Matches in SemOpenAlex for { <https://semopenalex.org/work/W1826689095> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1826689095 endingPage "175" @default.
- W1826689095 startingPage "172" @default.
- W1826689095 abstract "Previously, we demonstrated that administering vitamin A supplements to children resulted in a significant increase in the immunoglobulin G (IgG) response generated against a vaccine dose of tetanus toxoid (TT) (R. D. Semba et al., J. Nutr. 122:101-107, 1991). However, from these analyses we could not determine whether there was an increase in levels of IgG of the subclass presumed to be important for protection against challenge by the toxin or whether there was simply a general increase in the levels of all the IgG subclasses expressing anti-TT activity. The goal of this study was to determine the profile of the anti-TT IgG subclasses in children receiving vitamin A supplementation or a placebo in order to assess the potential utility of the enhanced anti-TT response. In a randomized, double-masked, placebo-controlled clinical trial, the levels of the different anti-TT IgG subclasses were measured in 139 Indonesian preschool children (3 to 6 years of age) 2 weeks before and 3 weeks after immunization. Baseline anti-TT levels and immunization histories were used to separate those children who were responding to TT for the first time from those who responded in a secondary fashion because of previous exposure to TT. Children who were given vitamin A prior to immunization had significant increases in IgG1 levels regardless of whether they were undergoing primary or memory reactions. In the group of individuals who underwent a secondary response to TT, vitamin A supplementation was also associated with a modest but significant change in the levels of anti-TT IgG3. There were only minor changes in the levels of anti-TT IgG2 and IgG4. Since IgG1 is the subclass associated with a protective response to TT immunization, these results suggest that vitamin A supplementation may be a safe and effective intervention to enhance the relevant humoral response to TT and other vaccine antigens." @default.
- W1826689095 created "2016-06-24" @default.
- W1826689095 creator A5023495081 @default.
- W1826689095 creator A5029506023 @default.
- W1826689095 creator A5065234111 @default.
- W1826689095 creator A5067088770 @default.
- W1826689095 creator A5071249730 @default.
- W1826689095 creator A5071551351 @default.
- W1826689095 date "1994-03-01" @default.
- W1826689095 modified "2023-09-24" @default.
- W1826689095 title "Effect of vitamin A supplementation on immunoglobulin G subclass responses to tetanus toxoid in children" @default.
- W1826689095 cites W1493512966 @default.
- W1826689095 cites W1628283138 @default.
- W1826689095 cites W1749317676 @default.
- W1826689095 cites W1921089305 @default.
- W1826689095 cites W1970676827 @default.
- W1826689095 cites W1971344654 @default.
- W1826689095 cites W2007336329 @default.
- W1826689095 cites W2030907932 @default.
- W1826689095 cites W2043467656 @default.
- W1826689095 cites W2070964909 @default.
- W1826689095 cites W2074050842 @default.
- W1826689095 cites W2089169038 @default.
- W1826689095 cites W2092689342 @default.
- W1826689095 cites W2140600592 @default.
- W1826689095 cites W2165870871 @default.
- W1826689095 cites W2335402024 @default.
- W1826689095 doi "https://doi.org/10.1128/cdli.1.2.172-175.1994" @default.
- W1826689095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/368222" @default.
- W1826689095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7496940" @default.
- W1826689095 hasPublicationYear "1994" @default.
- W1826689095 type Work @default.
- W1826689095 sameAs 1826689095 @default.
- W1826689095 citedByCount "27" @default.
- W1826689095 countsByYear W18266890952012 @default.
- W1826689095 countsByYear W18266890952014 @default.
- W1826689095 countsByYear W18266890952015 @default.
- W1826689095 countsByYear W18266890952017 @default.
- W1826689095 countsByYear W18266890952018 @default.
- W1826689095 countsByYear W18266890952019 @default.
- W1826689095 countsByYear W18266890952022 @default.
- W1826689095 crossrefType "journal-article" @default.
- W1826689095 hasAuthorship W1826689095A5023495081 @default.
- W1826689095 hasAuthorship W1826689095A5029506023 @default.
- W1826689095 hasAuthorship W1826689095A5065234111 @default.
- W1826689095 hasAuthorship W1826689095A5067088770 @default.
- W1826689095 hasAuthorship W1826689095A5071249730 @default.
- W1826689095 hasAuthorship W1826689095A5071551351 @default.
- W1826689095 hasBestOaLocation W18266890952 @default.
- W1826689095 hasConcept C126322002 @default.
- W1826689095 hasConcept C142724271 @default.
- W1826689095 hasConcept C159654299 @default.
- W1826689095 hasConcept C203014093 @default.
- W1826689095 hasConcept C204787440 @default.
- W1826689095 hasConcept C22070199 @default.
- W1826689095 hasConcept C27081682 @default.
- W1826689095 hasConcept C2776194381 @default.
- W1826689095 hasConcept C2776940978 @default.
- W1826689095 hasConcept C2777351567 @default.
- W1826689095 hasConcept C2779841045 @default.
- W1826689095 hasConcept C2780801004 @default.
- W1826689095 hasConcept C71924100 @default.
- W1826689095 hasConcept C90924648 @default.
- W1826689095 hasConceptScore W1826689095C126322002 @default.
- W1826689095 hasConceptScore W1826689095C142724271 @default.
- W1826689095 hasConceptScore W1826689095C159654299 @default.
- W1826689095 hasConceptScore W1826689095C203014093 @default.
- W1826689095 hasConceptScore W1826689095C204787440 @default.
- W1826689095 hasConceptScore W1826689095C22070199 @default.
- W1826689095 hasConceptScore W1826689095C27081682 @default.
- W1826689095 hasConceptScore W1826689095C2776194381 @default.
- W1826689095 hasConceptScore W1826689095C2776940978 @default.
- W1826689095 hasConceptScore W1826689095C2777351567 @default.
- W1826689095 hasConceptScore W1826689095C2779841045 @default.
- W1826689095 hasConceptScore W1826689095C2780801004 @default.
- W1826689095 hasConceptScore W1826689095C71924100 @default.
- W1826689095 hasConceptScore W1826689095C90924648 @default.
- W1826689095 hasIssue "2" @default.
- W1826689095 hasLocation W18266890951 @default.
- W1826689095 hasLocation W18266890952 @default.
- W1826689095 hasOpenAccess W1826689095 @default.
- W1826689095 hasPrimaryLocation W18266890951 @default.
- W1826689095 hasRelatedWork W1628283138 @default.
- W1826689095 hasRelatedWork W168309117 @default.
- W1826689095 hasRelatedWork W169557441 @default.
- W1826689095 hasRelatedWork W2020791381 @default.
- W1826689095 hasRelatedWork W2054521998 @default.
- W1826689095 hasRelatedWork W2463559906 @default.
- W1826689095 hasRelatedWork W2471706182 @default.
- W1826689095 hasRelatedWork W29877242 @default.
- W1826689095 hasRelatedWork W41506990 @default.
- W1826689095 hasRelatedWork W4290195067 @default.
- W1826689095 hasVolume "1" @default.
- W1826689095 isParatext "false" @default.
- W1826689095 isRetracted "false" @default.
- W1826689095 magId "1826689095" @default.
- W1826689095 workType "article" @default.