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- W1825517812 abstract "This chapter reviews the role of several hormones and their receptors in breast cancer tissues and examines mechanisms of control. Breast cancer is often hormone-responsive because growth or regression of tumors can often be modulated by appropriate endocrine manipulations. Estrogen and progesterone appear to be the major hormones involved in the regulation of breast tumor growth. The inference that each hormone acts independently through its receptor to control tumor growth is belied by the current studies showing that certain hormones are capable of regulating the receptor sites, metabolism, or nuclear translocation of others. This may begin to explain the complex hormonal interactions and the requirements of normal and neoplastic breast tissues. Considerable progress has, thus, been made in understanding the basis for success of various ablative therapies. Many of the studies on hormone-dependent breast carcinoma employ animal models, particularly carcinogen-induced rat mammary tumors, which regress after endocrine ablative surgery. The chapter discusses the relevance of these animal models to the clinical problem of human breast cancer. It illustrates the physiological principles of hormone action in breast cancer tissue so that an appreciation of the mechanism of endocrine-induced breast tumor regression will develop. Such an understanding should lead to a more rational approach for selecting or rejecting endocrine therapy for advanced breast cancer patients." @default.
- W1825517812 created "2016-06-24" @default.
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- W1825517812 date "1978-01-01" @default.
- W1825517812 modified "2023-09-25" @default.
- W1825517812 title "Steroid Receptors in Breast Tumors—Current Status" @default.
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