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- W1825688753 abstract "Background Coronary artery reimplantation is crucial step during the arterial switch (ASO) and Ross operation. Mortality and long-term outcome after the operation mainly depend on the patency and function of the reimplanted coronary arteries due to risk of stenosis, stretching, or occlusion. Cardiovascular magnetic resonance (CMR) imaging has emerged as a promising diagnostic tool for the evaluation of children heart. We utilized advanced CMR methods to perform a noninvasive assessment of myocardial blood flow, viability, function and diffuse fibrosis in patients after ASO and Ross operation to guide further therapy and for a better understanding of the microcirculation. Methods MRI first-pass perfusion imaging (0.03 mmol/kg GdDTPA; TR/TE/a=2.6/1.1/20°) was performed in 36 patients (age, 15.75±10.94 yrs; transposition of the great arteries post arterial switch operation n=25, post Ross operation for the treatment of aortic valve disease n= 11) and in 10 age matched healthy controls. Myocardial blood flow (ml/g/min) was calculated in 6 LV segments per slice (2-3 slices/pt). Quantitative blood flow at rest and stress (Adenosin 140 µg/kg/min) was derived from signal intensity curves by model independent deconvolution. Late enhancement studies (Gd 0.1 mmol/kg) using T1 weighted inversion recovery sequences were performed to detect myocardial scar. A Look-Locker technique (temporal resolution, 40 ms; slice thickness, 8 mm; repetition time, 3 R-R intervals) for measurements of T1 was used for detecting of LV diffuse fibrosis. Furthermore, cine MRI and 3 D coronary artery imaging were performed to assess ventricular function and coronary anatomy. Results" @default.
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- W1825688753 date "2015-02-03" @default.
- W1825688753 modified "2023-09-25" @default.
- W1825688753 title "Assessment of myocardial blood flow, viability and diffuse fibrosis in patients after arterial switch and ross operation with magnetic resonance imaging" @default.
- W1825688753 doi "https://doi.org/10.1186/1532-429x-17-s1-p103" @default.
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