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• W1825942364 startingPage "1103" @default.
• W1825942364 abstract "Abstract A novel transposon named ITmD37E was discovered in a wide range of mosquito species. Sequence analysis of multiple copies in three Aedes species showed similar terminal inverted repeats and common putative TA target site duplications. The ITmD37E transposases contain a conserved DD37E catalytic motif, which is unique among reported transposons of the IS630-Tc1-mariner superfamily. Sequence comparisons and phylogenetic analyses suggest that ITmD37E forms a novel family distinct from the widely distributed Tc1 (DD34E), mariner (DD34D), and pogo (DDxD) families in the IS630-Tc1-mariner superfamily. The inclusion in the phylogenetic analysis of recently reported transposons and transposons uncovered in our database survey provided revisions to previous classifications and identified two additional families, ITmD37D and ITmD39D, which contain DD37D and DD39D motifs, respectively. The above expansion and reorganization may open the doors to the discovery of related transposons in a broad range of organisms and help illustrate the evolution and structure-function relationships among these distinct transposases in the IS630-Tc1-mariner superfamily. The presence of intact open reading frames and highly similar copies in some of the newly characterized transposons suggests recent transposition. Studies of these novel families may add to the limited repertoire of transgenesis and mutagenesis tools for a wide range of organisms, including the medically important mosquitoes." @default.
• W1825942364 created "2016-06-24" @default.
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• W1825942364 date "2001-11-01" @default.
• W1825942364 modified "2023-09-30" @default.
• W1825942364 title "Expanding the Diversity of the <i>IS630-Tc1-mariner</i> Superfamily: Discovery of a Unique DD37E Transposon and Reclassification of the DD37D and DD39D Transposons" @default.
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• W1825942364 doi "https://doi.org/10.1093/genetics/159.3.1103" @default.
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