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• W1825485220 abstract "Manganese superoxide dismutase (MnSOD) is considered a critical component of the antioxidant systems that protect against oxidative damage. We are interested in the role of oxidative stress in bladder detrusor smooth muscle (SM) in different disease states. In this study, we generated an inducible, SM-specific Sod2 −/− mouse model to investigate the effects of MnSOD depletion on the function of the bladder. We crossbred floxed Sod2 ( Sod2 lox/lox ) mice with mice containing heterozygous knock-in of a gene encoding a tamoxifen-activated Cre recombinase in the SM22α promoter locus [SM-CreER T2 (ki) Cre/+ ]. We obtained Sod2 lox/lox ,SM-CreER T2 (ki) Cre/+ mice and injected 8-wk-old males with 4-hydroxytamoxifen to induce Cre-mediated excision of the floxed Sod2 allele. Twelve weeks later, SM-specific deletion of Sod2 and depletion of MnSOD were confirmed by polymerase chain reaction, immunoblotting, and immunohistochemistry. SM-specific Sod2 −/− mice exhibited normal growth with no gross abnormalities. A significant increase in nitrotyrosine concentration was found in bladder SM tissue of SM-specific Sod2 −/− mice compared with both wild-type mice and Sod2 +/+ , SM-CreER T2 (ki) Cre/+ mice treated with 4-hydroxytamoxifen. Assessment of 24-h micturition in SM-specific Sod2 −/− mice revealed significantly higher voiding frequency compared with both wild-type and SM-specific Cre controls. Conscious cystometry revealed significantly shorter intercontraction intervals and lower functional bladder capacity in SM-specific Sod2 −/− mice compared with wild-type mice. This novel model can be used for exploring the mechanistic role of oxidative stress in organs rich in SM in different pathological conditions." @default.
• W1825485220 created "2016-06-24" @default.
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• W1825485220 date "2015-08-01" @default.
• W1825485220 modified "2023-10-10" @default.
• W1825485220 title "Bladder function in mice with inducible smooth muscle-specific deletion of the manganese superoxide dismutase gene" @default.
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• W1825485220 doi "https://doi.org/10.1152/ajpcell.00046.2015" @default.
• W1825485220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4525082" @default.
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