @default.
- W182542369 cites W2084951281 @default.
- W182542369 cites W2085793178 @default.
- W182542369 cites W2087740330 @default.
- W182542369 cites W2087818905 @default.
- W182542369 cites W2090239878 @default.
- W182542369 cites W2093206323 @default.
- W182542369 cites W2094464340 @default.
- W182542369 cites W2095351093 @default.
- W182542369 cites W2099665543 @default.
- W182542369 cites W2102354280 @default.
- W182542369 cites W2103009883 @default.
- W182542369 cites W2106093671 @default.
- W182542369 cites W2106449126 @default.
- W182542369 cites W2106459551 @default.
- W182542369 cites W2106606013 @default.
- W182542369 cites W2108872477 @default.
- W182542369 cites W2110521677 @default.
- W182542369 cites W2112056917 @default.
- W182542369 cites W2112523199 @default.
- W182542369 cites W2112876417 @default.
- W182542369 cites W2113537333 @default.
- W182542369 cites W2113647415 @default.
- W182542369 cites W2113810254 @default.
- W182542369 cites W2115226150 @default.
- W182542369 cites W2115289014 @default.
- W182542369 cites W2116558722 @default.
- W182542369 cites W2118437105 @default.
- W182542369 cites W2119701569 @default.
- W182542369 cites W2120241921 @default.
- W182542369 cites W2120490282 @default.
- W182542369 cites W2122748935 @default.
- W182542369 cites W2124070987 @default.
- W182542369 cites W2124580054 @default.
- W182542369 cites W2125296327 @default.